Navigation Links
Six-Week Investigational Study In Adults With Major Depressive,Disorder Evaluates The Effectiveness of Adjunctive Aripiprazole,Therapy With Antidepressants

the six-week randomized treatment phase during which they continued their ADT plus double-blind adjunctive placebo or adjunctive aripiprazole (2-20 mg/day).

The primary efficacy endpoint was the mean change from baseline - the end of the prospective treatment phase - to the end of the randomized treatment phase in a standard measure called the MADRS Total Score, which can range from 0 (no symptoms) to 60 points (most severe symptoms). A reduction in MADRS Total Score represents improvement in depressive symptoms. Some of the secondary endpoints included Sheehan Disability Scale (SDS), MADRS-measured remission and response rates and Clinical Global Impression-Severity of Illness (CGI-S) score.

For the primary endpoint, the study showed that adults taking adjunctive aripiprazole had a greater reduction in MADRS Total Score from baseline compared to placebo (-8.8 vs. -5.8 points, p-value less than 0.001).

The discontinuation rate due to an adverse event for adults taking add-on aripiprazole was 3.3 percent and 2.3 percent for placebo. The most common adverse events in the add-on aripiprazole and add-on placebo groups, respectively, (greater than or equal to 5 percent and at least twice the incidence of placebo) were akathisia (23.1 percent vs. 4.5 percent), insomnia (7.7 percent vs. 2.3 percent), restlessness (14.3 percent vs. 3.4 percent), upper respiratory tract infection (8.2 percent vs. 4 percent), and blurred vision (6.6 percent vs. 1.7 percent).

About Major Depressive Disorder

Major depressive disorder (MDD) is characterized by one or more major depressive episodes, (i.e., at least two weeks of depressed mood or loss of interest accompanied by at least four additional symptoms of depression.) (2) It affects 6.7 percent of American adults (approximately 15 million individuals) in a given year(3) and is the most common mental health disorder after anxiety.(4)

About Aripiprazole

Aripiprazole is indicated for the treat
'"/>




Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
3. Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes
4. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
5. Mercks Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study
6. Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
7. Investigational Drug Cediranib (AZD2171) Shows Promise in Patients With Recurrent Glioblastoma (GBM)
8. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
9. Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting
10. Investigational Cancer Drug Pertuzumab Shows Promising Results in Advanced Breast Cancer When Combined with Herceptin
11. Shire Announces Positive Results of Studies With Guanfacine Extended Release, An Investigational Nonstimulant Medication Filed for the Treatment of ADHD in Children and Adolescents
Post Your Comments:
(Date:7/14/2014)... LONDON , July 14, 2014  VirtualScopics, Inc. ... IXI) jointly announced today the formation of a Scientific ... Edward Ashton , Ph.D., chief scientific officer, VirtualScopics, will ... "The formation of this joint Scientific Advisory ... and operational alliance we signed with IXICO plc on ...
(Date:7/13/2014)... 2014 Auf seiner ... veranstalteten F&E-Tagung meldete Astellas Fortschritte ... seines Forschungsrahmenprogramms. Die Tagung bot Astellas die ... klinischen Programme und die Konzernstrategie des Unternehmens ... darin, aktuelle Meldungen zu den Astellas-Initiativen in ...
(Date:7/13/2014)... , July 13, 2014  Eli Lilly ... announced results from its non-clinical study in genetically ... version of the beta-amyloid antibody N3pG and beta-secretase ... therapy was more effective in removing clumps of ... that is thought to lead to Alzheimer,s disease ...
Breaking Medicine Technology:VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 2VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 3VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 4VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 5VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 6VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 7VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 8VirtualScopics, Inc. And IXICO plc Announce The Formation Of A Scientific Advisory Board To Benefit Both Companies; Dr. Edward Ashton, Ph.D. Appointed Chairman 9Astellas erörtert Pipeline-Fortschritte auf F&E-Tagung 2Astellas erörtert Pipeline-Fortschritte auf F&E-Tagung 3Astellas erörtert Pipeline-Fortschritte auf F&E-Tagung 4New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 2New Data Shows Combination Therapy is More Effective than Monotherapy in Removing Beta-Amyloid Plaques from the Brains of Mice 3
... Roche NimbleGen (SIX: RO, ROG; Pink Sheets: RHHBY ... genomic services provider Ambry Genetics has officially become a ... EZ Exome workflow. They will provide target-enrichment services ... sequencing services for genetic research. Ambry Genetics has passed ...
... Luminex Corporation (Nasdaq: LMNX ) today announced ... Conference to be held September 20 - 22, 2010, ...   http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) (Logo:   http://www.newscom.com/cgi-bin/prnh/20100104/LUMINEXLOGO ) ... president and chief executive officer, will begin at 8:00 ...
Cached Medicine Technology:Ambry Genetics Becomes First Certified Service Provider in US for NimbleGen SeqCap EZ Exome 2Ambry Genetics Becomes First Certified Service Provider in US for NimbleGen SeqCap EZ Exome 3Luminex Corporation to Present at UBS Global Life Sciences Conference 2
(Date:7/14/2014)... AttorneyOne.com, a recognized authority on law, update ... the FDA on Hospira Lactated Ringer’s and 5% ... 11, that one lot of Lactated Ringers and 5% ... Inc., is recalled due to mold contamination. The specific ... of fluid and electrolytes, with or without minimal carbohydrate ...
(Date:7/14/2014)... EurekaMag.com has newly published results of 64,900 ... disease that ranges in severity from a mild ... illness that attacks the liver. An estimated 3.2 million ... virus infection of which approximately 80% of people develop ... all studies on Hepatitis C , the Life, Earth ...
(Date:7/14/2014)... Wa (PRWEB) July 14, 2014 According to ... this is a helpful guide that features a series of ... exposes in its review that this book can help readers ... causes of high blood pressure, and effective methods to ... they are reviewed now by Vkool, was penned by Ken ...
(Date:7/14/2014)... Seattle, Wa (PRWEB) July 14, 2014 ... And Violet Protocol book review recently updated ... that consists of a wide range of ... symptoms of endometriosis including:, ...     Avoiding meat and dairy products , ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 According to the Boost ... helpful book for women who want to learn how to increase ... This book consists of 7 chapters including:, , ... Grow? , Chapter 2 – How Natural Breast Enlargement ... Your Breasts Look Bigger , Chapter 4 – The ...
Breaking Medicine News(10 mins):Health News:Hospira Lactated Ringer’s and 5% Dextrose Injection Recalled: AttorneyOne Monitor and Keep Consumers Informed 2Health News:Hospira Lactated Ringer’s and 5% Dextrose Injection Recalled: AttorneyOne Monitor and Keep Consumers Informed 3Health News:EurekaMag.com Publishes 64,900 New Studies on Hepatitis C 2Health News:Blood Pressure Solution Book Review Exposes Ken Burge's Hypertension Treatment Guide – Vkool.com 2Health News:Blood Pressure Solution Book Review Exposes Ken Burge's Hypertension Treatment Guide – Vkool.com 3Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 3Health News:Boost Your Bust Book Review Exposes Jenny Bolton's Breast Enhancement Guide – Vkool.com 2Health News:Boost Your Bust Book Review Exposes Jenny Bolton's Breast Enhancement Guide – Vkool.com 3
... (IANS) While the Nepalese government's attention is focused on ... among migrant labourers, intravenous drug users and sex ... groups in the country with the rate of infection ... to Nepal's National Centre for AIDS and STD (sexually ...
... of dengue cases in affluent Singapore has surpassed an epidemic ... . ,The National Environment Agency (NEA) and ... that the weekly number of dengue cases reported last week ... week. This number breached the "epidemic threshold" of 378 cases ...
... exposed themselves outside the Supreme Court on Tuesday in ... legal challenge against advertising restrictions . ,The ... had all raised healthy children on natural breast milk. ... their breasts. ,"Infant formula is dangerous," ...
... John Travolta has blamed psychotropic drugs for the Virginia Tech and ... at the whole story , it has not so much to ... that if you analyze most of the school shootings, it is ... it," New York Post quoted Travolta, as saying. ,The ...
... increasingly monitoring what their kids watch on TV or the ... national survey of 1,008 parents of children ages 2-17, a ... their children's media use, while only 18 percent say that ... concerned about a lot of what they see in the ...
... heat content on interannual-to-decadal time scales much more ... an Indian scientist has revealed. ,Krishna ... Model Diagnosis and Intercomparison (PCMDI), and now at ... find the apparent discrepancies between modelled and observed ...
Cached Medicine News:Health News:Huge Rise in AIDS Cases Among Nepal Housewives 2Health News:Filipino Mothers Go Bare Protesting Against Milk Formula Companies 2Health News:Parents are More Concerned on What Their Kids Watch 2Health News:IIT Delhi Scientist Finds Climate Models Consistent With Ocean Warming Observations 2
... Easy Breeze Air Gel Dryer : Dry up ... 24 gels 8 10 cm without a ... rapid drying, or no heat for controlled drying ... transparent, dried gels. Add and remove gels at ...
Each GelAir™ system drying frame includes two main components, a plastic drying outer frame and a metal square inner frame, as well as 8 clamps per frame. Supplied as a set of two frames....
... Breeze Air Gel Dryer : Dry up to ... gels 8 10 cm without a vacuum ... drying, or no heat for controlled drying of ... dried gels. Add and remove gels at any ...
... SGD5040 Slab Gel Dryer incorporates sturdy metal housing and ... The large surface area makes it perfect for drying ... Slim Profile 40cm x 50cm (W x D) ... Rates allows you to optimize your heating ...
Medicine Products: