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Telik Reports Positive Data Demonstrating Synergy in Combination,and Highly Statistically Significant Effect of Telcyta as,Maintenance Therapy in First-Line Non-Small Cell Lung Cancer

PALO ALTO, Calif., April 17, 2007 /PRNewswire-FirstCall/ -- Telik, Inc. announced the presentation today of results from a Phase 2 clinical trial of the triplet combination of TELCYTA(R) (canfosfamide HCl, TLK286), carboplatin and paclitaxel in the first-line treatment of advanced non-small cell lung cancer. The results include highly statistically and clinically significant improvement in both progression-free survival and overall survival in responding patients who received TELCYTA maintenance therapy as compared with those who did not receive TELCYTA maintenance therapy. The data were presented at the 98th annual meeting of the American Association for Cancer Research (AACR) in Los Angeles.

The multicenter dose-ranging study enrolled 129 patients with Stage IIIB or IV non-small cell lung cancer. Patients received standard doses of carboplatin and paclitaxel and one of four doses of TELCYTA (400, 500, 750 or 1,000 mg/m2) for a planned course of four to six cycles. Patients with objective responses or stable disease following completion of combination therapy could elect to receive every three week maintenance cycles of TELCYTA as monotherapy until disease progression. Outcomes to be evaluated included safety, objective response and disease stabilization rates, progression-free survival and overall survival in the intent-to-treat population, and safety, progression-free survival and overall survival in patients receiving TELCYTA maintenance therapy.

In the intent-to-treat population (n = 129), the overall objective response rate was 34% (95% CI 26%, 43%), including one complete response. Fifty-six patients, or 43%, had disease stabilization, for an overall disease stabilization rate of 77% (95% CI 69%, 84%). Median progression-free survival was 4.9 months, and the overall median survival was 9.6 months.

One hundred patients (77% of enrolled patients) had objective responses or stable disea
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