( patients who achieved overall clinical...)Separate Sets of Research Show Treatment Improved Quality of Life,,,in as Early as Three Weeks; Patient Adherence to Medication is,,,Multifactorial,Health

patients who achieved overall clinical improvement at six weeks (the primary endpoint of the study) experienced a significantly greater mean QoL increase compared to patients with no clinical improvement. The primary endpoint, overall clinical improvement, was defined as improvement from baseline at week 6 in Physician Global Assessment score accompanied by an improvement in at least one other clinical parameter (rectal bleeding, stool frequency, patient functional assessment, or sigmoidoscopy) and no worsening in any of the remaining clinical features.

"The ultimate goals of UC therapy are to treat active disease and prevent relapse, in order to improve patients' quality of life," said lead author E. Jan Irvine, M.D., Head, Division of Gastroenterology, St. Michael's Hospital, Toronto, Ontario and Professor of Medicine at the University of Toronto. "These data show that Asacol did, in fact, improve quality of life in mildly and moderately active UC patients, as early as three weeks after starting therapy."

Patient Compliance to 5-ASA Therapy is Multifactorial

The study, "Predictors of 5-ASA Prescription Persistence in Patients with Ulcerative Colitis," sought to identify factors for 5-ASA therapy non- adherence in patients with UC. Of the more than 3,000 UC patients with 5-ASA prescriptions in the database, 1,530 did not refill their prescription at three months. The study identified that the most significant factors in predicting patient non-adherence at three months were gender (men were less compliant than women), psychiatric history (patients with documented psychiatric illness were less compliant) and co-pay (higher co-payments deterred patients from refilling their prescriptions).

"This study not only reaffirms previous research showing that adherence to medication is a critical issue in the treatment of UC, but also demonstrates that the factors involved in patient
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