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Sirion Therapeutics Announces Clinical Data to be Presented at the,2007 Association for Research in Vision and Ophthalmology (ARVO),Annual Meeting

TAMPA, Fla., April 23, 2007 /PRNewswire/ -- Sirion Therapeutics announced today that data on two of the Company's pipeline compounds, ST-601 (difluprednate) and ST-602 (fenretinide), will be presented at the 2007 annual meeting of The Association for Research in Vision and Ophthalmology (ARVO) in Ft. Lauderdale, FL. In addition to these presentations, the company will be hosting a reception for ARVO attendees.

ST-601 (difluprednate) is currently being evaluated in two phase III clinical trials in the treatment of ocular inflammation following cataract surgery. ST-601 (difluprednate) was acquired by Sirion last year through an exclusive licensing agreement with Senju Pharmaceutical Co., LTD of Japan. The agreement gives Sirion the U.S. rights to develop and market a topical ophthalmic emulsion containing the steroid compound difluprednate for the treatment of inflammatory eye diseases and conditions.

ST-602 (fenretinide) is currently being evaluated in a phase II clinical trial in the treatment of Geographic Atrophy (GA) in patients with age-related macular degeneration. The trial is a multicenter, randomized, double-masked, placebo controlled, dose-comparison in up to 225 patients in approximately 20 sites in the United States.

"We are pleased to announce the upcoming schedule of presentations relating to difluprednate and fenretinide at the ARVO annual conference. ARVO is the one of the oldest, largest and most highly respected vision research organizations in the world," stated Barry Butler, President and Chief Executive Officer of Sirion Therapeutics. "This is exciting news for our company in that it is the first time we will be presenting scientific data on our pipeline compounds. These presentations will provide support of the potential future clinical utility of these compounds in the treatment of ophthalmic eye diseases and conditions and demonstrate our commitment to discovering, de veloping and commercializing ophthalmic therapies for unmet needs."

    Sirion Therapeutics Reception for all ARVO attendees:


    A company update and presentation by Sirion Therapeutics' senior

    executives

    Date: Tuesday, May 8, 2007, 7:30 p.m. -- 9:00 p.m.

    Venue: Ft. Lauderdale Grande

    For additional information, contact Mary Leaper at

     or register online at

    www.siriontherapeutics.com/ARVO and use the password VISION.



    ARVO poster presentations featuring ST-601 (difluprednate):


    Preclinical Pharmacokinetics of Difluprednate Emulsion

    Session Date: Tuesday, May 8, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B741, Program Number: 2651


    Ocular Distribution and Metabolism after Instillation of Difluprednate

     Ophthalmic Emulsion in Rabbits

    Session Date: Tuesday, May 8, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B744, Program Number: 2654


    Preclinical Toxicity of Difluprednate Emulsion

    Session Date: Tuesday, May 8, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B743, Program Number: 2653


    Efficacy of Difluprednate Ophthalmic Emulsion in Preclinical Studies of

     Uveitis

    Session Date: Tuesday, May 8, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B742, Program Number: 2652


    Difluprednate Emulsion Inhibits Postoperative Inflammation in Rabbit

     Paracentesis Model

    Session Date: Tuesday, May 8, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B745, Program Number: 2655


    A Phase III, Non-Inferiority Study of Difluprednate Ophthalmic Emulsion

     (DFBA), 0.05% in the Treatment of Anterior Uveitis

    Session Date: Wednesday, May 9, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B808, Program Number: 3904


    A Phase III, Open-Label, Clinical Study of Difluprednate Ophthalmic

     Emulsion (DFBA), 0.05% in the Treatment of Severe Refractory Anteri
or

     Uveitis

    Session Date: Wednesday, May 9, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B809, Program Number: 3905


    Efficacy and Safety Results of a Phase III Study of Difluprednate

     Ophthalmic Emulsion 0.05% in Postoperative Inflammation

    Session Date: Wednesday, May 9, 2007, 8:30 a.m. - 10:15 a.m.

    Posterboard Number: B807 , Program Number: 3903


    ARVO poster presentations featuring ST-602 (fenretinide):


    Reduction of Serum Retinol Binding Protein Arrests the Accumulation of

     Toxic Retinal Fluorophores: A Nonpharmacological Approach

    Session Date: Tuesday, May 8, 2007, 3:00 p.m. - 4:45 p.m.

    Posterboard Number: B220, Program Number: 3244


    Megalin and Related Endocytic Receptors Mediate Uptake of Retinoid Binding

     Proteins in the Retinal Pigment Epithelium

    Session Date: Tuesday, May 8, 2007, 3:00 p.m. - 4:45 p.m.

    Posterboard Number: B221, Program Number: 3245

mleaper@siriontherapeutics.com

About Sirion Therapeutics, Inc.

Sirion Therapeutics is an ophthalmic biopharmaceutical company poised to compete in the $4 billion U.S. prescription ophthalmic market segment. Sirion is dedicated to the development and commercialization of innovative products to address unmet clinical needs. The company is currently developing a portfolio of product candidates that includes therapies in the areas of inflammatory diseases and conditions, allergy, dry eye, herpetic keratitis and dry age-related macular degeneration. Sirion is focused on growth through in- licensing, acquisition and geographic expansion. For more information regarding Sirion, please visit Sirion's website at http://www.siriontherapeutics.com.

CONTACT: Penny Cobb, of Sirion Therapeutics, Inc., +1-813-496-7325 x221, pcob b@siriontherapeutics.com

Web site: http://www.siriontherapeutics.com/http://www.siriontherapeutics.com/ARVO/

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