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Synta Presents Results for STA-4783 in Metastatic Melanoma Showing,Improvement in Overall Survival

LEXINGTON, Mass.--(BUSINESS WIRE)--Jun 5, 2007 - Synta Pharmaceuticals Corp., (NASDAQ: SNTA) a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced encouraging results from the analysis of overall survival (OS) time for patients in the Company's double-blind, randomized, controlled, multi-center Phase 2b clinical trial in metastatic melanoma for its lead compound, STA-4783.

The analysis of overall survival showed that patients randomized to receive STA-4783 plus paclitaxel (N=53) experienced a median survival of 12 months, compared to 7.8 months for all patients who initially received paclitaxel alone (N=28). The Phase 2b trial included a crossover design that allowed patients who initially received paclitaxel alone to receive STA-4783 plus paclitaxel following evidence of a worsening of their disease. Of the 28 patients who initially received paclitaxel alone, 19 elected to subsequently receive STA-4783. The median overall survival for this group was 14.3 months. By contrast, the group of patients initially treated with paclitaxel alone who did not subsequently receive STA-4783 experienced a median survival of 5.6 months. Other randomized trial results in metastatic melanoma have consistently shown a median survival time of between six and nine months regardless of treatment (1).

"The new overall survival results reinforce the previously-reported positive results from this trial, including meeting the primary endpoint of progression free survival (PFS) and showing substantial improvement in tumor response rate," said Safi Bahcall, Ph.D., President and Chief Executive Officer of Synta. "The collective results on the anti-cancer activity of STA-4783 in metastatic melanoma, together with the favorable safety profile, are very encouraging and suggest that this novel mechanism compound has potential as an im
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