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Spectrum Pharmaceuticals Announces Data From Three Oncology,Programs Presented at the American Association of Cancer Research,Annual Meeting

zing an extremely sensitive assay method.

Conclusions

It was concluded that a single, intravesical dose of EOquin was well tolerated, and was not systemically absorbed when administered to patients immediately following TUR-BT for noninvasive bladder cancer. Based on the results of this Phase 2b study as well as a previously conducted Phase 1 study, a larger, Phase 3 trial of EOquin in non-invasive bladder cancer is being initiated.

Abstract #5434 -- Synergistic Interaction between the Oral Platinum Analog Satraplatin and Erlotinib

In preclinical studies, satraplatin was active in a number of various tumor models and in cells resistant to cisplatin, carboplatin and oxaliplatin. Erlotinib (Tarceva(R)) is a potent inhibitor of the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Since upregulation of the Erk and p38 pathways, which are downstream of EGFR, may play a role in the resistance to platinum analogs, the evaluation of whether inhibition of this pathway by erlotinib would enhance the sensitivity of non-small cell lung (A549, SW1573), colon (Lovo, WiDr) and ovarian (A2780, 2008) cancer cell lines to satraplatin was examined.

Conclusion

Satraplatin is synergistic with erlotinib, which may be related to changes in signaling, especially the p-Erk pathway. A randomized Phase 2 trial is currently investigating the clinical benefit of satraplatin and erlotinib, administered in a sequential schedule, for elderly patients with advanced non- small cell lung cancer (NSCLC).

Abstract #3118 -- SPI (IRL) -1620 Increases the Efficacy of Radiation Treatment in Mice Bearing Lymphoma Cell Induced Tumors

SPI (IRL)-1620 is a selective ETB receptor agonist that has been demonstrated in preclinical studies to selectively enhance tumor blood flow and potentiate the efficacy of chemotherapeutics in various tumor models. Improved transient blood flow to the tumor is associated with a net increase in tumor ox
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