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Second Successful Quigley QR-443 Study Suggests Method of Action,Relevant to Broad Range of Chronic Inflammatory Diseases - Human,Study to Follow -

processes and pathways - a disruption of homeostasis.

Dr. Richard Rosenbloom EVP/COO Quigley Pharma, Inc. stated, "We are encouraged by these and previous results and are looking forward to subjecting the compound to more rigorous tests to support eventual commercialization."

About The Study

The study results demonstrated a correlation to the levels of serum IL-6 and the degree of cachexia. Mice responding to QR-443 treatment had much lower levels of serum IL-6 which correlated with reduced cachexia, compared to non responders and the control population who had elevated IL-6 and dramatic weight loss. These findings are in agreement with several previous studies demonstrating the increased presence of IL-6 in the etiology of cachexia and other diseases related to inflammation.

The purpose of the study was to replicate positive oral dose response trials in BALB/C mice as well as to investigate the possible relationship of the levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) cytokines which have been associated with the severity and progression of cachexia. In this experiment a larger group of mice was used, their weight being recorded and blood being drawn prior to the onset of cachexia and then at the peak of cachexia which marked the end of the experiment. There was no correlation between the levels of TNF-alpha and the severity of cachexia and levels of IFN-gamma were lower than the detectable assay level.

The Quigley Corporation makes no representation that the U.S. Food and Drug Administration or any other regulatory agency will allow the aforementioned Compound to be tested in humans or marketed. Furthermore, no claim is made that the potential medicine discussed here is safe, effective, or approved by the Food and Drug Administration.

About The Quigley Corporation

The Quigley Corporation is a diversified natural health medical science company. Its Cold Reme
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