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Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension

smn;9.0 to 153.2±8.9 mmHg; baseline vs. end of treatment). Diastolic blood pressure was also significantly reduced by 9.8 mmHg from 91.3±7.8 to 81.5±8.2 mmHg (p<0.001) in the SPP635 treated group compared to the placebo treatment (95.3±5.1 to 93.3±5.4 mmHg). These blood pressure measurements were taken at trough, 24 hours after the previous medication. Similar results were observed for ambulatory blood pressures, which were reduced both during the day as well as in the night.

The half-life of SPP635 had been previously reported to be approximately 24 hours suggesting once daily administration; these latest ambulatory blood pressure data confirm the use as of SPP635 as an once-a-day drug. The extent of blood pressure reduction is similar to those reported for the renin inhibitor SPP100 (aliskiren,Tekturna/Rasilez)[4].

Hans R. Brunner, Professor Emeritus of Medicine at the University of Lausanne, and acting Speedel Medical Director, commented: "These positive results show that SPP635 has comparable efficacy to other blood pressure lowering therapies. It will be exciting to see the first follow-on renin inhibitor to SPP100 demonstrate its potential in diabetic patients in further clinical trials."

Alice Huxley, CEO of Speedel, commented: "This success with SPP635 reinforces Speedel's strategy of building a family of renin inhibitors which can be profiled for both general and special patient populations. We continue to leverage our exceptional knowledge in renin inhibition which we believe has the potential to be the next gold standard for the treatment of different cardiovascular diseases."

Continued Phase II development
Clinical profiling of SPP635 will continue this year in special populations with a further study planned in diabetic patients with mild-to-moderate hypertension. This harder to manage patient group has been shown to respond to SPP100 to controlling blood pr
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