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Second Successful Quigley QR-443 Study Suggests Method of Action,Relevant to Broad Range of Chronic Inflammatory Diseases - Human,Study to Follow -

DOYLESTOWN, Pa., June 20, 2007 /PRNewswire-FirstCall/ -- Quigley Pharma, www.QuigleyPharma.com, a wholly owned subsidiary of The Quigley Corporation announced today that it has completed a follow-up study to evaluate the impact of QR-443 on levels of a pro-inflammatory cytokine Interleukin-6 (IL-6) in a cachexia model. This new data concluded that responding mice had lower levels of serum IL-6 when administered QR-443 orally than mice that received placebo. This reduction in IL-6 suggests a method of action for the delayed onset and reduced severity of cachexia observed in this study as well as the previously conducted cachexia model study.

QR-443 was formulated with the intention to impact metabolic imbalances and chronic inflammation. Cachexia is an extremely debilitating and life threatening, wasting syndrome associated with chronic diseases such as cancer, AIDS, chronic renal failure, COPD and rheumatoid arthritis, where inflammation has a significant impact and patients experience loss of weight, muscle atrophy, fatigue, weakness and decreased appetite.

A reduction in IL-6 is associated with a reduction in inflammation and suggests that QR-443 may have a role in a broad range of chronic inflammatory diseases. The Company has begun developing a human study protocol to evaluate the safety and impact of this compound on specific metabolic processes altered by chronic inflammation and the presence of IL-6.

Chronic inflammation is also associated with other disorders such as rheumatoid arthritis, metabolic syndrome, COPD, AIDS and cancer and can cause physical, metabolic and physiological limitations. Interleukin-6 (IL-6) is a pro-inflammatory cytokine secreted to stimulate an immune response to trauma and disease leading to inflammation. Inflammation and the presence of IL-6 have been shown to negatively effect "normal" metabolic
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