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Shire to Present New Scientific Data on ADHD Treatment Portfolio at,APA Annual Meeting

in Children Aged 6 to 12 Years With Attention-Deficit/Hyperactivity Disorder APA Poster# NR750 DAYTRANA (methylphenidate transdermal system): May 23, 2007; 12:00 p.m. PDT (3:00 p.m. EDT) Efficacy and Safety of MTS in Male and Female Pediatric Subjects with ADHD APA Poster# NR665 May 23, 2007; 12:00 p.m. PDT (3:00 p.m. EDT) 12-Month Efficacy and Tolerability of MTS in Children with ADHD APA Poster# NR664 ADDERALL XR (mixed salts of a single-entity amphetamine product): May 23, 2007; 12:00 p.m. PDT (3:00 p.m. EDT) Long-Term Cardiovascular Safety of Mixed Amphetamine Salts Extended Release in Adolescents with ADHD APA Poster# NR652 SPD465 (triple-bead mixed amphetamine salts): May 21, 2007; 11:00 a.m. PDT (2:00 p.m. EDT) Extended Duration of Action of SPD465, a 16-Hour Mixed Amphetamine Salts Formulation, in the Treatment of Adults with ADHD Oral Presentation SPD503 (guanfacine HCl extended release): May 23, 2007; 12:00 p.m. PDT (3:00 p.m. EDT) A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents with Attention- Deficit/Hyperactivity Disorder APA Poster# NR659 May 23, 2007; 12:00 p.m. PDT (3:00 p.m. EDT) Long-Term, Open-Label Study of Guanfacine Extended Release in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder APA Poster# NR658

About VYVANSE and ADDERALL XR

VYVANSE or ADDERALL XR should not be taken by patients who have advanced arteriosclerosis; symptomatic cardiovascular disease; moderate to severe hypertension; hyperthyroidism; known hypersensitivity or idiosyncrasy to sympathomimetic amines; agitated states; glaucoma; a history of drug abuse; or during or within 14 days after treatment with monoamine oxidase inhibitors (MAOIs).

Sudden death has been reported in association with CNS stimulant treatment
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1. Shire Announces Positive Results of Studies With Guanfacine Extended Release, An Investigational Nonstimulant Medication Filed for the Treatment of ADHD in Children and Adolescents
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