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Study Presented at ACC Shows Treatment With ISIS 301012 Added to,Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C,Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C,Levels of Less Than 70 mg/dL

g/week) and LDL-C (67 mg/dL at 400 mg/week versus 76 mg/dL at 300 mg/week) than the 300 mg/week cohort.

    Table 1:  ISIS 301012 Coadministered with Statins, Summary of Results.

    Median % changes from baseline at primary endpoint*

    Per Protocol            Placebo    30 mg/week      100 mg/week

    # of patients            13        8                 8

    ApoB                     -1%       0% (p=0.80)     -20% (p=0.03)

    LDL-C                    -4%       4% (p=0.31)     -22% (p=0.01)

    VLDL-C                    7%       8% (p=0.84)      10% (p=0.66)

    Non-HDL-C                -1%       8% (p=0.44)     -20% (p=0.02)

    HDL-C                     9%       1% (p=0.24)      -4% (p=0.15)

    ApoA-1                    0%       0% (p=0.59)      -6% (p=0.66)

    TC                        2%       5% (p=0.72)     -15% (p=0.005)

    TG                        0%       4% (p=0.60)       4% (p=0.52)

    ApoB:ApoA-1              -1%       0% (p=0.97)     -15% (p=0.01)

    TC:HDL-C                 -6%       0% (p=0.27)     -15% (p=0.36)

    Per Protocol      200 mg/week     300 mg/week        400 mg/week

    # of patients    16               8                    8

    ApoB            -24% (p=0.004)  -52% (p < 0.0001)    -51% (p=0.0004)

    LDL-C           -30% (p=0.002)  -51% (p < 0.0001)    -47% (p=0.008)

    VLDL-C          -25% (p=0.38)   -63% (p = 0.08)      -69% (p=0.02)

    Non-HDL-C       -22% (p=0.02)   -51% (p < 0.0001)    -49% (p=0.008)

    HDL-C             6% (p=0.23)     5% (p = 0.41)        6% (p=0.60)

    ApoA-1            1% (p=0.93)     2% (p = 0.67)       -6% (p=0.43)

    TC              -13% (p=0.009)  -42% (p < 0.0001)    -34% (p=0.0001)

    TG              -25% (p=0.38)   -41% (p = 0.04)      -35% (p=0.02)

    ApoB:ApoA-1     -28% (p=0.006)  -55% (p < 0.0001)    -45% (p=0.0008)

    TC:HDL-C        -14% (p=0.06)   -41% (p < 0.0001)    -38% (p=0.01)

    p value = vs. placebo

    *Primary endpoint analysis w

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