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Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds

beta-lactams tested against pneumococci that were not susceptible to ceftriaxone, selected from a recent U.S. collection of clinical isolates (P2025), supporting the potential use of ceftobiprole in the treatment of pneumonia.

Further microbiological data illustrate that the in vitro activity of ceftobiprole against some of the most common Gram-negative pathogens such as the Enterobacteriaceae and Pseudomonas aeruginosa is comparable to that of extended-spectrum cephalosporins (P780, P2024, P2026). In one study, ceftobiprole showed greater in vitro potency than piperacillin/tazobactam against Pseudomonas aeruginosa (P2026).

The pharmacological characteristics of dosing ceftobiprole 500 mg three times daily with a 2-hour infusion were presented for the first time (P779). Ceftobiprole did not cause QT prolongation in a thorough QT assessment of therapeutic (500mg) and supratherapeutic (1000mg) doses (P783).

Basilea's antifungal isavuconazole for the potential treatment of invasive fungal infections is in phase III testing in a global trial program in patients with invasive candidiasis including candidemia and patients with proven or probable aspergillosis.

New microbiological surveillance data relevant for the treatment of candidemia demonstrated isavuconazole's superior coverage of different candida species and most fluconazole-resistant isolates compared to other azole drugs (P1978). Potent activity against candida is further supported by data from a thorough analysis in animal models (P1950). Additionally, Cryptococcus neoformans, a yeast species not typically covered by the candin class, is highly susceptible to isavuconazole (P1977).

In animal models of aspergillus infection, isavuconazole showed at relevant plasma concentrations potent efficacy against several strains of Aspergillus fumigatus including an itraconazole-resistant strain (P1951). Aspergillus fumigatus is the mo
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