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Synta Presents Results for STA-4783 in Metastatic Melanoma Showing,Improvement in Overall Survival

ll die of the disease this year," said Karen Graham, Chairman and President of the William S. Graham Foundation for Melanoma Research, Inc. ("The Billy Foundation"). "The five year survival rate for patients diagnosed with stage IV or metastatic disease can be less than 7 percent. We are very encouraged by the Phase 2b clinical trial results for STA-4783 and look forward to Synta initiating the Phase 3 trial in the coming months for first-line treatment of patients with metastatic melanoma."

Additional Survival Results from the Phase 2b Trial

A total of 81 patients were enrolled in the trial, which compared the effects of treatment with STA-4783 plus paclitaxel (N=53) to treatment with paclitaxel alone (N=28). Patients receiving paclitaxel alone were allowed to cross over to the experimental arm upon evidence of disease progression. Of the 28 patients initially treated with paclitaxel alone, 19 patients crossed over after their disease progressed, while 9 patients did not cross over.

Overall survival rates at one year were as follows:

-- STA-4783 + paclitaxel patients 49%

-- Cross-over STA-4783 + paclitaxel patients 53%

-- Patients who did not receive STA-4783 22%

The one-year survival rate for patients treated with STA-4783 compares favorably with results from the only approved chemotherapy for metastatic melanoma, dacarbazine (DTIC). In four recently published randomized, controlled trials, the one-year survival rates for patients treated with DTIC were 15%, 22%, 27%, and 30%, respectively (2).

The median overall survival times, measured in months from time of initial randomization into the trial, were:

-- STA-4783 + paclitaxel patients 12.0

-- Cross-over STA-4783 + paclitaxel patients 14.3

-- Patients who did not receive STA-4783 5.6

The median overall survival times also compare favorably with results from prior trials. Median overall survival times in the recent randomized, cont
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