Navigation Links
Study Shows Metabolic Strategy of Stressed Cell

Major St. Jude Study of Changes in Gene Activity and Metabolic Enzymes Show How Cells Respond to a Sudden Decrease in the Levels of Coenzyme A, a Key Player in the Daily Biochemical Routines that Support Life

MEMPHIS, Tenn., March 23, 2007 /PRNewswire/ -- Investigators at St. Jude Children's Research Hospital have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.

The results provide the most detailed look ever obtained of the complex metabolic changes in a cell triggered by a potentially fatal stress. CoA plays key roles in the cell's metabolism by participating in biochemical reactions in specific areas throughout the cell.

"The study provides the first detailed look at how the cell shifts genetic gears to respond to a significant change in its ability to carry on its daily metabolic chores," said Suzanne Jackowski, Ph.D., a member of the St. Jude Infectious Diseases department and the paper's senior author.

The St. Jude study is a significant contribution to the growing field of metabolomics -- the study of the molecules involved in metabolism, added Charles Rock, Ph.D., a member of the St. Jude Infectious Diseases department and co-author of the paper. Coupled with genetic studies of the cell, metabolomics is giving scientists a more detailed picture of how the body maintains its health in both normal environments and during times of stress, such as starvation or disease.

A report on this work appears in the March issue of "Chemistry and Biology."

The researchers studied the response to decreased CoA in a mouse model by blocking CoA production. Following the shutdown of CoA production, the cells quickly recycled CoA from other jobs so it could concentrate all its efforts on a single task: extracting life-supporting energy from nutrients in the mitocho ndria-the powerhouses of the cell.

"We identified the metabolic rearrangements the cell undergoes to ensure that the liver keeps CoA levels high enough to produce glucose and the cells of the body maintain enough free CoA for the mitochondria to keep producing ATP," said Yong-Mei Zhang, Ph.D., of the St. Jude Infectious Diseases department and first author of the report.

Other authors of this paper include Shigeru Chohnan (St. Jude), Kristopher G. Virga and Richard E. Lee (University of Tennessee Health Science Center, Memphis, Tenn.); Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, James R. Bain and Christopher B. Newgard (Duke University Medical Center, Durham, N.C.).

This work was supported in part by the National Institutes of Health, a Cancer Center (CORE) Grant and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.

CONTACT: Public relations, Carrie Strehlau, +1-901-495-2295 or, Summer Freeman, +1-901-495-3061 or, Scientific Communications, Marc Kusinitz, Ph.D.,+1-901-495-5020 or , all of St. Jude Children'sResearch Hospital carrie.strehlau@stjude.org summer.freeman@stjude.org marc.kusinitz@stjude.org

Web site: http://www.stjude.org/

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


'"/>




Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... Inivata, a global clinical ... tumour DNA (ctDNA) analysis to improve personalised healthcare ... Clive Morris as Chief Medical Officer. ... development programme, scientific collaborations, and through to commercialisation ... in clinical outcomes for patients. Clive ...
(Date:5/24/2016)... Cirujanos holandeses han puesto en marcha una ... compartir sus mejores prácticas por el mundo y tratar ... Europa, África, Asia y Estados ... combina la transmisión en vivo con mensajería instantánea y ... "Imagine un médico de Medicines sans Frontieres ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
Breaking Medicine Technology:
(Date:5/25/2016)... ... 2016 , ... Dr. Travis Schwarz is an experienced dentist who leads ... 63366. He serves patients of all ages with a full menu of dental services, ... reflected in the superior patient reviews that he has consistently earned during his practice ...
(Date:5/25/2016)... NY (PRWEB) , ... May 25, 2016 , ... Today ... the launch of 11 innovative workshops and training opportunities in the growing ... the unique needs of individuals who are dealing with specific health issues—including injuries, illnesses, ...
(Date:5/25/2016)... ... May 25, 2016 , ... Cheryl Bowker of Bowker Insurance Group ... Dick McKenna Good Hands Legacy Award. McKenna ran one of Allstate’s most successful agencies ... inspire all those who knew him. The award named for him is not given ...
(Date:5/25/2016)... FL (PRWEB) , ... May 25, 2016 , ... The ... dive into the unique integrative medical wellness offerings of Europe, a continent that pioneered ... Tyrol, Austria will hear from numerous pioneers in medical wellness, including Henri Chenot, Founder ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... supporting the real time adjudication of medical service claims by Pharmacy Benefit Managers ... current medical claims management software. The TransactRx Cross Benefit Clearinghouse receives standard professional ...
Breaking Medicine News(10 mins):