Navigation Links
Synta Presents Results for STA-4783 in Metastatic Melanoma Showing,Improvement in Overall Survival

rolled trials for DTIC were 5.6, 6.4, 6.3, and 7.8 months respectively (2). A meta-analysis of over 1,300 patients with metastatic melanoma who received a variety of treatments showed a median overall survival time of 6.4 months (3). Other randomized trials have consistently shown a median survival time between six and nine months regardless of treatment (1).

STA-4783 was generally well-tolerated in this study; side effects were predictable and were generally comparable to treatment with paclitaxel alone. Neutropenia occurred more commonly in the STA-4783 plus paclitaxel group compared to the paclitaxel alone group, but this was manageable and reversible. Although paresthesias occurred more commonly in the STA-4783 plus paclitaxel group, the incidence of severe events of this type was low and comparable between groups. The most common adverse events in the STA-4783 plus paclitaxel group included fatigue, alopecia, constipation, nausea, hypoaesthesia, arthralgia, insomnia, diarrhea, and anemia.

About the Phase 2b Trial

The blinded, randomized Phase 2b clinical trial was conducted in 21 centers in the United States and compared patients treated with STA-4783 plus paclitaxel (N=53) vs. patients treated with paclitaxel alone (N=28). In the Phase 2b trial, patients who received STA-4783 plus paclitaxel showed a doubling of median progression free survival (PFS), the primary endpoint of the study, compared to those patients who received paclitaxel alone (3.68 months vs. 1.84 months, p=0.035). In addition, the PFS at six months, considered a useful predictor of overall survival, more than doubled (35% vs. 15%), and the response rate more than tripled (15% vs. 4%).

About STA-4783

STA-4783 is a novel, injectable, small molecule investigational drug candidate that induces a potent oxidative stress response in cancer cells, driving programmed cell death and enhancing the activity of anti-cancer agents that act through the mitochondrial apopto
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Synta Pharmaceuticals to Host Conference Call Today
2. Synta Oncology Candidate STA-4783 Clinical Trial Results to Be Presented at the ASCO Annual Meeting
3. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
4. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
5. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
6. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
7. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
8. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
9. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
10. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
11. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
Post Your Comments:
(Date:1/23/2015)... Inc. (NASDAQ: NWBO )("NW Bio"), a U.S. biotechnology ... solid tumor cancers, announced today that CEO Linda Powers ... Immunotherapy Forum in Washington D.C. ... January 26 at 10:30 a.m. EST at the Grand Hyatt ...
(Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Immune Therapeutics, ... Global Biotechnology, Inc. for the compounding, packaging and distributing of ... in the United States . ... capable of compounding naltrexone tablets in various strengths for individual ...
(Date:1/23/2015)... 2015  HyGreen, Inc., a leader in hand hygiene monitoring, ... Medical, a subsidiary of Ascendis Health Limited, in ... year, hundreds of millions of patients around the world ... transmitted from patient to patient via the unwashed hands ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... Feb. 1 Obese teenagers who,succeeded in losing weight ... their bone mineral content increase over that,period, say researchers ... because adolescence is a critical period for bone,health in ... of the journal Obesity studied 62,adolescents between the ages ...
... as part of innovative,Therapeutics Development Initiative, NEW YORK, ... do whatever it takes to speed delivery of transformative,treatments ... Fox,Foundation for Parkinson,s Research has awarded up to $3 ... push potential new PD treatments,closer to the clinic. The ...
Cached Medicine Technology:Bone Mineral Content Continues to Increase in Obese Adolescents During Weight Loss 2Bone Mineral Content Continues to Increase in Obese Adolescents During Weight Loss 3Michael J. Fox Foundation Awards Up to $3 Million to Industry Teams to Jumpstart Promising PD Drug Development 2Michael J. Fox Foundation Awards Up to $3 Million to Industry Teams to Jumpstart Promising PD Drug Development 3
(Date:1/22/2015)... The City of West Hollywood hosted a news conference ... 42nd anniversary of the Supreme Court decision Roe v. Wade, which ... since the Roe vs. Wade decision and the fight to protect ... said City of West Hollywood Councilmember Abbe Land. “We need to ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Gabe’s Chemo Duck Program ... App, the first app ever created for kids with cancer. The ... phones and devices, is filled with enjoyable games to help children ... treatments. The free app helps to keep kids entertained, educated and ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently delivers ... to have it lead the wedding dress industry into the ... dresses for the global market. , “The CEO of VogueQueen ... focuses on continuing the goal of operational excellence and giving ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... 2015 AngelWeddingDress, the premier women’s dress ... wedding dresses. View website of AngelWeddingDress.com to ... maternity wedding dresses online for a bridal party. AngelWeddingDress ... quality for them. Its maternity wedding dresses are specially ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... used for prevention of pregnancy for decades and more recently ... that wearing a condom during intercourse may not give good ... and syphilis. ,There has been a rise recently in ... the news may come as a surprise to many. Current ...
... risk of having a pre-term baby may perhaps will like ... that pomegranate juice can prevent brain injury the fetus may ... in case of a pre-term delivery., ,Pomegranate juice contains ... property of neuroprotection and anti-aging effects. ,Researchers from ...
... People may be reacting to varying degrees of energy loss ... // genetic predisposition. How our bodies react to exercise programs ... to exercising like the level of blood glucose in the ... works of scientists from Washington University School of Medicine, exercise ...
... Cancer Society researchers conducted in interesting national survey that ... look at the prevailing myths about cancer in the minds ... 957 adults with no history of cancer to assess their ... identify any associated misconceptions. Participants were asked if five misconceptions ...
... in temperate countries or colder regions of the world would ... Vitamin D in the winter months when the sunlight exposure ... formation of the active component of Vitamin D in the ... bones for later years. The researchers concluded in a study ...
... low birth weight may be at heightened risk// of cardiovascular ... as for the fathers. ,In a research done by ... that leads to low birth weight stems may lead to ... genetic condition coming from the parents. Hence parents of the ...
Cached Medicine News:Health News:Condoms May not be safe Enough 2Health News:Vitamin D Supplement in Teenage Girls essential in Winter months 2
...
...
The Lineage acetabular system with metal liners uses sophisticated manufacturing methods and materials to minimize wear debris generation....
Hemisphere modular Cup....
Medicine Products: