Navigation Links
Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data,From Nerve Regeneration Program at American Society for Neural,Therapy and Repair Meeting

Statistically Significant Improvements in Function in Spinal Cord Injury Model With ZFP TF Treatment

RICHMOND, Calif., May 03, 2007 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. announced today the presentation of preclinical data from its ZFP Therapeutic(TM) program in nerve regeneration at the Fourteenth Annual Conference of the American Society for Neural Therapy and Repair. The data generated, in a model of spinal cord injury (SCI), demonstrate that treatment of the spinal cord at the time of injury with a VEGF ZFP TF had a statistically significant effect on recovery of hind-limb function as well as a number of other measures of nerve integrity and health.

The work was carried out in the laboratory of Dr. Michael Fehlings who holds the Krembil Chair in Neural Repair and Regeneration at the Krembil Neuroscience Center, Toronto Western Hospital and the Division of Neurosurgery, Faculty of Medicine, University of Toronto, Ontario, Canada. Dr. Fehlings is a Christopher Reeve Foundation Scientific Advisory Council member and a leading expert in the molecular mechanisms and treatment of SCI.

In collaboration with Dr. Fehlings and his colleagues, Sangamo is evaluating a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)), designed to upregulate the expression of the gene encoding vascular endothelial growth factor (VEGF-A) in spinal cord injury (SCI) models. In addition to its effects on angiogenesis or blood vessel growth, VEGF-A has been demonstrated to have direct neurotrophic and neuroprotective properties in several models that assess nerve integrity and health. In addition, Sangamo is currently developing SB-509, a plasmid formulation of this same ZFP TF, for the treatment of diabetic neuropathy and has two ongoing Phase 2 trials in this area.

Dr. Fehlings and his colleagues observed that administration of the ZFP TF into the spinal cord at the time of injury produce
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Sangamo BioSciences Announces Presentation of Phase 1 ZFP Therapeutic Data at American Diabetes Association Meeting
2. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
3. YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy
4. IR BioSciences Announces Promising Data from Study of Its Compound Homspera
5. YM BioSciences Reports AeroLEF Randomized Phase IIb Trial Meets Primary Endpoint in Patients with Post-Surgical Pain
6. ImmuneRegen BioSciences Announces Promising Data on Homspera Suggesting Potential as a Co-Therapeutic Agent
7. Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein
8. IR BioSciences Announces Data Demonstrating Radilex Stimulation of Stem Cells Results in Hematopoietic Recovery Following Lethal Irradiation
9. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
10. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
11. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
Post Your Comments:
(Date:1/15/2014)... 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced ... Global Industry Analysis, Size, Share, Growth, Trends And Forecast, ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... patients in order to treat dental impairments, for tooth ...
(Date:1/15/2014)... AARP Foundation today announced it has established a relief ... cold weather that has gripped much of the nation. AARP ... so to support these emergency relief efforts AARP and AARP ... mean up to $500,000 in aid. The matching program will ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... received commitments from institutional investors to purchase an aggregate ... in an at-the-market registered direct offering, led by a ... into definitive purchase agreements with these investors pursuant to ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... 9, 2012 SciVerse Hub, SciVerse Applications, ... Sciences Recognized for Innovation and Achievement ... medical information products and services, today announced that it ... American Publishers Awards for Professional and Scholarly Excellence (the ...
... SAN DIEGO, Feb. 9, 2012  Volcano Corporation (NASDAQ: ... precision guided therapy tools designed to enhance the diagnosis ... announced it will report its operating results for the ... The company will hold a conference call ...
Cached Medicine Technology:Elsevier Honored With Six PROSE Awards 2Elsevier Honored With Six PROSE Awards 3Volcano Corporation Schedules Fourth Quarter Conference Call, Webcast 2
(Date:7/9/2014)... Health Organization recommends that youth participate in a minimum ... (MVPA) each day. Studies have shown that youth ... Therefore, it stands to reason that increasing outdoor time ... new study scheduled for publication in The Journal ... after school was positively associated with MVPA. , Drs. ...
(Date:7/9/2014)... (PHILADELPHIA) Researchers at the Perelman School of Medicine ... Roswell Park Cancer Institute have received an $8 million ... the effects of photodynamic light therapy (PDT) in patients ... cancer that most often manifests itself in the lining ... exposure to asbestos. The grant will fund a clinical ...
(Date:7/9/2014)... of lung cancer, researchers have uncovered mutations in a ... The new knowledge may expand treatments for patients because ... available or are in clinical trials. , Reporting July ... Genome Atlas (TCGA), including researchers at Washington University School ... other institutions, studied tumors from 230 patients with lung ...
(Date:7/9/2014)... in policing injection drug users in Russia might ... , A study, conducted by researchers from Boston ... collaboration with St. Petersburg Pavlov State University, sought ... the health outcomes of a cohort of HIV-positive ... Those who were arrested by police were more ...
(Date:7/9/2014)... July 9, 2014 There has been a sharp ... Southwestern Medical Center using MyChart, the online, interactive service ... communicate with their healthcare providers, schedule appointments, and renew ... patients actively using MyChart each year increased ... increased more than 10-fold, according to a study by ...
Breaking Medicine News(10 mins):Health News:Go play outside! Outdoor time promotes physical activity in youth 2Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Lung cancer study hints at new treatments 2Health News:BU researchers relate arrests with HIV risk environment 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3
... , LYNBROOK, N.Y., Sept. 16 ... a biopharmaceutical company developing first-in-class collagenase-based products, today announced ... Food and Drug Administration,s (FDA) unanimously recommended by a ... histolyticum), a novel, first-in-class, orphan-designated, biologic, be granted marketing ...
... published online today [Thursday] estimates nearly 45,000 annual deaths are ... two and a half times higher than an estimate from ... study, "Health Insurance and Mortality in U.S. Adults," appears in ... Public Health . The Harvard-based researchers found that uninsured, ...
... , SAN FRANCISCO, Sept. 21 Medithrive, Inc., ... its state of the art dispensary, offering patients a beautiful ... of medicinal marijuana products. , , ... 16th, in San Francisco, CA, has positioned itself as the ...
... post-menopausal women with early breast cancer to the drug exemestane ... keeping them on tamoxifen for five years improves the chance ... for at least the next six years. "These ... mid-way through the five-year tamoxifen treatment plan provides a clear ...
... CINCINNATICancer predisposition resulting from the presence of a ... researchers at the University of Cincinnati (UC) have ... risk for development of cancer in individuals harboring ... a result of environmental exposure. Peter Stambrook, PhD, ...
... NEW YORK, Sept. 21 In a bid ... online auction of the Ysio Digital Radiology System. As the ... N.Y., presented them a check for $285,309. , , ... , http://inr.mediaseed.tv/oneClip_C/?feed=hK4UKEtcAILqy08qpCX6wBwEMnTvqjZg , , ...
Cached Medicine News:Health News:FDA Advisory Committee Unanimously Recommends Approval of XIAFLEX(TM) for Treatment of Dupuytren's Disease 2Health News:FDA Advisory Committee Unanimously Recommends Approval of XIAFLEX(TM) for Treatment of Dupuytren's Disease 3Health News:45,000 excess deaths annually linked to lack of health insurance: Harvard study 2Health News:Switching early breast cancer patients to exemestane improves long-term survival 2Health News:Cancer predisposition from genetic variation shows strong gender bias 2
... Pneumoniae Antibody (IgG) Test is a semiquantitative ... clinically significant IgG antibodies to M. pneumoniae ... The test should not be used for ... Antibody (IgM) Test and is not intended ...
... is a qualitative enzyme immunoassay (EIA) ... virus capsid antigen (EBV-VCA), Epstein-Barr early ... Toxoplasma. When used in conjunction with ... in the serodiagnosis of infectious (EBV) ...
... ImmunoDOT TORCH Test is an ... for determining the presence of ... virus, cytomegalovirus and herpes simplex ... whole blood to indicate previous ...
... DotBlot G Tests are qualitative enzyme immunoassays ... burgdorferi antibodies (IgG or IgM, respectively) in ... tests should be supplemented with a standardized ... be used to support a clinical diagnosis ...
Medicine Products: