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Study Shows Metabolic Strategy of Stressed Cell

Major St. Jude Study of Changes in Gene Activity and Metabolic Enzymes Show How Cells Respond to a Sudden Decrease in the Levels of Coenzyme A, a Key Player in the Daily Biochemical Routines that Support Life

MEMPHIS, Tenn., March 23, 2007 /PRNewswire/ -- Investigators at St. Jude Children's Research Hospital have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.

The results provide the most detailed look ever obtained of the complex metabolic changes in a cell triggered by a potentially fatal stress. CoA plays key roles in the cell's metabolism by participating in biochemical reactions in specific areas throughout the cell.

"The study provides the first detailed look at how the cell shifts genetic gears to respond to a significant change in its ability to carry on its daily metabolic chores," said Suzanne Jackowski, Ph.D., a member of the St. Jude Infectious Diseases department and the paper's senior author.

The St. Jude study is a significant contribution to the growing field of metabolomics -- the study of the molecules involved in metabolism, added Charles Rock, Ph.D., a member of the St. Jude Infectious Diseases department and co-author of the paper. Coupled with genetic studies of the cell, metabolomics is giving scientists a more detailed picture of how the body maintains its health in both normal environments and during times of stress, such as starvation or disease.

A report on this work appears in the March issue of "Chemistry and Biology."

The researchers studied the response to decreased CoA in a mouse model by blocking CoA production. Following the shutdown of CoA production, the cells quickly recycled CoA from other jobs so it could concentrate all its efforts on a single task: extracting life-supporting energy from nutrients in the mitocho
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