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Targanta Reports Improved Ability of Oritavancin to Stop Bacteria,Growth In Vitro Compared With Other Glycopeptide Antibiotics

lysorbate 80 on susceptibility of gram-positive bacteria to oritavancin (ECCMID/ICC07-P 827) Following initial observations that P80 reduced ORI MICs for S. aureus and E. faecalis but not for S. pneumoniae, this study examined the effect of P80 on ORI MICs for 301 clinical strains of bacteria from these three genera, in comparison with VAN and TEI. Researchers observed significant reductions in ORI MICs for enterococci and staphylococci with P80 (16- to 32-fold) while P80 had little to no effect on MICs for TEI and VAN. ORI MICs were unchanged with and without P80 for streptococci, which may be related to the inclusion of LHB in the culture medium. -- Efficacy of oritavancin in a mouse model of Streptococcus pneumoniae pneumonia (ECCMID/ICC07-P 1781) Streptococcus pneumoniae is one of the leading causes of community- acquired bacterial infections and can cause a number of infections including pneumonia, acute sinusitis, otitis media, bacteremia and meningitis(2). S. pneumoniae is a leading cause of morbidity and mortality in the United States, resulting each year in an estimated 500,000 cases of pneumonia. S. pneumoniae bacteria have been uniformly susceptible to penicillin in the past; however, as multi-drug resistant strains become more prevalent, first-line therapies such as penicillin are not always effective, and advanced agents are being explored to prevent complications or mortality. In Vivo Researchers tested the in vivo activity of ORI against penicillin- sensitive S. pneumoniae (PSSP) pneumonia in a mouse model, compared with daptomycin (DAP) and ceftriaxone (CTX). During the study, immunocompetent mice were exposed intranasally to one million colony-forming units (CFU) of PSSP. Doses of ORI (32 mg/kg
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