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Targanta Reports Improved Ability of Oritavancin to Stop Bacteria,Growth In Vitro Compared With Other Glycopeptide Antibiotics

ations for susceptibility testing (ECCMID/ICC07-P 1112) Researchers investigated whether polysorbate 80 (P80), a commonly used wetting agent, affects oritavancin (ORI) susceptibility test results. Testing the following both with and without P80, ORI and ciprofloxacin (CIP) were dissolved in water, diluted in cation-adjusted Mueller Hinton Broth (CAMHB) or CAMHB with two percent lysed horse blood (LHB), and dispensed into a microtiter plate for testing. Tests were conducted with Staphylococcus aureus (S. aureus), Enterococcus faecalis (E. faecalis) and Streptococcus pneumoniae (S. pneumoniae). S. aureus bacteria appear most commonly on the skin and nose, E. faecalis in the intestines, and S. pneumoniae in the nasal cavity, and all may lead to deadly infections.(1) Researchers found that without P80, ORI was rapidly lost from the solution, but inclusion of P80 or LHB promoted recovery of 80 to 100 percent of the agent for up to 24 hours. ORI minimal inhibitory concentrations (MICs) for S. aureus and E. faecalis were 16- to 32- fold lower in the presence of P80, compared with no MIC impact on vancomycin (VAN), teicoplanin (TEI) or CIP. ORI MICs for S. pneumoniae were identical with and without P80, likely as a result of LHB present in the microbiological culture medium for the pneumococcus. In addition, plates with low-binding surfaces demonstrated 4- to 8-fold reductions in ORI MICs without P80. These findings indicate that the addition of P80 to susceptibility tests minimizes ORI binding to plastic surfaces, which maintains ORI available in solution to stop growth of bacteria. Investigators also concluded that current literature on ORI MICs, without P80, may significantly underestimate its in vitro potency. -- Influence of po
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