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Santaris Pharma Presents Positive Clinical Data on SPC2996 in,Chronic Lymphocytic Leukaemia

nderlying genetic causes of disease rather than just the physical symptoms. Santaris Pharma holds the world wide patent rights to the exploitation of LNA in pharmaceuticals and presently has three drugs in preclinical or clinical development. The lead drug candidate, SPC2996, is currently undergoing international, multicenter, phase I/II clinical studies in Chronic Lymphocytic Leukemia (CLL).

For further company information see www.santaris.com

Detailed results of the Phase I/II Study

A PDF of the results presented at the American Society of Clinical Oncology (ASCO) in poster format can be viewed and/or downloaded from the News section of the Company's website, www.santaris.com.

The Clinical Trial reported here was an open-label, international, multi-centre, dose-escalating study in 25 patients with relapsed or refractory Chronic Lymphocytic Leukaemia, requiring treatment. Twelve expert haematology-oncology specialists participated, including:

* Prof Bertrand Coiffier, Centre Hospitalier, Lyon-Sud, France (International Coordinating Investigator);

* Prof Hervé Tilly, Centre Henri Becquerel, Rouen, France (ASCO Presenter);

* Dr Bruno Cazin, Hopital Huriez, Lille, France;

* Prof Mauricette Michallet, Hoptial Edourd Heriot, Lyon, France;

* Prof John Radford, Christie Hospital NHS Trust, Manchester, UK (Prinicipal Investigator, UK);

* Dr Claire Dearden, The Royal Marsden NHS Foundation Trust, Surrey, UK;

* Prof Peter Hillman, Leeds General Infirmary, Leeds, UK;

* Prof Martin Dyer, MRC Toxicology Unit, Leicester, UK;

* Dr Christian Geisler, Rigshopitalet, Copenhagen, Denmark (Principal Investigator, Denmark);

* Dr Ole Gadeber, Vejle Sygehus, Vejle, Denmark;

* Dr Annemarie Dalseg, KAS Herlev, Herlev, Denmark;

* Dr Brian Link, Holden Comprehensiv
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