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Study Presented at ACC Shows Treatment With ISIS 301012 Added to,Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C,Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C,Levels of Less Than 70 mg/dL

as 30 days post last dose, Day 59 Table 2: ISIS 301012 Coadministered with Statins, Absolute ApoB and LDL-C Reductions. Absolute levels of ApoB and LDL-C in mg/dL at baseline and primary endpoint*. Placebo 30 mg/ 100 mg/ 200 mg/ 300 mg/ 400 mg/ wk wk wk wk wk ApoB Baseline 105 95 106 103 133 108 Primary Endpoint* 105 98 82 73 61 55 LDL-C Baseline 131 107 134 128 168 134 Primary Endpoint* 130 114 96 87 76 67 *Primary endpoint analysis was 30 days post last dose, Day 59 Table 3: ISIS 301012 Coadministered with Statins, Patients at Target. Number of patients (%) in each cohort at target lipid levels at the primary endpoint*. Parameter Target* Placebo 30 mg/ 100 mg/ 200 mg/ 300 mg/ 400 mg/ wk wk wk wk wk # of patients 13 8 8 16 8 8 LDL-C < 100 mg/dL 3 2 3 9 7 6 (23%) (25%) (38%) (56%) (88%) (75%) < 70 mg/dL 0 0 0 3 3 4 (19%) (38%) (50%) Non- HDL-C < 130 mg/dL 4 5 5 11 7 6 (31%) (63%) (63%) (69%) (88%) (75%) ApoB < 90 mg/dL 3 2 4 10 7 6 (23%) (25%) (50%) (63%) (88%) (75%) ALL LDL-C < 100 TARGETS Non-HDL- C < 130 2 2 3 8 7 6 ApoB<90 (15%) (25%) (38%) (50%) (88%) (75%) *Primary endpoint analysis was 30
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