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Seroquel Sustained Release Schizophrenia Data Presented at ECP,Congress in Madrid

LONDON, March 18, 2007-AstraZeneca today announced clinical trial data for Seroquel sustained release formulation (quetiapine fumarate sustained release), at the European Congress of Psychiatry (ECP) in Madrid. The data demonstrated that the SEROQUEL® sustained release formulation (quetiapine fumarate sustained release), administered once daily, significantly improved symptoms associated with schizophrenia (measured by PANSS) and increased the time to psychiatric relapse, when administered through a three-step dose initiation aimed at reaching the effective dose range on the second day of treatment.

SEROQUEL® sustained release formulation is currently under review by regulatory authorities around the world for the treatment of schizophrenia and has not been approved in any market.

A randomised, double-blind study of 588 patients with acute schizophrenia (Study 132) compared SEROQUEL® sustained release formulation (400 mg/day, 600 mg/day or 800 mg/day) with placebo and found a significant improvement in Positive and Negative Syndrome Scale (PANSS) total scores from baseline for all doses. After six weeks’ treatment, reductions of 24.8 (p=0.03), 30.9 (p<0.001), and 31.3 (p<0.001) points were seen with 400, 600, and 800 mg doses, respectively, compared with a reduction of 18.8 points for placebo. Patients on SEROQUEL® sustained release formulation also had significantly better scores on the Clinical Global Impression (CGI)-Severity scale and significantly more patients showed improvement on the CGI-Improvement scale compared to placebo.

A second randomised, double-blind placebo controlled study (Study 004) examined time to first psychiatric relapse in 197 patients with clinically stable schizophrenia treated with either SEROQUEL® sustained release formulation (mean dose 669 mg/day) or placebo. Patients treated with SEROQUEL® sustained release formulation ex
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