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Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility

imal regimen for treating tumors in the clinic.

At the Keystone Symposia "Molecular Targets for Cancer" meeting in Whistler, British Columbia, Canada, results from studies of SNS-314's mechanism of action and activity in tumor cell lines were presented in a poster. Data presented at both the Keystone and TAT scientific meetings reported that SNS-314 is a selective and potent (IC50s in the low nanomolar range) inhibitor of Aurora kinases A, B, and C in vitro. In addition, SNS-314 was shown to have sustained exposure in tumor tissue, further supporting the compound's potential to differentiate its anti-tumor effects from effects on other proliferating tissues.

Discovered by Sunesis, SNS-314 is targeted to inhibit Aurora kinases thus halting cell division at the mitotic phase of the cell cycle and blocking the uncontrolled cellular proliferation associated with tumor growth. Aurora kinases have been detected at high levels in tumors from several cancer types, including colon, breast, ovarian, bladder, esophageal, gastric and pancreatic. Sunesis recently filed an Investigational New Drug Application with the U.S. Food and Drug Administration (FDA) for SNS-314 and the company expects to initiate a Phase 1 single-agent clinical trial in patients with advanced solid tumor malignancies in the first half of this year.

About Sunesis' Oncology Programs

Sunesis has built a rich portfolio of product candidates in oncology focused on novel pathways and targets, including inhibition of the cell-cycle and survival signaling. Sunesis is currently conducting Phase 2 clinical trials in lung and ovarian cancer and a Phase 1 clinical trial in acute myeloid leukemia for its lead compound, SNS-595. SNS-032, Sunesis' CDK inhibitor compound, is being evaluated in Phase 1 clinical trials in B-cell malignancies and in advanced solid tumors. SNS-314 is expected to begin Phase 1 clinical trials in the first half of 2007. In addition, Sunesis is developing novel small
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