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Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting

ygenation, which may be exploited to increase the effectiveness of radiotherapy. The study was conducted to determine whether administration of SPI (IRL)-1620 prior to radiation enhances the efficacy of radiotherapy.

SPI (IRL)-1620 was administered in doses ranging from 1 to 9 nmol/kg via tail vein 15 minutes prior to radiation administration. Tumor diameter was measured twice a week for a total of 70 days.

Results

Control animals showed a progressive increase in tumor volume and all animals died by 53 days after tumor induction. As expected, no significant response to SPI (IRL)-1620 or to radiation therapy alone was seen. Animals treated with SPI-1620 followed by radiation experienced significantly reduced tumor volume and there was a significant increase in life span. This effect was dose proportional, with best effect seen at the higher dose.

Conclusion

Researchers concluded that SPI (IRL)-1620 significantly enhanced the efficacy of radiation treatment in mice.

Abstract #4058 -- ETB Receptor Agonist, SPI (IRL)-1620, Enhances the Efficacy of Cyclophosphamide and Cisplatin in Ovarian Tumor Bearing Mice

Ovarian cancer represents the most malignant carcinoma of the female genital tract and is often diagnosed only after the disease has reached the advanced stage. Currently, primary therapy includes surgery followed by chemotherapy. In preclinical studies, SPI (IRL)-1620 has demonstrated an enhanced efficacy of anti-neoplastic agents in breast and prostate tumor bearing rats. The present study was conducted to evaluate the effect of SPI (IRL)-1620 on the efficacy of cyclophosphamide and cisplatin in ovarian tumor bearing athymic (nu+/nu+) mice.

Results

Tumor volume of saline or SPI (IRL)-1620 alone treated mice increased at a similar rate, while cyclophosphamide and cisplatin produced reduction in tumor volume. However, SPI (IRL)-1620 administration prior to cyclophosphamide and cisplatin significantly enha
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