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Targanta Study Shows Oritavancin Treatment Effective in a Mouse,Model of Anthrax

deaths and 125,000 hospitalizations.

About Oritavancin

Oritavancin, Targanta's lead product candidate, is a semi-synthetic lipoglycopeptide antibiotic with rapid in vitro bactericidal activity against a broad spectrum of serious gram-positive pathogens, including multi-resistant strains. Oritavancin's multiple targets and mechanisms of action work against the development of resistant strains, which is important when treating serious gram-positive infections. To date, over 1500 individuals have received oritavancin in clinical trials, including two large multi-national Phase 3 studies in complicated skin and skin structure infections (cSSSI) performed by former developers Eli Lilly and Company and InterMune, Inc. Targanta expects to file a New Drug Application (NDA) for oritavancin for the treatment of cSSSI with the U.S. Food and Drug Administration in the first quarter of 2008.

About Targanta Therapeutics Corporation

Targanta Therapeutics Corporation is a privately held biopharmaceutical company developing and commercializing innovative antibiotics to treat serious infections (either treated or acquired) in the hospital and other institutional settings. Its pipeline includes a number of antibacterial agents in various stages of development. The company has operations in Cambridge, MA, Indianapolis, IN, Montreal, Quebec, and Toronto, Ontario, Canada. For further information about Targanta, visit the company website, http://www.targanta.com.

About U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)

USAMRIID, located at Fort Detrick, Maryland, is the lead medical research laboratory for the U.S. Biological Defense Research Program, and plays a key role in national defense and in infectious disease research. The Institute's mission is to conduct basic and applied research on biological threats resulting in medical solutions (such as vaccines, drugs and d
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