Navigation Links
Roxro Pharma’s Novel Intranasal Pain Reliever Effective, Well,Tolerated in Phase 3 Study

Patients Using ROX-888 Required Significantly Less Morphine After Major Abdominal Surgery Company On Track To File NDA In 2008

MENLO PARK, CA (June 6, 2007) – ROXRO PHARMA Inc. said today that ROX-888, its novel intranasal analgesic, rapidly and effectively eased pain and was well tolerated by patients who had undergone major abdominal surgery in a Phase 3 clinical study.

"This completes our second and final Phase 3 clinical study," said ROXRO PHARMA’s Chief Scientific Officer Roger Whiting. The company intends to include fully analyzed data in its New Drug Application for submission to the U.S. Food and Drug Administration. "We are very pleased with the solid results of this Phase 3 study and are on track to file our NDA in the first half of 2008," Whiting said.

In the Phase 3 study, patients who received ROX-888 reported greater improvement in pain relief and required 22 percent less morphine in the first 24 hours following surgery compared to patients who had access to morphine alone. ROX-888 is an intranasal formulation of ketorolac, a non-steroidal anti-inflammatory medicine most often administered as an intramuscular injection or intravenously for the short-term treatment of moderately severe pain. "ROX-888 is an important breakthrough in treating pain," said Dr. Neil Singla, Director of Clinical Research at Huntington Memorial Hospital in Los Angeles. "It is rapidly absorbed into the bloodstream, and relieves pain as fast as an intramuscular injection. There is a need for new analgesics like ROX-888 that do not have the troublesome side effects and abuse risks associated with narcotic pain relievers." The Phase 3 double-blind, placebo-controlled study included 321 patients who had undergone major abdominal surgery. Patients were randomized to receive either intranasal ketorolac (30 mg) or placebo. All study participants had access to patient-controlled morphine. "Pain is at its greatest intensity in the first 24
'"/>




Page: 1 2

Related medicine technology :

1. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
2. Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science
3. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
6. Novel Mechanism Insights and Additional Data on CombinatoRx Drug Candidates to Be Presented at Upcoming EULAR Meeting
7. Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
8. Metabasis Therapeutics Presents Results of Preclinical Studies for MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, at the Endocrine Societys Annual Meeting
9. Encouraging Clinical Activity of GSKs Novel Cancer Immunotherapeutic Confirmed in Phase II Study in Patients with Most Common Form of Lung Cancer
10. Clinical Data on ARIADs Novel mTOR Inhibitor, AP23573, To Be Presented at the ASCO Annual Meeting
11. VGX Pharmaceuticals Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models
Post Your Comments:
(Date:10/22/2014)...  Charlene Vernak, RPh, of Vernak Farms Pharmacy in ... awarded the George Roentsch Scholarship by the Professional Compounding ... Houston during PCCA,s International Seminar, ... to an independent pharmacist and PCCA member who embodies ... , a well-known pharmacist in the compounding community. ...
(Date:10/22/2014)... 22, 2014 A new report ... (Product type, Form, End user, Application and Geography) - ... Research, Report, Opportunities, Segmentation and Forecast, 2013 - 2020", ... Based on key trends tracked, it is anticipated that ... billion by 2020, registering a CAGR of 6.2% from ...
(Date:10/22/2014)... 21, 2014  Early symptoms of diabetic eye ... but new technology, coupled with yearly, comprehensive eye ... earlier detection of eye diseases, including those associated ... If left untreated, these diseases can potentially lead ... Recently, optometric researchers have deployed a new ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
... Va., Oct. 1 Today, PARI Respiratory Equipment introduced the ... can be used with all PARI LC reusable nebulizers. ... with nebulizer therapies for airway clearance and lung strengthening exercises ... PEP S is an incredible new device that improves patient ...
... WOODLAND HILLS, Calif., Oct. 1 In a continued ... forefront, Anthem Blue Cross, State Sponsored Business launched an ... a virtual BMI wheel and web-based interactive practice sessions ... launch of the online BMI training program builds on ...
Cached Medicine Technology:PARI Respiratory Launches PEP S 2Anthem Blue Cross Takes BMI Training Virtual with New Online Capability 2Anthem Blue Cross Takes BMI Training Virtual with New Online Capability 3
(Date:10/25/2014)... (PRWEB) October 25, 2014 More than ... President’s Circle Reception on Monday at the home of ... and hear from guest speaker Dr. Winifred Lender on ... , Dr. Lender, a Santa Barbara psychologist, author and ... and benefits of living in the digital age. Our ...
(Date:10/25/2014)... October 25, 2014 QueenBeeTickets.com has a ... great selection at affordable prices. Bob Seger & The ... Center and Nationwide Arena are going on sale October ... Click Here to browse the selection of tickets ... QueenBeeTickets.com. , The famous singer is touring North America ...
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Interrupting blood supply ... help reduce the risks associated with the surgery, according to ... to stop the blood supply to the heart to be ... blood, the heart will reduce its ability to produce energy ... blood flow to another large muscle, such as an arm ...
(Date:10/25/2014)... -- Current osteoporosis screening guidelines and tools fail ... for osteoporosis-related fractures, a new study says. ... tools that help us accurately predict who will ... target these at-risk people for preventive measures," study ... the division of general internal medicine and health ...
(Date:10/22/2014)... Austin, TX (PRWEB) October 22, 2014 ... Criminal Minds featuring skin diseases both fictional ... Foundation (CEHMDF), a nonprofit organization committed to advocacy ... wondering if CBS will take the opportunity to impart ... disease. , There are many misconceptions about ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3
... Governors,University (http://www.wgu.edu ) is now offering its ... managers and nurse educators. These,scholarships are designed to ... become educators, managers, and leaders in various healthcare,settings. ... and,M.S. in Nursing-Leadership and Management degree programs., ...
... Oct. 17 Collaborative Drug Discovery,Inc. (CDD, Inc.) ... of,recent publications focused on the fight against Chagas, ... available to researchers free of charge, via,the CDD ... Chemistry, Bioorganic &,Medicinal Chemistry, the Journal of American ...
... Looks to Add Even More Space in the ... W.Va., ReBuilder Medical Technologies,Inc. (Pink Sheets: RBRM), ... device inventor David B. Phillips, Ph.D., today,announced it ... demand,of it cutting edge medical devices and products. ...
... Pacific Design ... WEST HOLLYWOOD, Calif., Oct. 17 Charles S. Cohen,visionary ... to support AIDS Walk Los Angeles and the City of ... Angeles, in addition to,providing Pacific Design Center as the official ...
... consumers manage costs and adopt healthier ... ... in Virginia is now offering new health plan options for employers,and individuals ... healthier lives and gain control over the rising,cost of care. These consumer ...
... the Way Toward Malaria ... Eradication U.S. Presidential Candidates Urged to Sustain and Expand President,s ... Malaria Initiative, SEATTLE, Oct. ... - to reach a,day when no human being has malaria, and no mosquito on earth ...
Cached Medicine News:Health News:Nursing Scholarships Offered by Western Governors University for Master's Degree Programs 2Health News:Free Access to Literature Data on Chagas' Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with 'archive mine and collaborate' access to small molecule bioactivity SAR data on parasitic disease 2Health News:ReBuilder Medical Technologies, Inc. Increases Manufacturing Space to Meet Demand 2Health News:ReBuilder Medical Technologies, Inc. Increases Manufacturing Space to Meet Demand 3Health News:Charles S. Cohen, Pacific Design Center Augment Their Support for AIDS Walk Los Angeles 2Health News:Charles S. Cohen, Pacific Design Center Augment Their Support for AIDS Walk Los Angeles 3Health News:Anthem Blue Cross and Blue Shield in Virginia Introduces New Generation of Consumer Driven Health Products 2Health News:Anthem Blue Cross and Blue Shield in Virginia Introduces New Generation of Consumer Driven Health Products 3Health News:Anthem Blue Cross and Blue Shield in Virginia Introduces New Generation of Consumer Driven Health Products 4Health News:Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication 2Health News:Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: