Navigation Links
Study Presented at ACC Shows Treatment With ISIS 301012 Added to,Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C,Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C,Levels of Less Than 70 mg/dL

* ISIS 301012 coadministered with statins for only five weeks at 400 mg/week lowered LDL-C 47% beyond the levels achieved with statins alone, with similarly favorable effects on other atherogenic lipids

NEW ORLEANS and CARLSBAD, Calif., March 26, 2007 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. announced new results from its Phase 2 clinical trial of ISIS 301012 coadministered with statins presented today at the of Cardiology Annual Scientific Session (ACC) in New Orleans. In the study, patients with high cholesterol were treated for five weeks with up to 400 mg/week of ISIS 301012 added to ongoing stable doses of statins. Data from this study for dose cohorts through 300 mg/week were previously reported. In the 400 mg/week cohort, ISIS 301012 was well tolerated, and patients dosed per protocol experienced statistically significant median improvements in apoB-100, LDL-cholesterol (LDL-C), and triglycerides (TG) of 51%, 47%, 35%, respectively. Later this year, Isis plans to begin a longer-duration Phase 2 study of ISIS 301012 added to statins in patients with routine high cholesterol to define maintenance doses of ISIS 301012 which are expected to be in the range of 100-200 mg/week.

In this study, at a dose 400 mg/week four of eight patients achieved LDL-C levels below 70 mg/dL and six of eight achieved LDL-C levels below 100 mg/dL. Similarly at a dose of 300 mg/week, three of eight patients achieved LDL-C levels below 70 mg/dL and seven of eight patients achieved LDL-C levels below 100 mg/dL. For High-Risk patients, the recommended target levels of LDL-C are 100 mg/dL, and for Very High-Risk patients a target of less than 70 mg/dL should be seriously considered (see Adult Treatment Panel III Recommendations below). Patients in this cohort had baseline LDL-C levels ranging from 109 - 162 mg/dL and had been on statins for a median duration of four years. These results were achieved with only five
'"/>




Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
Post Your Comments:
(Date:5/21/2015)... WASHINGTON , May 21, 2015 ... following statement regarding the Medicare Part D offsets ... Century Cures initiative: "If the 21st Century ... billions from America,s premier health program – Medicare ... it may yield down the road. ...
(Date:5/21/2015)... May 21, 2015 ... - Zwecks Leistungsvergleich zur Expertise und ... EG-Mitgliedstaaten verwiesen, in denen uneingeschränkt betriebsfähige ... Sie ein Aegate-Land: beispielsweise BELGIEN   ... Bekämpfung von Arzneimittelfälschungen (FMD) handelt es ...
(Date:5/21/2015)... In praising today,s unanimous passage of ... House Energy and Commerce Committee, the Senior Care ... the unique challenges facing long-term care (LTC) pharmacy ... exempting Part D beneficiaries in skilled nursing facilities ... "lock-in" provision. The SCPC has made the case ...
Breaking Medicine Technology:EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 2EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 3SCPC Applauds Unanimous House Panel Passage of 21st Century Cures Bill Recognizing Unique Challenges Facing Long Term Care (LTC) Pharmacy Patients, Providers 2
... 2, 2007-The U.S. Food and Drug,Administration (FDA) today ... existing black box warning on,their products' labeling to ... behavior, known as suicidality, in young,adults ages 18 ... to two months). , The proposed labeling changes ...
... FDA notified,healthcare professionals of important new safety ... recent,clinical study in patients with limited-stage small ... phase,II clinical trial study combined chemotherapy and ... serious adverse events of TE,fistula (one fatal) ...
Cached Medicine Technology:FDA Proposes New Warnings About Suicidal Thinking, Behavior in,Young Adults Who Take Antidepressant Medications 2FDA Proposes New Warnings About Suicidal Thinking, Behavior in,Young Adults Who Take Antidepressant Medications 3
(Date:5/24/2015)... EnviroLeather™ by LDI, a leader in ... classic, rugged leather grain with enhanced stain resistance ... ink, to be easily removed. The collection is ... healthcare, hospitality and education environments. , InkGard Plus ... developing products that are more sustainable, less toxic ...
(Date:5/24/2015)... (PRWEB) May 24, 2015 Indiana Fiber ... provider announces Midwest Telecom of America, Inc. (MTA) has ... According to Cory Childs, IFN Enterprise Sales Manager, fiber ... providers. “IFN’s fiber transport provides MTA with the ... to their Tier 1 Internet and voice carriers located ...
(Date:5/24/2015)... (PRWEB) May 24, 2015 A ... indicator that the single best option for avoiding cardiovascular ... that fitness level was the single most powerful predictor ... variables such as diabetes and family history of premature ... maintaining lifelong heart and lung fitness. , The Importance ...
(Date:5/23/2015)... 2015 Dr. David Benvenuti, an experienced plastic ... a new article to his website that takes ... Benvenuti explained in the fascinating blog, he has recently ... earlobes. , Known as “gauging,” the technique involves placing larger ... Benvenuti said will eventually stretch the holes out to incredible ...
(Date:5/23/2015)... CO (PRWEB) May 23, 2015 On May ... in MuckFest. The event was a 5k mud obstacle run ... more than 2 million people worldwide, and the reason we ... community,” said Chad Davis, owner of Farrell’s eXtreme Bodyshaping. “One-hundred ... Multiple Sclerosis Society.” , The event was not only attended ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2
... WAYNE, Pa., Sept. 28 Escalon Medical Corp.,(Nasdaq: ... quarter and,twelve months ended June 30, 2007. For ... increased,to $38,837,780 compared with $29,790,698 in fiscal 2006. This ... million lump sum settlement payment,from IntraLase Corp. to the ...
... Sanarus Medical today announced a,partnership with leading ... These Centers, including breast care physicians from,Connecticut to ... the awareness and availability of an innovative, non-surgical,treatment ... as,fibroadenomas. Sanarus will host a gathering of these ...
... she is giving a,keynote address or visiting on the ... and possibility. "Only in America could someone like ... warm laugh, "I,m a physically disabled woman whose,father is ... temples,and I,m running for Town Council as a Republican." ...
... pressure to combat,childhood obesity, the market for licensed foods ... breaking the $1,billion mark in 2011, according to Kids, ... from market research publisher Packaged Facts. Between 2002 ... and,beverage products rose 9%, from $684 million to $746 ...
... A 6-month diet restored normal blood pressure, study finds , , ... identified overweight as a direct cause of high blood pressure. ... people can bring down blood pressure to healthy levels by ... achieved before the borderline to outright obesity is crossed, said ...
... Blue Cross Blue Shield of Michigan is,partnering with ... in,five Michigan cities to help enroll eligible uninsured children ... to urge community leaders and small,business owners to help ... Attendees will be asked to send their staffs to ...
Cached Medicine News:Health News:Escalon(R) Reports Financial Results for 2007 Fiscal Year 2Health News:Escalon(R) Reports Financial Results for 2007 Fiscal Year 3Health News:Escalon(R) Reports Financial Results for 2007 Fiscal Year 4Health News:Escalon(R) Reports Financial Results for 2007 Fiscal Year 5Health News:Escalon(R) Reports Financial Results for 2007 Fiscal Year 6Health News:Escalon(R) Reports Financial Results for 2007 Fiscal Year 7Health News:Sanarus Announces Partnership With Leading US Breast Care Physicians for the Next Generation Visica 2(TM) Treatment System for Fibroadenomas 2Health News:Humor and Hope Sustain NJ Woman Through Disabling Movement Disorder, Election Campaign 2Health News:Pressure to Promote Healthier Eating to Cause Minor Growing Pains for Kids' Licensed Foods and Beverages 2Health News:Weight Loss Can Control Hypertension 2Health News:Weight Loss Can Control Hypertension 3Health News:Blue Cross Blue Shield of Michigan Launches Effort in Five Michigan Cities with Department of Community Health to Enroll Uninsured Children in MIChild 2
... is engineered to distribute contact pressure evenly over ... back, to maximize stability and patient comfort. ... readily conformable to patient anatomy, to provide a ... wool liner is standard on both units, as ...
An indirect immunofluorescence antibody test for the qualitative and semi-quantitative detection of endomysial antibodies (EMA) in human serum as an aid in the diagnosis of celiac disease and dermati...
Optical Urethrotome for Telescope 2.7 mm for children....
ACMI urethrotomes are available in two distinct styles to meet your specific professional needs. The Classic Series™ Otis Urethrotome consists of a blade, straight tip, and ball tip, with an av...
Medicine Products: