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Study Shows Metabolic Strategy of Stressed Cell

ndria-the powerhouses of the cell.

"We identified the metabolic rearrangements the cell undergoes to ensure that the liver keeps CoA levels high enough to produce glucose and the cells of the body maintain enough free CoA for the mitochondria to keep producing ATP," said Yong-Mei Zhang, Ph.D., of the St. Jude Infectious Diseases department and first author of the report.

Other authors of this paper include Shigeru Chohnan (St. Jude), Kristopher G. Virga and Richard E. Lee (University of Tennessee Health Science Center, Memphis, Tenn.); Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, James R. Bain and Christopher B. Newgard (Duke University Medical Center, Durham, N.C.).

This work was supported in part by the National Institutes of Health, a Cancer Center (CORE) Grant and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.

CONTACT: Public relations, Carrie Strehlau, +1-901-495-2295 or, Summer Freeman, +1-901-495-3061 or, Scientific Communications, Marc Kusinitz, Ph.D.,+1-901-495-5020 or , all of St. Jude Children'sResearch Hospital carrie.strehlau@stjude.org summer.freeman@stjude.org marc.kusinitz@stjude.org
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