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Targanta Reports Improved Ability of Oritavancin to Stop Bacteria,Growth In Vitro Compared With Other Glycopeptide Antibiotics

Three Oritavancin Studies Presented at ECCMID/ICC

MUNICH, Germany, April 03, 2007 /PRNewswire/ -- Targanta Therapeutics today announced results from two studies showing the improved potency of oritavancin to stop bacterial growth in vitro when tested with a common wetting agent (polysorbate 80) and one study demonstrating the activity of oritavancin against S. pneumoniae in a mouse model of pneumonia. Oritavancin, a novel lipoglycopeptide antibiotic, is Targanta's lead product currently in post- Phase 3 clinical development. These findings were presented at the 17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) and 25th International Congress of Chemotherapy (ICC) in Munich, Germany from March 31 - April 3, 2007.

"We are encouraged by the research demonstrating the improved activity of oritavancin when compared with other glycopeptide antibiotics. By combining oritavancin with a common wetting agent, it is evident that the ability of the treatment to inhibit bacteria growth, demonstrated through previous research, may be underestimated based on these recent studies," said Thomas Parr, Ph.D., Chief Scientific Officer, Targanta Therapeutics. "These data further support oritavancin as a potential treatment for serious bacterial infections, and Targanta will continue to explore this potential through ongoing clinical research."

    The following research was presented at the ECCMID/ICC meeting:

      --  Effect of polysorbate 80 on oritavancin binding to plastic surfaces

          -- implications for susceptibility testing (ECCMID/ICC07-P 1112)

      --  Influence of polysorbate 80 on susceptibility of gram-positive

          bacteria to oritavancin (ECCMID/ICC07-P 827)

      --  Efficacy of oritavancin in a mouse model of Streptococcus pneumoniae

          pneumonia (ECCMID/ICC07-P 1781)


    Study Methods and Results:

    --  Effect of polysorbate 80 on oritavancin binding to plastic surfaces --

        implic
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