Navigation Links
Study of Drug Therapy for Compulsive Buying Yields a Puzzle,,Stanford Researcher Says

STANFORD, Calif.--(BUSINESS WIRE)--Mar 14, 2007 - Researchers at the Stanford University School of Medicine say they are puzzled by findings from their new study indicating that an antidepressant, which previously showed promise in treating a behavioral disorder known as compulsive buying, did not result in a sustained benefit for the patients who took it.

The medication is escitalopram, a commonly prescribed antidepressant sold under the brand name Lexapro. In the study, researchers found no difference in the relapse rate of people with compulsive-buying disorder when they continued to take escitalopram compared with those who had been switched to a placebo. Those results are perplexing to lead author Lorrin Koran, MD, professor of psychiatry and behavioral sciences emeritus, because he had done a similar study in 2003 that found compulsive-buying patients improved stably after taking another antidepressant medication, citalopram, in which escitalopram is the active ingredient.

"It was a shock that, when we did the trial again with the active ingredient, it didn't work exactly the same way. It should have," said Koran, who also led the 2003 study. The results of the latest double-blind, placebo-controlled trial will be published in the April issue of the Journal of Clinical Psychopharmacology.

Koran said the unexpected result from the new study may in part be due to the small number of participants in the double-blind phase of the trial, which involved just 17 subjects whose buying behavior had markedly improved in the initial stage of the trial when they were all taking escitalopram. Of the nine randomly assigned to take a placebo in the later part of the trial, six relapsed, while five of eight continuing on escitalopram relapsed.

But the study size is likely not the only factor influencing the outcome of the trial.

"I don't think we're dealing with one pure biological disorder," said Koran. "We're dealing with a behavior that has different biological roots in different people and therefore we may have had very different groups of people in the two studies."

In the 2003 study, 24 patients were all initially given citalopram for the open-label portion of the study, during which they all knew they were taking citalopram. Fifteen of those patients reported marked improvements in their buying behaviors. For the second portion of that trial, these 15 patients were randomly assigned to take either citalopram or a placebo without knowing which one they were taking. Of seven patients who continued taking the medication, all seven maintained their improvement, while five of the eight patients receiving a placebo relapsed.

People suffering from compulsive buying disorder are preoccupied with shopping for unneeded items and are frequently unable to resist purchasing them. The problem is not a simple lack of willpower, said Koran, who described it as being as real a disorder as other impulsive behaviors such as alcoholism and pathological gambling. Sufferers of the disorder commonly wind up with closets or rooms filled with unwanted purchases, amassing thousands of dollars of debt in the process and often damaging their relationships by lying to loved ones about their purchases.

A recent nationwide, random-sample telephone survey conducted by Koran and his colleagues indicated that compulsive buying appeared to affect nearly 6 percent of the U.S. population, with nearly equal proportions of men and women affected.

Koran said a larger double-blind, placebo-controlled clinical trial is needed to reach a conclusive result regarding the effectiveness of escitalopram in treating patients with compulsive buying disorder.

He suggested future clinical trials might be able to yield more information if they were combined with imaging studies of the patients' brains. He cited recent work by Brian Knutson, PhD, assistant professor of psychology and neuroscience, whose recent imaging studies suggest that scientists might be able to directly visualize brain activity related to compulsive purchases.

"We would look for a difference in the brain activation patterns of those who respond to the drug vs. those who don't," said Koran.

The inconclusive nature of the results from the latest trial of escitalopram should not discourage anyone suffering from compulsive buying from seeking treatment, since several types of treatment seem to be helpful, Koran emphasized.

This study was funded by Forest Laboratories, which makes and markets escitalopram under the name Lexapro, and citalopram under the name Celexa. Koran has served as a paid speaker for Forest Laboratories, as has second author Elias Aboujaoude, MD, clinical assistant professor of psychiatry and behavioral sciences and director of Stanford's Impulse Control Disorders Clinic.

Other co-authors include Hugh Brent Solvason, MD, assistant professor of psychiatry and behavioral sciences; Nona Gamel, clinical research manager; and Emily Smith, clinical research coordinator.

Stanford University Medical Center integrates research, medical education and patient care at its three institutions -- Stanford University School of Medicine, Stanford Hospital & Clinics and Lucile Packard Children's Hospital at Stanford. For more information, please visit the Web site of the medical center's Office of Communication & Public Affairs at http://mednews.stanford.edu.

Contact

Stanford University Medical Center
Louis Bergeron, 650-724-2454 (Print Media)
louisb3@stanford.edu
M.A. Malone, 650-723-6912 (Broadcast Media)
mamalone@stanford.edu


'"/>




Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... NEW YORK , December 2, 2016 ... at 5,251.11, down 1.36%; the Dow Jones Industrial Average edged ... closed at 2,191.08, down 0.35%. Losses were broad based as ... Today, Stock-Callers.com has initiated research reports on the following Services ... N.V. (NASDAQ: QGEN ), INC Research Holdings Inc. ...
(Date:12/2/2016)... -- UCB is pleased to announce that 12 scientific abstracts have ... American Epilepsy Society (AES) Annual Meeting, which takes place ... USA. 1-12 Data being presented include ... ® (lacosamide) CV and BRIVIACT ® (brivaracetam) CV. ... state of the union of epilepsy care and antiepileptic drugs ...
(Date:11/30/2016)... 30, 2016 Research and Markets ... for Neuromodulation, Neurovascular, Neurosurgical and Monitoring Devices 2017 - MedView" ... ... The full report suite on the U.S. market for ... systems, intracranial pressure monitoring devices, detachable coils, liquid embolics, catheters, ...
Breaking Medicine Technology:
(Date:12/2/2016)... ... 2016 , ... More than half of American teens report losing their virginity ... with their child about sex related topics, less than 60 percent spoke about deeper ... announce the launch of its second edition of the “Sexual Wellness” campaign, aiming to ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal Medical ... systems and the first company to offer robotic imaging to veterinary medicine is ... booth # 941 for the American Association of Equine Practitioners 62nd Annual Convention ...
(Date:12/2/2016)... ... ... "Pro3rd Accents Volume 2 is a set of 30 accented lower third ... a few clicks of the mouse," said Christina Austin - CEO of Pixel Film ... various styles with accented animations, rigid boxes, simplistic lines, and more. In Addition, users ...
(Date:12/2/2016)... ... December 02, 2016 , ... Date aired: November 28, ... 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein , Sharon Kleyne, America’s ... Global Climate Change and Your Health radio program syndicated on Voice of America, ...
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the mixture of saliva and ... said an inventor from Bridgewater, N.J. "I thought that there had to be a ... He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste from running down the ...
Breaking Medicine News(10 mins):