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Study Suggests Invega Helps Patients With Schizophrenia Maintain,,,Symptom Control

tolerability for INVEGA in the treatment of patients with schizophrenia. In this study, participants were treated with flexible doses of INVEGA (3mg to 15mg once daily, with 9mg as the starting dose) after concluding their previous double-blind study treatment. The study population was segmented into three subgroups based on treatment experience during the previous six-week trials: placebo to INVEGA; INVEGA to INVEGA; and olanzapine to INVEGA.

Because there were more INVEGA active treatment groups in the short-term efficacy trials, most patients entering this OLE study had previously received short-term treatment with INVEGA. Patient groups receiving INVEGA in the short-term efficacy trials were shown to have significantly improved by the end of short-term treatment when they became eligible to enter the OLE study, both in symptoms and in functioning, compared to placebo. In total, 47 percent of patients completed the longer-term 52-week OLE study.

Efficacy analyses included change from baseline to end point in Positive and Negative Syndrome Scale (PANSS)* total score and the Personal and Social Performance (PSP)** scale, a measure of personal and social functioning.


    EFFICACY ASSESSMENTS



    PANSS



    - Improvements in PANSS total score in all treatment groups were observed



      over the first 12 weeks of the OLE study and were maintained throughout



      the remainder of the 52-week trial



    - Mean PANSS total scores improved from open-label baseline most notably



      in patients in the placebo-to-INVEGA group





    PSP Scale



    - The improvements seen in patient personal and social functioning during



      the six-week placebo-controlled trial, were maintained over the 52-week



      period.



"The pooled efficacy data suggest to me that long-term treatment with INVEGA helps to sustain symptom control and social function
'"/>




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