( it. SNS-032 is a potent selective i...)Sunesis Pharmaceuticals Reports Positive Data From Studies of Two,Anti-Cancer Agents, SNS-595 and SNS-032, at the 12th Congress of,the European Hematology Association,Health

SNS-032 is a potent, selective inhibitor of CDKs 2, 7 and 9 that inhibits both cell cycle progression and transcription of anti-apoptotic signals key to the survival of B-cell malignancies. SNS-032 is currently being studied in a Phase 1 dose-escalation safety trial in patients with B-cell malignancies, including chronic lymphocytic leukemia, mantle cell lymphoma and multiple myeloma. Sunesis plans to present preliminary data from this ongoing Phase 1 trial by year's end.

Data on SNS-595 and SNS-032 were presented at the 12th Congress of European Hematology, organized by The European Hematology Association (EHA) on Saturday, June 9, 2007 in two poster sessions:

    -- Abstract #0489: "Pharmacokinetic/Pharmacodynamic Correlation with

       Responses in a Phase 1 Study of Patients with Relapsed/Refractory Acute

       Leukemias Treated with SNS-595"

    -- Abstract #0742: "SNS-032 Exhibits Dose-Dependent Mechanism-Based

       Inhibition of CDK7 and CDK9 in Peripheral Blood Mononuclear Cells from

       Patients with Advanced Cancers Treated in an Ongoing Phase 1 Trial"

About Sunesis' Oncology Programs

Sunesis has built a rich portfolio of product candidates in oncology focused on novel pathways and targets, including inhibition of the cell-cycle and survival signaling. Sunesis is currently conducting Phase 2 clinical trials in lung and ovarian cancer and a Phase 1 clinical trial in acute leukemias for its lead compound, SNS-595. SNS-032, a selective inhibitor of cyclin-dependent kinases 2, 7 and 9, is being evaluated in Phase 1 clinical trials in B-cell malignancies and in advanced solid tumors. The company's Aurora kinase inhibitor, SNS-314, is expected to begin Phase 1 clinical trials in mid-2007. In addition, Sunesis is developing novel small molecule inhibitors of Raf kinase and other oncology kinases in collaboration with Biogen Idec.

About Sunesis Pharmaceuticals

Sunesis is a clinical-stage biop
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