Navigation Links
Stanford Researchers Find Brain Pathway of Depression in Rats

simultaneously--and very rapidly--to see the effect.

"What surprised me most was how specifically the measure tracked the depression-related behavior," said Airan. "We usually think of psychiatric disorders as fuzzy and intractable, and this study showed me that, with the right tools, we could really put psychiatry on a quantitative framework."

Leslie Meltzer, neurosciences graduate student and co-first author, searched for the cellular basis of these changes in circuitry. An obvious place to start, she said, was to look at the formation of new neurons in the hippocampus, a process that neuroscientists have suggested is at the root of how antidepressants work. What they found was that the growth of new neurons could account for the behavioral improvements seen from treatment as well as the circuitry changes. The converse was not true: Fewer new neurons in that region did not equal depression.

In other words, in their model system, the two states appear to funnel through a common pathway--despite very different cellular mechanisms.

"The holy grail of psychiatry is to try to find final common pathways that can make sense of how genes and life experiences end up with the same result," said Deisseroth. "And the same goes for medications. There are many treatments that act in fundamentally different ways--how do we make sense of all that complexity?"

Deisseroth predicted that, as noninvasive imaging of human brains gets better in the next few years, researchers will be able to measure these same quantitative measures in people as well. "That will be a wonderful thing when that happens," he said.

Others who contributed to this work are: Madhuri Roy, basic life sciences research associate; Yuqing Gong, a graduate student at the time in statistics and electrical engineering, and Han Chen, a graduate student in electrical engineering. This work was funded by the National Institutes of Health (including Deisseroth's Pioneer Award); NA
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Childrens Hospital and Stanford
2. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
3. Once-Fatal Metabolic Disorders Treatable, Says Stanford/Packard Researcher
4. Limiting Eligibility for Medical Studies Can Omit Women, African-Americans, Stanford Study Finds
5. Fragile X, Down Syndromes Linked to Faulty Brain Communication, Stanford Researcher Finds
6. Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity
7. Stanford Study Finds No Conclusive Benefit From Treating Kleptomania With Medication
8. Study of Drug Therapy for Compulsive Buying Yields a Puzzle, Stanford Researcher Says
9. NIEHS Researchers Identify Enzyme Critical in DNA Replication
10. Researchers Discover Method for Identifying How Cancer Evades the Immune System
11. Researchers Discover Gene For Rare Skin Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stanford Researchers Find Brain Pathway Depression Rats
(Date:9/30/2014)... Sept. 30, 2014  Based on its recent ... & Sullivan recognizes Ventana Medical Systems, Inc. (Ventana), ... 2014 North American Frost & Sullivan Award for ... along with a focus on innovation and improving ... in tissue-based cancer diagnostic solutions for patients worldwide. ...
(Date:9/30/2014)... September 30, 2014 The report ... Market Size, Share, Growth and Forecast, 2007 - 2017," ... worth USD 20.8 billion in 2012 and is further ... at a CAGR of 7.3% from 2012 to 2017. ... various health purposes, especially to prevent chronic diseases that ...
(Date:9/30/2014)... 30. September 2014 ... Acutus Medical, ... minimal-invasives 3D-Herzkammer-Bildgebungs- und Dipoldichte-Mappingsystem in Echtzeit ... zu komplexen Herzrhythmusstörungen einschließlich Vorhofflimmern führen ... einer zusätzlichen Finanzierung über 26,2 Mio. ...
Breaking Medicine Technology:Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 2Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 3Frost & Sullivan applauds the diversity of Ventana products and services for the cancer diagnostics market 4Nutraceutical Ingredient Market Will Reach USD 33.6 Billion Globally in 2018: Transparency Market Research 2Nutraceutical Ingredient Market Will Reach USD 33.6 Billion Globally in 2018: Transparency Market Research 3Nutraceutical Ingredient Market Will Reach USD 33.6 Billion Globally in 2018: Transparency Market Research 4Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 2Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 3
... to dramatically reduce the risk of cancer ... EAST HANOVER, N.J., April 12, 2007 /PRNewswire/ ... tablets to,patients receiving placebo in a major ... showed participants with Kit-positive,gastrointestinal stromal tumors treated ...
... 2007 - Immunicon,Corporation (NASDAQ-GM:IMMC) will exhibit at ... the Los Angeles,Convention Center, April 15 to ... the new CellCapture(TM) CTC,Mouse/Rat Kit and the ... Pharma Services offers assay development and clinical,trial ...
Cached Medicine Technology:Positive Results Prompt US National Cancer Institute to Make,Gleevec Available To Patients in Post-Surgical Gist Study 2Positive Results Prompt US National Cancer Institute to Make,Gleevec Available To Patients in Post-Surgical Gist Study 3Positive Results Prompt US National Cancer Institute to Make,Gleevec Available To Patients in Post-Surgical Gist Study 4Positive Results Prompt US National Cancer Institute to Make,Gleevec Available To Patients in Post-Surgical Gist Study 5Positive Results Prompt US National Cancer Institute to Make,Gleevec Available To Patients in Post-Surgical Gist Study 6Positive Results Prompt US National Cancer Institute to Make,Gleevec Available To Patients in Post-Surgical Gist Study 7Immunicon Will Exhibit CellCapture CTC Mouse/Rat Kit and EasyCount,System for Automated Cell Counting at AACR 2Immunicon Will Exhibit CellCapture CTC Mouse/Rat Kit and EasyCount,System for Automated Cell Counting at AACR 3Immunicon Will Exhibit CellCapture CTC Mouse/Rat Kit and EasyCount,System for Automated Cell Counting at AACR 4
(Date:9/30/2014)... 2014 Research by UC Irvine immunologists reveals new ... on a vital process that determines how the body,s ... version of Nature Immunology , neurology professor Dr. ... for Immunology colleagues describe a critical mechanism underlying how ... bloodstream. , A T cell is a type of ...
(Date:9/30/2014)... NV (PRWEB) September 30, 2014 EverStryke ... a free introduction to SurvivalLife.com along with a free book ... the attention of Shane Michaels, prompting an investigative review. ... well-known people in the survival and preparation niche, and this ... of the great classes and survival products that Joe offers ...
(Date:9/30/2014)... 30, 2014 VisitandCare.com reports ... has gone up more than 79 percent in 2014, ... company also reported total revenue tripled for its entirety ... company’s professional strategy has allowed them to partner with ... for patient comfort and privacy — with state-of-the-art surgical ...
(Date:9/30/2014)... Regenerative Medicine Solutions (RMS) is set ... Nashville, Tennessee. RMS welcomes the launch of an entirely ... of a new treatment center for the Lung Institute. ... Institute to Nashville, the hope is to bring awareness ... diagnosed and undiagnosed. With Nashville being a hub for ...
(Date:9/30/2014)... 30, 2014 Bifidobacteria, the primary bacteria ... poor diet, and stress, so a high Bifido probiotic ... of Ultimate Flora™ Men’s Complete contains 90 ... 7 Bifidobacteria strains to support a healthy large intestine ... up, and 32 billion cultures from 7 Lactobacillus strains ...
Breaking Medicine News(10 mins):Health News:UCI study uncovers important process for immune system development 2Health News:EverStryke: Review Exposes Joe Marshall’s Permanent Match Survival Product 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Regenerative Medicine Solutions Expanding 2Health News:ReNew Life Introduces Ultimate Flora™ Men’s Complete Probiotic 90 Billion—Comprehensive Probiotic Support Just for Men 2
... Institutes of Health in the United States has evaluated the ... and the average quantity of alcohol drunk per occasion and ... well as all cancers. The analysis is based on ... US, assessing more than 300,000 subjects who suffered over 8,000 ...
... age, forgetfulness and other signs of memory loss sometimes appear, ... that they may be experiencing early symptoms of Alzheimer,s disease ... 65 and older. But even when early memory problems ... variable. Some patients are at high risk while others are ...
... HealthDay Reporter , WEDNESDAY, Oct. 19 (HealthDay News) ... a lumpectomy have significantly fewer recurrences and, consequently, greater ... research says. The study also noted no ... as deaths from any cause were also reduced substantially. ...
... recent UT Southwestern Medical Center study found that estrogen regulates ... in specific parts of the brain may lead to obesity. ... Deborah Clegg, associate professor of internal medicine and senior author ... . "We hadn,t previously thought of sex hormones as being ...
... HealthDay Reporter , WEDNESDAY, Oct. 19 (HealthDay News) ... after birth interferes with development of the brain,s cerebellum, ... new research finds. For the study, researchers analyzed ... weeks, gestation) at two medical centers, the University of ...
... Department of Defense (DoD) Congressionally Directed Medical Research ... has awarded a $19.7 million grant to the ... consortium that will improve the quality of life ... combat. The Bridging Advanced Developments for ...
Cached Medicine News:Health News:Association of quantity of alcohol and frequency of consumption with cancer mortality 2Health News:Combination of available tests helps predict Alzheimer's disease risk 2Health News:Breast Radiation After Lumpectomy Saves Lives: Study 2Health News:UT Southwestern study shows estrogen works in the brain to keep weight in check 2Health News:Steroids Given to Preemies May Harm Brain Growth: Study 2Health News:Steroids Given to Preemies May Harm Brain Growth: Study 3Health News:University of Delaware to lead DoD orthopaedic rehabilitation consortium 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: