Navigation Links
Study Shows Metabolic Strategy of Stressed Cell

Major St. Jude Study of Changes in Gene Activity and Metabolic Enzymes Show How Cells Respond to a Sudden Decrease in the Levels of Coenzyme A, a Key Player in the Daily Biochemical Routines that Support Life

MEMPHIS, Tenn., March 23, 2007 /PRNewswire/ -- Investigators at St. Jude Children's Research Hospital have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.

The results provide the most detailed look ever obtained of the complex metabolic changes in a cell triggered by a potentially fatal stress. CoA plays key roles in the cell's metabolism by participating in biochemical reactions in specific areas throughout the cell.

"The study provides the first detailed look at how the cell shifts genetic gears to respond to a significant change in its ability to carry on its daily metabolic chores," said Suzanne Jackowski, Ph.D., a member of the St. Jude Infectious Diseases department and the paper's senior author.

The St. Jude study is a significant contribution to the growing field of metabolomics -- the study of the molecules involved in metabolism, added Charles Rock, Ph.D., a member of the St. Jude Infectious Diseases department and co-author of the paper. Coupled with genetic studies of the cell, metabolomics is giving scientists a more detailed picture of how the body maintains its health in both normal environments and during times of stress, such as starvation or disease.

A report on this work appears in the March issue of "Chemistry and Biology."

The researchers studied the response to decreased CoA in a mouse model by blocking CoA production. Following the shutdown of CoA production, the cells quickly recycled CoA from other jobs so it could concentrate all its efforts on a single task: extracting life-supporting energy from nutrients in the mitocho
'"/>




Page: 1 2 3

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Shows Metabolic Strategy Stressed Cell
(Date:7/11/2014)... 2014 According to a ... of Material, Application (Healthcare, Homeland security, Industrial application, ... Instrument, Hand-Held Instruments, Fixed, and Installed Instruments) & ... published by MarketsandMarkets, the Scintillator Market is expected ... 2014 to 2020, and reach $479.16 Million in ...
(Date:7/11/2014)... -- Australian drug delivery company, Phosphagenics Limited (ASX: POH; OTCQX: ... via a placement of A$16.3 million to institutional investors ... Asia and Australia ... (SPP) to be offered to existing shareholders.  The placement ... "This capital raising positions us strongly to ...
(Date:7/11/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/tjlw9k/immunoprotein ) has ... Testing Market - Forecasts to 2019: Expected to ... is expected to be valued at USD 4,943.0 ... http://photos.prnewswire.com/prnh/20130307/600769 The ... according to immunoprotein types which include immunoglobulins, complement ...
Breaking Medicine Technology:Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
... , NEW YORK, ... market research report is available in its catalogue: ... Pharmaceuticals - Current and Future Market Outlook, Regulatory ... , Summary , The author ...
... , NEWNAN, ... specialty surface treatments for medical devices and of specialty implants, ... Gordy, will give an opening address for the Technology Parade ... Israel. "We must leave the era of petty self-interest ...
Cached Medicine Technology:Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 2Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 3Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 4Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 5Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 6Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 7Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies 8CeloNova BioSciences CEO Urges More Heart, More Passion, More Honesty, and All Urgency in Developing Medical Devices 2
(Date:7/14/2014)... Barbara Bronson Gray HealthDay ... -- New research suggests that a faltering sense of ... and that an inexpensive, low-tech smell test could spot ... two different studies, the decreased ability to identify odors ... and progression to Alzheimer,s disease. "We,re trying to ...
(Date:7/14/2014)... By Kathleen Doheny ... -- Losing a spouse may be linked to multiple health ... new study. For certain seniors, widowhood may even delay ... mild memory problem, losing the spouse was associated with a ... stayed married," said study researcher Dr. Bryan Woodruff. ...
(Date:7/14/2014)... Greenwich, Connecticut (PRWEB) July 14, 2014 ... Medic is celebrating its Grand Opening on Monday, ... Greenwich, Connecticut 06830. The celebration will last all ... for all new patients. Everyone is welcomed to ... Soika, M.D. who provides physician-administered skincare, anti-aging, weight ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 Many people ... people undergo plastic surgery to reduce a “double chin.” ... however, eliminates the need to go under the knife. ... works the jaw muscles, therefore tightening the skin in ... chins. , Jawflex is used for facial exercise, double ...
(Date:7/14/2014)... July 14, 2014 Since 1986, the ... icon to the Tysons Corner skyline and a staple ... own municipality, known simply as “Tysons”, the iconic hotel ... In addition to Tysons becoming its own municipality, ... the heart of Tysons brings an evolution of great ...
Breaking Medicine News(10 mins):Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 2Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 3Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 3Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3Health News:Jawflex | Double Chin Exercise for Double Chin Reduction 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 2Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 3Health News:Iconic Tyson’s Corner Hotel Embraces the New “Tysons” Evolution 4
... Study finds fewer complications with electrophysiologists , , TUESDAY, April ... of electrophysiology, but it,s a medical subspecialty you should ... or so Americans who will have a heart defibrillator ... when needed to keep an aberrant heart beating regularly. ...
... 21 DaVita Inc. (NYSE: DVA ... for those diagnosed with chronic kidney disease (CKD), ... the company,s Senior Vice President of Federal Legislative ... policy efforts in Washington, D.C. and report to ...
... April 21 New research with actionable insights on ... is now available in the Best Practice Database, an ... Best Practices, LLC.To review key topics in these studies, ... of the two new studies at this address: ...
... NASA,s newest piece of astronaut fitness gear headed for the ... that wants to avoid too many house calls for repairs. ... without a belt change."The COLBERT represents the integrated efforts of ... and very critical piece of flight hardware," said Jim Kukla, ...
... 21 On Wednesday, April 22, 2009 GlaxoSmithKline plc (NYSE: ... results for the three months ended March 31, 2009. ... the London Stock Exchange at approximately 7:00 AM EDT.At ... Julian Heslop, Chief Financial Officer will hold a briefing meeting ...
... an object to see it better, they lose the wide-angle ... context for detail. But now an imaging method developed by ... of the scene at once in the same high detail. ... other optical devices. , "It allows you to take ...
Cached Medicine News:Health News:Doctor's Training Affects Defibrillator Implant Results 2Health News:Doctor's Training Affects Defibrillator Implant Results 3Health News:John Schaeffler Appointed Senior Vice President for Federal Legislative Affairs 2Health News:Best Practice Database Adds Research Highlighting Effective Data Gathering Approaches for Competitive Intelligence and Successful Activities for Gaining Maximum Payer Access and Insights 2Health News:NASA's 'COLBERT' Supplied by Wyle is Designed to Minimize House Calls 2Health News:New technique that scrambles light may lead to sharper images, wider views 2Health News:New technique that scrambles light may lead to sharper images, wider views 3Health News:New technique that scrambles light may lead to sharper images, wider views 4
The Needle Loading Shield protects the head and torso during the needle loading process. The slim design allows the technician to load needles with both hands while looking through the lead glass....
The vertical needle holder conveniently positions 20 needles vertically in numbered positions for easy loading....
... prostate seeding needles for use ... quality, disposable needles used to ... procedures. Each needle has an ... insertion, and an echogenic tip ...
MT-BT-5001-25 prostate seeding needle (set of 25 unloaded needles).,MT-BT-5001-P prostate seeding needle, pre-plugged and pre-sterilized, unloaded or for use with MEDTECs ASAP™ pre-load seeding...
Medicine Products: