Navigation Links
Sunesis Pharmaceuticals Reports Positive Data From Studies of Two,Anti-Cancer Agents, SNS-595 and SNS-032, at the 12th Congress of,the European Hematology Association

om non-clinical studies demonstrates that SNS-595 and cytarabine act synergistically to ablate bone marrow in experimental models while sparing normal hematopoietic recovery. Sunesis plans to initiate a Phase 1b clinical trial of SNS-595 in combination with cytarabine in patients with advanced acute leukemias in the third quarter of this year.

Non-clinical Results Compare CDK-Inhibitor SNS-032 to Flavopirodol

In a second presentation, Sunesis reported the results of studies evaluating its cyclin-dependent kinase (CDK)-inhibitor, SNS-032, which demonstrated that SNS-032 has greater selectivity and cellular potency to other CDK-targeting agents, such as flavopiridol and seliciclib. SNS-032 was analyzed against flavopiridol in a cancer cell line in bovine and human serum to assess mechanism of action and target modulation. SNS-032 was observed to be a more potent inhibitor of CDK9 and to possess greater pro-apoptotic activity than flavopiridol in human serum. In addition, mechanism-based, dose-dependent target modulation indicating CDK7 and CDK9 inhibition, as well as down-modulation of the survival signaling protein Mcl-1, was observed in peripheral blood cells obtained from patients treated with SNS-032 in a Phase 1 solid tumor clinical trial. These data further differentiate SNS-032 from flavopiridol.

"Results from these studies distinguish SNS-032 from other CDK inhibitors being tested in the clinic. Data presented on SNS-032 from comparative studies show this promising product candidate is hitting its molecular targets, including Mcl-1, in peripheral mononuclear cells taken from patients undergoing treatment in a dose-dependent fashion," said Dr. Adelman. "Our observations relating to SNS-032's mechanism support the ongoing Phase 1 clinical trial of SNS-032 in B-cell malignancies. This Phase 1 trial is designed to test our hypothesis that targeted inhibition of survival signaling in hematologic diseases will result in meaningful clinical benef
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
2. Sunesis Pharmaceuticals to Present Data at the 12th Congress of the European Hematology Association
3. Sunesis Presents Data Supporting SNS-032s Potential Anticancer Activity in Multiple Myeloma at the American Association for Cancer Research Meeting
4. Sunesis Pharmaceuticals to Present Data at the Annual Meeting of the American Association for Cancer Research
5. Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor Data Showing Broad Anti-Tumor Activity, Dosing Flexibility
6. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
10. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
Post Your Comments:
(Date:7/28/2014)... -- Concord Medical Services Holdings Limited ("Concord Medical" or ... specialty hospital management solution provider and operator of the ... China , today announced that on ... special cash dividend of US$0.30 per ordinary share (or ... outstanding ordinary shares. The total expense for the special ...
(Date:7/28/2014)... TOKYO , July 28, 2014  ImaginAb, Inc. ... Roger Crystal , MD as Vice President of Business ... Business Development Product Acquisition & Licensing team at G.E. ... business strategy and partnerships in the precision medicine space ... with biotechnology and pharmaceutical companies across the spectrum to ...
(Date:7/28/2014)... 2014   Cardioxyl Pharmaceuticals, Inc. announced today ... CXL-1427, a novel potential treatment for acute decompensated heart ... company has now initiated dosing of hospitalized patients with ... designed to further evaluate the drug,s safety and tolerability ... Phase I clinical trial evaluated the safety and tolerability ...
Breaking Medicine Technology:Concord Medical Declares Special Dividend 2ImaginAb Appoints Roger Crystal, MD as Vice President of Business Development 2Cardioxyl Pharmaceuticals Successfully Completes First Clinical Trial For Heart Failure Drug CXL-1427 2
(Date:7/29/2014)... Lean and Lovely, an affordable and short program, claims ... wear a bikini in the near future. This has caught ... , “Our Lean and Lovely review shows that ... levels. Neither your age nor your body shape matters, which ... the beginning, you will achieve the results that you have ...
(Date:7/29/2014)... 29, 2014 Current Back2Basics long-term drug ... medication post foot surgery during his first six months of ... surgery – twice on one foot, once on the other– ... broke my foot a year ago and was prescribed drugs ... Jon by a friend from home who’d recently completed the ...
(Date:7/29/2014)... PeopleKeys today announced that they are launching ... to train and certify others in applied DISC behavioral ... , will be taught by PeopleKeys Master Coach Dan ... as a live Tele-course over the span of 10 ... Consultant Trainer course will use a combination of real-time ...
(Date:7/29/2014)... Maui, HI (PRWEB) July 29, 2014 Couples ... Seasons Resort Maui at Wailea. This September through November, ... of them free-- tailored to couples of all ages and ... and guests can take advantage of the Resort's popular ... $1,000 while the "twice yearly sale" is in full swing ...
(Date:7/29/2014)... 2014 In today’s world, a good night’s ... Snoring and sleep apnea (a medical problem where the airway ... bed partners of the rest they need to face their ... snores and 20 million people in the United States alone ... and treated; and of those treated, many cannot tolerate their ...
Breaking Medicine News(10 mins):Health News:Lean and Lovely: Review Examining Neghar Fonooni’s Program Released 2Health News:Back2Basics Sober Living Resident Overcomes Obstacle in Early Sobriety 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 3Health News:Four Seasons Resort Maui at Wailea Goes All Out to Give Couples Memorable Get-Away this Fall at Maui’s Luxury Resort 2Health News:Four Seasons Resort Maui at Wailea Goes All Out to Give Couples Memorable Get-Away this Fall at Maui’s Luxury Resort 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3
... , Anti-Abortion Extremist Ejected After "Murder" ... night in northern Virginia, Representative James Moran and Governor Howard Dean ... by thousands of people. Anti-abortion extremist Randall Terry, the founder of ... be there to disrupt it by accusing President Obama of "killing ...
... reporting development of a new electronic sensor that shows promise ... tests now used to detect DNA. Such tests are ... new lab-on-a-chip test could lead to wider, more convenient use ... for the Sept. 2 issue of the Journal of ...
... Fla., Aug. 26 The only effective solution with proven performance to manage ... The RISS System(TM) removes the inorganic and organic sulfur based contaminants ... it is in Patent Pending status with the U.S. Office of Patents and ... www.RISS s y s tem . com ...
... , , LOS GATOS, Calif., Aug. 26 ... how she survived an airplane crash. Inspiring her audiences with her experience ... Bay area September/early October. , , She says, ... My life was full of stress, illness and failure. After major surgery ...
... , JERICHO, N.Y., Aug. 26 Optimum ... New York metropolitan area businesses, today announced that Medical ... in Long Island, has selected Optimum Lightpath as its ... Optimum Lightpath,s 100% fiber Ethernet connection, Medical Arts Radiology ...
... MORRIS PLAINS, N.J., Aug. 26 New entries in the eye ... eyes. , , "Eye irritation comes in ... including indoor and outdoor irritants and allergens like dust, pollen and ragweed, ... Brisco, O.D. "Since many people experience more than one symptom ...
Cached Medicine News:Health News:Randall Terry Removed By Police From Howard Dean Health Care Town Hall Meeting 2Health News:Proven Solution for Chinese Drywall is Now Available 2Health News:Australia's Contribution to Health and Ultra-longevity 2Health News:Medical Arts Radiology Chooses Optimum Lightpath to Speed Anytime, Anywhere Access to Patient Data and Communications 2Health News:Medical Arts Radiology Chooses Optimum Lightpath to Speed Anytime, Anywhere Access to Patient Data and Communications 3Health News:Breakthroughs in Eye Care Products Offer Fresh Approach for Soothing Eyes 2
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
... 48-capillary 3730 DNA Analyzer, upgradeable to 96 ... DNA analysis. , Higher optical sensitivity ... higher-quality data at a lower cost. , ... , Optimized polymers increase your productivity without ...
The Pipetman Large-Volume Kit includes two large-volume pipettes conveniently packaged with filters and tips at an exceptional price....
... an immunochromatography based one step in vitro ... Opiates and its metabolite in human urine,specimens. ... above a cut-off level of 300 ng/mL,can ... evaluated in the point of care location ...
Medicine Products: