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Synta Presents Results for STA-4783 in Metastatic Melanoma Showing,Improvement in Overall Survival

ssarily be predictive of results in larger, later-stage clinical trials and the other risk and uncertainties described under "Risk Factors" in our Form 10-K for the year ended December 31, 2006 as filed with the Securities and Exchange Commission. Synta undertakes no obligation to publicly update forward-looking statements, whether because of new information, future events or otherwise, except as required by law.

References

1. Tarhini and Agarwala, Dermatologic Therapy 2006, 19:19-25

2. Recently published randomized, controlled studies with DTIC as control:

-- Avril MF, et al: Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. J Clin Oncol 2004; 22(6):1118-1125;

-- Middleton MR, et al: Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol 2000; 18(1):158-166;

-- Chapman PB, et al: Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 1999; 17(9):2745-2751

-- Bedikian AY, et al: Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group. J Clin Oncol 2006; 24(29):4738-4745.

3. Manola et al, J Clinical Oncology 2000; 18(22):3782.

Contact

Synta Pharmaceuticals Corp.
Rob Kloppenburg, 781-541-7125
or
MacDougall Biomedical Communications
Doug MacDougall, 508-647-0209


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