Navigation Links
Study in Cell by Magen BioSciences Co-Founder David E. Fisher,Identifies New Roles in Skin Cancer Prevention for Key Tumor,Suppressor Protein

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Mar 8, 2007 - Magen BioSciences, Inc., a specialty dermatology company, today announced the publication of a paper in the March 9, 2007 issue of the journal Cell by its co-founder and board member, David E. Fisher, M.D., Ph.D., that identifies two new functions for an important protein, p53, in the pigmentation of skin. Fisher's study shows that in addition to its function as a tumor suppressor in other cancers in the body, p53 also plays a key role in prompting the skin to tan in response to ultraviolet light from the sun. By promoting tanning, p53 deters the development of the skin cancer melanoma, which is increasing in incidence faster than any other cancer in the world.

Fisher's research also shows that p53 causes the production of an endorphin after ultraviolet exposure, and this may modulate sensation in the skin in a manner that influences behaviors, possibly including sun-seeking behaviors.

For Magen BioSciences, the study in Cell provides important proof of concept for the company's approach to identify and develop therapeutic treatments for pigmentation disorders.

"We know that people who tan easily or have dark pigmentation are far less likely to develop melanoma," said David Fisher, with the Dana-Faber Cancer Institute. "This study suggests that p53, one of the best-known tumor-suppressor proteins in our body, goes into action when skin cells experience UV exposure, prompting the skin to tan as a defensive mechanism against DNA damage and at the same time creating endorphins that may alter sensation or even behavior."

"Dr. Fisher's discovery of this new function for a well-known protein sheds new light on the mechanism and function of tanning," said Brian Gallagher, Ph.D., Magen's president and chief executive officer. "This discovery will help Magen BioSciences identify lead compounds and develop therapeutic treatments for disfiguring dermato
'"/>




Page: 1 2

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
(Date:12/19/2014)... Ill. , Dec. 19, 2014   Hospira, ... leading provider of injectable drugs and infusion technologies, today ... Morgan 33rd Annual Healthcare Conference on Wednesday, Jan. 14, ... presentation is scheduled to begin at 10:30 a.m. Pacific ... available to all interested parties through a live audiocast ...
(Date:12/19/2014)... SAN DIEGO and CARDIFF-BY-THE-SEA, ... Therapeutics, Inc. (NASDAQ: SRNE ;  Sorrento), ... and associated pain, and Conkwest, Inc., a privately-held ... a Natural Killer (NK) cell-line based therapy, announced ... definitive agreement to jointly develop next generation CAR-TNK™ ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ... generation of equipment for the testing of marijuana ... of the new Luminary™ Profiler, the industry,s first ... measurement in a cost-effective, portable unit. ... specific needs of the cannabis industry, the Luminary™ ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... YORK, July 8, 2011 The U.S. Food and ... Diphtheria Toxoid, and Acellular Pertussis Vaccine, Adsorbed (Tdap)] for ... for active booster immunization against tetanus, diphtheria and pertussis ... vaccine approved for use in this age group.  With ...
... July 8, 2011 /PRNewswire-Asia/ -- Shenzhen Wuzhou Changlian International ... of multifunctional medical and industrial products, is pleased to ... Up to a 35% discount will be offered in ... promotional activity range from infrared thermometers , digital ...
Cached Medicine Technology:GlaxoSmithKline Receives FDA Approval for BOOSTRIX® to Help Prevent Whooping Cough in Adults 65 Years and Older 2GlaxoSmithKline Receives FDA Approval for BOOSTRIX® to Help Prevent Whooping Cough in Adults 65 Years and Older 3GlaxoSmithKline Receives FDA Approval for BOOSTRIX® to Help Prevent Whooping Cough in Adults 65 Years and Older 4Enjoy Only One Thermometer in Various Domains 2
(Date:12/21/2014)... 2014 Khanna Vision Institute is pleased ... the Aspen Helicopters holiday event for underprivileged kids. The ... sleigh, flown by an aspen helicopter pilot. In the ... with sleigh was visible.(please see accompanying video). Helicopter pilots ... has helped many pilots with Pi in eye vision ...
(Date:12/21/2014)... Recently, one of the best prom ... Shop has introduced its new collection of 2015 ... discounts on all its prom dresses & other fashionable ... on providing top quality dress products and great customer ... as one of the best prom dresses online shops ...
(Date:12/21/2014)... 21, 2014 Over the past 39 ... in hundreds of emergency departments across the nation, from ... have been translated into an innovative suite of tools, ... deficiencies and enhance the patient experience. , NES ... staffing and management services for hospitals, announced the development ...
(Date:12/21/2014)... 2014 The Oncology Institute of Hope and ... Ana and Whittier offices. The Hope for the Holidays Toy ... patients and their families during the holiday season. This year, ... 70 children between both offices. This event continues to be ... community service team, store managers and assistant managers came out ...
(Date:12/20/2014)... has recently announced its new collection of sweet 16 ... dresses for the coming new year. , Weddingshe.com ... global women. Now, all the models on its website ... Among the new items, the model of 10986064 (Fresh ... popular. What’s more, Weddingshe.com also provides a fast and ...
Breaking Medicine News(10 mins):Health News:New Prom Dresses From One Of The Best Prom Dresses Online Shops, LunaDress Prom Shop 2Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2
... , CHICAGO, Sept. 9 Millennium Pharmacy Systems, a leading ... was named to Inc. Magazine,s Inc. 500 list of the ... the third consecutive year. Millennium qualified based on its extraordinary 737.5% ... care pharmacy services provider to make the list. , ...
... , , NEW YORK, ... that it is providing a grant of $200,000 to Abiant, Inc. ... for Alzheimer,s Disease. Abiant, a privately held company, is dedicated ... of neurologic and neuropsychiatric disorders. , , ...
... Rally Against Obamacare , , WASHINGTON, Sept. 9 ... working for a healthcare system that ensures the highest quality and affordable care ... nation for this event and press conference. , , ... When: Thursday, September 10, 2009 , , ...
... , , CINCINNATI, Sept. 9 ... to know that healthful aging depends on our current habits. ... we take precautionary measures to strengthen ourselves," explains the women,s health ... bones are all areas that are often overlooked or taken for ...
... , , NEW YORK, Sept. 9 ... their lifetime. Shape magazine encourages everyone to join the ... Pilates for Pink initiative kicks off! This award-winning fundraiser enables ... , , Shape and The Breast Cancer ...
... HARBIN, China, Sept. 9 /PRNewswire-Asia-FirstCall/ -- China Kangtai ... grower,developer, manufacturer and marketer of a variety of cactus-based ... Annual Global Investment,Conference to be held on September 9-11, ... as part of the Asia Track program on September ...
Cached Medicine News:Health News:Millennium Pharmacy Systems Named to Inc. 500 for Third Consecutive Year 2Health News:Alzheimer's Drug Discovery Foundation Funds Abiant, Inc. to Develop a Positron Emission Tomography (PET) Imaging Diagnostic for Alzheimer's Disease 2Health News:Alzheimer's Drug Discovery Foundation Funds Abiant, Inc. to Develop a Positron Emission Tomography (PET) Imaging Diagnostic for Alzheimer's Disease 3Health News:Leading Women's Health Expert Offers Preventive Tips for Healthful Aging 2Health News:Leading Women's Health Expert Offers Preventive Tips for Healthful Aging 3Health News:Leading Women's Health Expert Offers Preventive Tips for Healthful Aging 4Health News:Get Fit, Give Back 2Health News:Get Fit, Give Back 3Health News:China Kangtai Cactus Biotech to Present at the Rodman & Renshaw Annual Global Investment Conference in New York on September 11, 2009 2Health News:China Kangtai Cactus Biotech to Present at the Rodman & Renshaw Annual Global Investment Conference in New York on September 11, 2009 3
... for the semi-quantitative determination of specific IgA ... results of the anti-Gliadin IgA assay can ... diagnosis of diseases associated with elevated levels ... of these autoantibodies are one indicator in ...
... a high throughput primary or backup ... offers performance and reliability equal to ... instruments. The advanced technology of the ... strips delivers reproducible and accurate results, ...
... was originally developed for the World Health ... function. It has been widely used in ... natural family planning methods. Urine samples are ... measured by EIA (enzyme labelled immunoassay with ...
... 10-8700 ACTIVE® Estrone Enzyme Immunosorbent Assay ... quantitative measurement of Estrone in serum. ... of enzyme immunoassay where there is ... an enzyme-labeled antigen for a fixed ...
Medicine Products: