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Studies Presented at Neurology Conference Highlight Early Efficacy,,Long-Term Tolerability, and High Patient Satisfaction with,Betaseron

he drug's approval in 1993. The long-term use of Betaseron was associated with a delay of clinically significant disability (e.g. time to use of a cane) and delayed onset of the secondary progressive phase of the disease. Results from the study also found that patients who started the pivotal trial with a lower EDSS score showed less accumulated disability at the long-term follow-up visit. This finding offers further support for the importance of early treatment with Betaseron. Use of Betaseron over 16 years revealed no new or unexpected adverse events.

The results of a third study, known as BRIGHT (Betaseron versus Rebif(R)* InvestigatinG Higher Tolerability),(5) showed that significantly more of the 306 Betaseron patients than the 148 Rebif patients were pain-free over 15 injections at three time points after injection (for example: at 30 minutes after injection, 42.6 percent versus 19.7 percent, respectively). Fewer patients treated with Betaseron versus Rebif reported injection-site reactions. Moreover, with autoinjectors being used by more than 92 percent of participants, there were significantly more pain-free patients in the Betaseron group versus Rebif at all time points (example: at 30 minutes after injection, 40.2 percent versus 16.2 percent, respectively). More patients treated with Betaseron compared to Rebif either had no pain or were satisfied with their treatment (76.9 percent versus 64.1 percent).

About Betaseron

Betaseron (Interferon beta-1b) is indicated for the treatment of relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations. Patients with multiple sclerosis in whom efficacy has been demonstrated include patients who have experienced a first clinical episode and have MRI features consistent with multiple sclerosis.

The most commonly reported adverse reactions are lymphopenia, injection- site reaction, asthenia, flu-like symptom complex, headache and pain. Gradual dose titration and us
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