( needs todemonstrate at least six of ni...)Shire Announces Positive Results of Studies With Guanfacine,Extended Release, An Investigational Nonstimulant Medication Filed,for the Treatment of ADHD in Children and Adolescents,Health

needs to demonstrate at least six of nine symptoms of inattention; and/or at least six of nine symptoms of hyperactivity/impulsivity; the onset of which appears before age 7 years; that some impairment from the symptoms is present in two or more settings (e.g., at school and home); that the symptoms continue for at least six months; and that there is clinically significant impairment in social, academic or occupational functioning and the symptoms cannot be better explained by another psychiatric disorder.

Although there is no "cure" for ADHD, there are accepted treatments that specifically target its symptoms. The most common standard treatments include educational approaches, psychological or behavioral modification, and medication.

    For further information please contact:


    Porter Novelli for Shire


    Marion E. Glick

    212.601.8273

    917.301.4206 (on site at APA)


    Debra Gemme

    212.601.8342

    703.298.4030 (on site at APA)

All GXR Posters will be presented in Sails Pavilion, Upper Level in the San Diego Convention Center

APA Poster # NR659

Wednesday, May 23, 2007 at 12 p.m. PDT (3 p.m. EDT)

A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents with Attention- Deficit/Hyperactivity Disorder (Trial 301)

J. Biederman, M.D.; R. Melmed, M.D.; A. Patel, M.D.; K. McBurnett, M.D.; J. Donahue, M.P.H.; A. Lyne, M.S.C.

APA Poster # NR656

Wednesday, May 23, 2007 at 12 p.m. PDT (3 p.m. EDT)

Randomized, Double-Blind Study of Guanfacine Extended Release in Children Aged 6 to 17 Years With Attention-Deficit/Hyperactivity Disorder (Trial 304)

F. Sallee, M.D.; J. McGouth; T. Wigal, Ph.D.; J. Donahue, M.P.H.; A. Lyne, M.S.C.; J. Biederman, M.D.

APA Poster # NR658

Wednesday, May 23, 2007 at 12 p.m. PDT (3 p.m. EDT)

Long-Term, Open-Label Study of Guanfacine Extended Release in Children and Adolesce
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