Navigation Links
Second Phase III Study Evaluating Gilead's Viread for the Treatment,of Chronic Hepatitis B Virus Meets Primary Endpoint

FOSTER CITY, Calif.--(BUSINESS WIRE)--Jun 25, 2007 - Gilead Sciences, Inc. (Nasdaq:GILD) today announced that Study 103, a Phase III clinical trial evaluating the company's once-daily anti-HIV drug Viread(R) (tenofovir disoproxil fumarate or tenofovir DF) 300 mg as a potential treatment for chronic hepatitis B virus (HBV) infection, met its primary efficacy endpoint. The data show that Viread is non-inferior to the company's once-daily antiviral drug Hepsera(R) (adefovir dipivoxil) among patients with "e" antigen (HBeAg)-positive chronic hepatitis B. The primary efficacy endpoint, the proportion of patients with a complete response at week 48, was defined by serum HBV DNA levels below 400 copies/mL and histologic improvement characterized by at least a two point reduction in the Knodell necroinflammatory score (a measure of necro-inflammation - an inflammatory process in the liver including or leading to death of liver cells) with no concurrent worsening of fibrosis (scarring of liver tissue).

At 48 weeks, 66.5 percent of patients in the Viread arm (n=176) had a complete response compared to 12.2 percent in the Hepsera arm (n=90; p less than 0.001). The most commonly observed treatment-emergent adverse events of moderate intensity or higher were abdominal pain, back pain, headache, respiratory infections and transaminase elevations. The incidence of these events was comparable between the Viread and Hepsera arms of the study. In addition, the most frequently observed grade 3 or 4 laboratory abnormalities were elevations in transaminase and serum amylase and were comparable between the two arms. Full study results will be submitted for presentation at an upcoming scientific meeting.

Study 103 is the second of two Phase III pivotal studies evaluating the efficacy, safety and tolerability of Viread for the treatment of chronic hepatitis B to have met its primary efficacy endpoint. Earlier this month, the co
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
2. Second Phase III Study Evaluating Gileads Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint
3. Second Successful Quigley QR-443 Study Suggests Method of Action Relevant to Broad Range of Chronic Inflammatory Diseases - Human Study to Follow -
4. NeurogesX Announces Presentation of Positive Phase 3 Clinical Data at the Second International Congress on Neuropathic Pain Meeting (NeuPSIG)
5. Repros Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism
6. Pharmions Amrubicin Shows Encouraging Results Compared to Standard of Care in Second Line Treatment of Small Cell Lung Cancer
7. Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology
8. Kosan Presents Promising Phase 1 Data on Second-Generation Hsp90 Inhibitor, Alvespimycin, Showing Antitumor Activity in Refractory Breast and Ovarian Cancers at ASCO
9. Gilead Announces Achievement of Primary Efficacy Endpoint in Second Phase III Study of Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis
10. Amlodipine and Olmesartan Study Results Released;Late Breaker Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting (ASH 2007)
11. Amlodipine and Olmesartan Study Results Released; Late Breaker Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting (ASH 2007)
Post Your Comments:
(Date:8/28/2015)... N.C. , Aug. 28, 2015  Delays ... research projects can slow down the decision-making process, ... is, therefore, absolutely critical for biopharmaceutical companies to ... research approval process for quicker and more meaningful ... by Best Practices, LLC, nearly three-quarters of benchmarked ...
(Date:8/28/2015)... -- Research and Markets ( ... "Investigation Report on China,s Pranoprofen Market, 2010-2019" ... discovered by Welfide (Mitsubishi Tanabe Pharma Corporation formerly ... inflammatory drug, pranoprofen was later developed into eye ... trade name of pranopulin for the treatment of ...
(Date:8/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/jq34zf/investigation ) ... on China,s Tobramycin Market, 2010-2019" report to their ... eye drop and ointment are the most common prescription ... caused by eye infection. Currently, dozens of enterprises in ... tobramycin, among which the Top 5 are s.a. Alcon- ...
Breaking Medicine Technology:Expediting the Pharmaceutical Market Research Process for Faster Insights 2Investigation Report on China's Pranoprofen Market, 2010-2019 2Investigation Report on China's Tobramycin Market, 2015-2019 2
... NEW YORK, Sept. 5, 2011 Reportlinker.com announces ... in its catalogue: U.S. Market ... http://www.reportlinker.com/p0610531/US-Market-for-Emergency-Room-Equipment-2011.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging In 2010, the ... at over $960 million. The U.S. market for ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced ... Baird,s 2011 Health Care Conference Onyx ... September 7, 2011 at 11:30 a.m. Eastern Time (8:30 a.m. ... 2011 Subsequently, Onyx will present at the Stifel Nicolaus ...
Cached Medicine Technology:U.S. Market for Emergency Room Equipment 2011 2U.S. Market for Emergency Room Equipment 2011 3U.S. Market for Emergency Room Equipment 2011 4U.S. Market for Emergency Room Equipment 2011 5U.S. Market for Emergency Room Equipment 2011 6U.S. Market for Emergency Room Equipment 2011 7
(Date:8/31/2015)... SC (PRWEB) , ... August 31, 2015 , ... GenHart ... making it their business to help small businesses operate as efficiently and cost effectively ... They've already made an impact in their first year of operation – and the ...
(Date:8/30/2015)... ... August 31, 2015 , ... The acknowledgement from Caribbean Journal comes after ... in 2015. The island of Providenciales itself received a TripAdvisor Traveller's Choice Award ... Grace Bay is offering a special promotion for newlyweds and honeymooners to celebrate this ...
(Date:8/30/2015)... ... August 31, 2015 , ... This month, top ... to help assisted living facilities and nursing homes protect their residents from neglect ... to security experts at the company, security systems don’t just protect; they also ...
(Date:8/30/2015)... ... 30, 2015 , ... InHealth Media ( http://www.inhealthmedia.com ) announced ... Director for InHealth Media. Mr. Spector comes with a wide array of ... on-air television, producing shows, on air-radio and media relations. , Brian joins ...
(Date:8/30/2015)... ... August 30, 2015 , ... ... devices for the treatment of prostate cancer, has announced the roll-out of its ... the treatment center in Puerto Vallarta, Mexico. , The Sonablate® technology currently in ...
Breaking Medicine News(10 mins):Health News:GenHart Software, LCC Launches Scheduling, Appointment Reminder, Text Marketing Software Designed to Help Businesses Increase Revenue While Decreasing Client Attrition 2Health News:GenHart Software, LCC Launches Scheduling, Appointment Reminder, Text Marketing Software Designed to Help Businesses Increase Revenue While Decreasing Client Attrition 3Health News:Grace Bay Beach Named a Top Beach Destination for Weddings 2Health News:Total Security Announces Security Systems Tips for New York Assisted Living Facilities and Nursing Homes 2Health News:Total Security Announces Security Systems Tips for New York Assisted Living Facilities and Nursing Homes 3Health News:InHealth Media Appoints New Global Communications Director 2Health News:Image Fusion Technology Combines MRI and Ultrasound Images to Treat Prostate Cancer 2
... CHERRY HILL, N.J., Aug. 25 Nuvilex, Inc. (OTC Bulletin ... on September 1, 2009. Additionally, regional shareholder meetings will be held ... and Los Angeles on September 18th. Regional shareholder meeting times and ... , "We are very aware of our shareholders, ...
... , , , IRVINE, ... the inventor of Pulse CO-Oximetry(TM) and Measure-Through Motion and Low-Perfusion ... by U.S. News & World Report as one of ,America,s ... SET pulse oximetry technology. , , ...
... DALLAS Aug. 25, 2009 Minorities have poorer results ... used to remove plaque from inside the carotid artery, according ... author of the study in the journal Stroke. ... July issue of the journal, found that higher rates of ...
... T. Chu, MD, PhD, associate professor at the University ... professor, Massachusetts Institute of Technology, received the 2009 Julie ... The Ellison Medical Foundation, the grants provide funding of ... in advancing understanding of basic aging and its impact ...
... , , ... Iowa has agreed to pay the United States $4.5 million to resolve ... announced today. , , ... claims to Medicare by having financial relationships with five physicians that violated ...
... ... MyClyns Product, the New Personal Germ Protection Spray , ... Mount Kisco, NY (PRWEB) August 25, 2009 -- ... media agency specializing in national brand OTC health and beauty products, recently signed an ...
Cached Medicine News:Health News:Nuvilex to Issue Positive Shareholder Newsletter 2Health News:Nuvilex to Issue Positive Shareholder Newsletter 3Health News:Nuvilex to Issue Positive Shareholder Newsletter 4Health News:Nuvilex to Issue Positive Shareholder Newsletter 5Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 2Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 3Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 4Health News:Childrens Hospital Los Angeles Completes Conversion to Masimo SET(R) Pulse Oximetry Technology 5Health News:Minorities have poorer results, higher rates of inappropriate surgery to prevent stroke 2Health News:Ellison Medical Foundation awards more than $1 million to mid-career scientists 2Health News:Covenant Medical Center to Pay U.S. $4.5 Million to Resolve False Claims Act Allegations 2Health News:Robin Leedy & Associates Wins Social Media Program For Union Springs Pharmaceuticals 2
... Sarmiento-style PTB tibial orthosis for fractures, ... closed-cell foam at bony prominences for ... 3 modular footpiece/shoe insert systems offers ... Velcro® design fits especially well in ...
Philadelphia™ Collar - Plastazote® with plastic anterior and posterior reinforcements. Hook-and-pile closure straps. Chin cradle reduces rotation. Occipital and mandibular pieces may be int...
... The Escort hip abduction brace is a lightweight ... joint technology, the Genesis Joint. The Escort ... easy to don and doff. Superior comfort ... this brace. , ,The Escort Hip ...
... Newport® Hip Management Systems are designed and ... orthosis for your patients. Innovative new options ... is built on the most successful patented ... the adjustable clamping disk design and the ...
Medicine Products: