Navigation Links
Scottish Scientists Test ‘Secret Weapon’ Against,Tumours

LONDON, March 8, 2007--Cancer Research UK scientists in Glasgow have devised a new method of attacking cancer cells. They report the findings in the Journal of Clinical Investigation* today (Thursday).

A team of scientists from the Beatson Institute for Cancer Research gave mice a chemical that caused cancer cells to commit suicide, significantly slowing the growth of the tumours they were carrying. The chemical kick started a gene called p73 that brings about cancer cell death.

This early research could pave the way for a new agent to stop tumours growing. The researchers suggest that sending the protein – called 37AA – directly into the bloodstream using a ‘nanoparticle’ delivery system could be a potential way to find and kill tumour cells that have spread as well as those in the primary tumour.

In further laboratory studies the research team found that the chemical could kill several types of cancer cells – including bowel, cervical and bone cells.

Lead researcher Dr Kevin Ryan, a Cancer Research UK senior research fellow and head of the Tumour Cell Death Laboratory at the Beatson Institute, said: “Our study has shown for the first time that the selective activation of a gene called p73 can cause cell death in tumours. We think this approach has the potential to be developed into an effective treatment for cancer.”

The gene p73 is related to p53 – one of the most important genes known to protect against the development of cancer. p53, known as the ‘guardian of the genome’, was first identified by Cancer Research UK scientists in London.

p53 is damaged in the vast majority of cancers so scientists across the globe are looking for ways to restore the gene as a way of treating the disease. However, in some cancers, p53 is damaged in such a way that its function cannot be restored. p73 is a promising alternativ e target because it is rarely defective in human cancers.

Dr Ryan added: “Previously we thought p73 was just a ‘sleeping partner’ of p53, so we’re really excited that we’ve found a way to harness its function to treat cancer. While our studies are still at a preliminary stage, the next phase of our work is going to focus on developing a drug that mimics the effect of the 37AA protein. We hope this strategy could then be more readily tested for its potential development in human tumours.”

Professor Jim Cassidy, Cancer Research UK’s chair of medical oncology in Scotland said: “This fascinating piece of basic research has resulted in an experimental treatment that can cause malignant tumours to stop growing. In laboratory tests it killed a range of different cancer cells. We look forward to seeing if switching on p73 can translate into a treatment for patients.”

For media enquiries, please contact Emma Gilgunn-Jones in the press office on 020 7061 8311, or, out of hours, the duty press officer on 07050 264 059.

Notes to Editors:

*A novel p53-derived apoptotic peptide de-represses p73 to cause tumor regression in vivo. Helen S. Bell et al, 2007. Journal of Clinical Investigation.

This research was funded by Cancer Research UK with support from the Biotechnology and Biological Sciences Research Council (BBSRC) and the Ludwig Institute for Cancer Research.

Cancer Research UK - Together with its partners and supporters, Cancer Research UK's vision is to beat cancer. - Cancer Research UK carries out world-class research to improve understanding of the disease and find out how to prevent, diagnose and treat different kinds of cancer. - Cancer Research UK ensures that its findings are used to improve the lives of all cancer patients. - Cancer Research UK helps people to understand cancer, the progress that is being made and the choices each person can make.

- C ancer Research UK works in partnership with others to achieve the greatest impact in the global fight against cancer.

For further information about Cancer Research UK's work or to find out how to support the charity, please call 020 7009 8820 or visit www.cancerresearchuk.org.uk.


'"/>




Related medicine technology :

1. Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression
2. Schepens Scientists Identify Key to Integrating Transplanted Nerve Cells Into Injured Tissue
3. Karmanos Physician-Scientists Examine Racial Disparities in Patients with Gynecologic Cancer
4. Scientists Implicate Gene in Vitiligo and Other Autoimmune Diseases
5. The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem Cells Work Better
6. Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2017)... , June 2, 2017  NxStage Medical, Inc. (Nasdaq:  NXTM), a ... today announced new findings demonstrating positive biochemical outcomes related ... System One™. The data will be presented at the ... Madrid, Spain . The ... Home Dialysis Network in Europe ...
(Date:5/29/2017)... Israel, May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... technology which enables the functional selection of stem cells, ... for the first quarter ended March 31 st , ... our accomplishments in the first quarter of 2017," said ... quarter, we announced the treatment of the first blood ...
(Date:5/22/2017)... VALLEY COTTAGE, N.Y. , May 22, 2017 ... natural antiviral treatment Gene-Eden-VIR/Novirin, announces the launch of ... in plain English, the results of a clinical ... after one year treatment with Gene-Eden-VIR/Novirin in individuals ... is important to note that there are no ...
Breaking Medicine Technology:
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent Care ... MD Now’s 28th facility overall and marks the urgent care center's eighth location in ... North of The Falls shopping mall. The new clinic offers a wide array of ...
(Date:6/23/2017)... ... ... American Farmer, will feature Chr. Hansen, Inc (CHR Hansen) in an upcoming episode ... Farmer airs Tuesdays at 8:30aET on RFD-TV. Check your local listings for more info. ... 1874 after a groundbreaking discovery of how to industrialize enzymes. Rooted in science and ...
(Date:6/23/2017)... Chicago, IL (PRWEB) , ... June 23, 2017 ... ... insurance management assistance and financial planning services to communities in the greater Chicago ... Children’s Association to offer assistance to underprivileged youth in Chicago. , Founded in ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, ... area with access to asset protection and financial planning services, is teaming up ... improving the lives of children with cancer and other chronic diseases. , The ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... is pleased to welcome Whipple & Company as its newest Partner Firm. Headquartered ... of balancing their clients’ risk while tailoring optimized benefit packages that strengthen the ...
Breaking Medicine News(10 mins):