Navigation Links
Synta Presents Results for STA-4783 in Metastatic Melanoma Showing,Improvement in Overall Survival

rolled trials for DTIC were 5.6, 6.4, 6.3, and 7.8 months respectively (2). A meta-analysis of over 1,300 patients with metastatic melanoma who received a variety of treatments showed a median overall survival time of 6.4 months (3). Other randomized trials have consistently shown a median survival time between six and nine months regardless of treatment (1).

STA-4783 was generally well-tolerated in this study; side effects were predictable and were generally comparable to treatment with paclitaxel alone. Neutropenia occurred more commonly in the STA-4783 plus paclitaxel group compared to the paclitaxel alone group, but this was manageable and reversible. Although paresthesias occurred more commonly in the STA-4783 plus paclitaxel group, the incidence of severe events of this type was low and comparable between groups. The most common adverse events in the STA-4783 plus paclitaxel group included fatigue, alopecia, constipation, nausea, hypoaesthesia, arthralgia, insomnia, diarrhea, and anemia.

About the Phase 2b Trial

The blinded, randomized Phase 2b clinical trial was conducted in 21 centers in the United States and compared patients treated with STA-4783 plus paclitaxel (N=53) vs. patients treated with paclitaxel alone (N=28). In the Phase 2b trial, patients who received STA-4783 plus paclitaxel showed a doubling of median progression free survival (PFS), the primary endpoint of the study, compared to those patients who received paclitaxel alone (3.68 months vs. 1.84 months, p=0.035). In addition, the PFS at six months, considered a useful predictor of overall survival, more than doubled (35% vs. 15%), and the response rate more than tripled (15% vs. 4%).

About STA-4783

STA-4783 is a novel, injectable, small molecule investigational drug candidate that induces a potent oxidative stress response in cancer cells, driving programmed cell death and enhancing the activity of anti-cancer agents that act through the mitochondrial apopto
'"/>




Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Synta Pharmaceuticals to Host Conference Call Today
2. Synta Oncology Candidate STA-4783 Clinical Trial Results to Be Presented at the ASCO Annual Meeting
3. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
4. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
5. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
6. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
7. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
8. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
9. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
10. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
11. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
Post Your Comments:
(Date:7/11/2014)... , July 11, 2014  Veran ... company, announced today the positive, cost-effective final ... innovative SPiNPerc™ procedure. The SPiNPerc endobronchial percutaneous ... a percutaneous approach to biopsy when a ... patients and physicians experience positive financial outcomes ...
(Date:7/10/2014)... , July 10, 2014  The U.S. Department ... three-year grant to University Hospitals (UH) Case Medical Center ... new national model aimed at improving care for patients ... Care," the project will test a unique model developed ... with late-stage disease, significant comorbidities, or demonstrated need for ...
(Date:7/10/2014)... WEST JORDAN, Utah , July 10, 2014 /PRNewswire/ ... imaging solutions, and MiE America , Inc., a ... systems, have entered into a long-term agreement naming BC ... in the US. MiE and BC ... a strategic agreement to establish BC Technical as the ...
Breaking Medicine Technology:Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... - Finding May Refine Drug Targets for Personalized Treatments ... new genes that increase the risk of developing inflammatory,bowel ... needed to identify the specific disease-causing,mutations in these new ... to be added to the list of genes already,known ...
... centers to collaborate on studies of immunosuppression ... immunity, COLUMBIA, Md., Aug. 28 "Cylex, Inc., ... delighted to be able to,announce our support for a ... at seven highly respected medical institutions,in the Republic of ...
Cached Medicine Technology:New Genes Found for Inflammatory Bowel Disease in Children 2New Genes Found for Inflammatory Bowel Disease in Children 3New Genes Found for Inflammatory Bowel Disease in Children 4Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea 2Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea 3
(Date:7/12/2014)... Ladies, it doesn't matter what your budget is, ... looking for an affordable gown can visit Discount-Dress.com ... get their dream items. Recently, the company has announced its ... Along with that, it is also providing great discounts for ... the deadline of this promotion is July 29, 2014. ...
(Date:7/11/2014)... July 12, 2014 According to ... total market is expected to register a CAGR ... , Browse 71 market data tables and 76 ... on "C4ISR Market"., http://www.marketsandmarkets.com/Market-Reports/c4isr-market-1315.html , Early ... http://www.marketsandmarkets.com/requestCustomization.asp?id=1315 , The report provides market ...
(Date:7/11/2014)... 11, 2014 (HealthDay News) -- Reducing the number of ... of Lyme disease and other tick-borne infections among people, ... populations can be manipulated to reduce human interactions with ... Lyme disease," the researchers wrote. White-tailed deer are ... Lyme disease to people. The study included nearly ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Microbiology testing ... the in-vitro diagnostics industry, which is expected to pose ... years. The sector owes its growth to the ongoing ... people’s health worldwide and a major factor leading to ... threat of bio-terrorism, and a broader availability of immunosuppressants, ...
(Date:7/11/2014)... Datalogic brings a new and innovative scanner to ... their new Gryphon GD4400 and GM4400 anti-microbial ... MRSA, which claimed 5,500 lives, becomes more preventable. ... the Gryphon GM4400-HC 2D readers can scan nearly all ... off of troublesome LCD monitors, smartphones, and other mobile ...
Breaking Medicine News(10 mins):Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 4Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3
... ESA Envisat images capture the oil that is spilling into the ... the coasts of Louisiana and Mississippi, USA, on 22 April. ... a dark grey whirl in the bottom right, while in the ... Delta is at top left, and the Delta National Wildlife Refuge ...
... , ... to Support Acute Healthcare Services and Infection Control , ... Santa Clara, Calif. (PRWEB) April 27, 2010 -- ... announced today that Broomfield Hospital, part of Mid Essex Hospital Services NHS Trust, will ...
... ... during NACDS Annual Meeting , ... Palm Beach, FL (Vocus) April 27, 2010 -- In his first remarks as the newly ... ( NACDS ), Larry J. Merlo, president of CVS/pharmacy, paid tribute to the pharmacy icons ...
... age of iPads and hybrid cars, young Americans are more ... baby boom generation: They are living at home longer, are ... new study points out that a 22-year-old of today might ... or great-grandfather than their own parents, although the reasons for ...
... ... hundred hospitals, the medical demands of the residents of New York City are vast. ... City’s most important suppliers of donor blood and critical medical equipment rely on USPack Courier’s ... , ...
... for men with advanced disease, studies found, , TUESDAY, ... week of a therapeutic prostate cancer vaccine by the ... against the disease and cancer in general, experts say. ... in men with advanced prostate cancer, and it does ...
Cached Medicine News:Health News:NHS Mid Essex Prescribes Wireless Network For New Hospital Wing 2Health News:New NACDS Chairman Larry Merlo Emphasizes Personal Commitment, Connection to Pharmacy 2Health News:New NACDS Chairman Larry Merlo Emphasizes Personal Commitment, Connection to Pharmacy 3Health News:Lower wages, lack of job opportunities means more Americans delaying 'adulthood' 2Health News:Lower wages, lack of job opportunities means more Americans delaying 'adulthood' 3Health News:Lower wages, lack of job opportunities means more Americans delaying 'adulthood' 4Health News:USPack Courier Brings Tracking Precision to Medical and Blood Shipments 2Health News:USPack Courier Brings Tracking Precision to Medical and Blood Shipments 3Health News:Prostate Cancer Vaccine May Get FDA Approval 2Health News:Prostate Cancer Vaccine May Get FDA Approval 3
... for vascular treatments, Smart VS is the most ... fast amortisation of the investment made. Like all ... with a polarised light viewing system for ensuing ... as well as the operators maximum comfort. I ...
... is an exceptional condensate of ... dimensions for ensuring a rational ... constantly evolving professional market. PhotoLight ... in different studios who require ...
... 2000 system is a pulsed DYE laser ... specific pathologies like Port Wine Stains (PWS), ... pathologies of the trunk and the face. ... all these pathologies, the DYE laser naturally ...
... Plus is a CO2 laser system ... W. Its functions in continuous and ... requiring extreme laser intervention delicacy. Excellent ... studios, it comes with a large ...
Medicine Products: