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Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension

essure alone and in combination with an ACE-I[5][6]. Further details about this proof-of-concept Phase II trial will be announced later in 2007 when it commences. The trial will be carried out in Europe with results due in the second half of 2008.

Speedel's next generation renin inhibitors include other compounds in the SPP600 series, the SPP1100 series with SPP1148 due to report first Phase I results in Q42007, and the SPP800 series currently in late-stage pre-clinical profiling. Each series is a different chemical class with distinct properties and is protected by different patent applications.


About SPP600 series
SPP635 is the most advanced compound of the SPP600 series of renin inhibitors being developed by Speedel. The company has made significant progress in the optimisation and development of this series of newly synthesised compounds by using rational drug design, including computer assisted molecular modelling techniques, state-of-the art preclinical disease models and human microdosing.

In December 2001, Speedel acquired a worldwide exclusive license from Roche covering its entire programme in renin inhibition. This license allows Speedel to use the acquired know-how for lead optimisation of its own compounds designated as the SPP600 series. Speedel holds full development and commercialization rights for these product candidates under the license agreement with Roche. If Speedel decides to offer rights to any Speedel compound from the series to a third party, Roche has a right of first negotiation with respect to such rights. If Roche has not expressed its interest in acquiring such rights within a defined period of time, or the parties have not reached an agreement on the terms of such rights, Speedel is free to grant such rights to any third party.

About Hypertension
Hypertension is a common disorder in which blood pressure is abnormally high, placing undue stress on the heart, b
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