( Neurological disability typically accum...)Rituxan Phase II Data in Patients with Relapsing-Remitting Multiple,Sclerosis Presented at the American Academy of Neurology,Health

Neurological disability typically accumulates over time and includes muscle weakness and spasticity, balance and coordination problems, as well as memory impairment and depression. Other symptoms include numbness, pain, slurred speech and blurred vision. Many patients experience fatigue and problems with bladder, bowel or sexual function.

While MS has traditionally been considered a T-cell mediated disease, recent research suggests that B-cells may play multiple roles in the initiation and development of MS.

Rituxan Safety Profile in Rheumatoid Arthritis and Oncology
The safety profile of Rituxan in rheumatoid arthritis and non-Hodgkin's lymphoma (NHL) has been evaluated through a number of clinical trials.

The most common adverse events observed in rheumatoid arthritis (RA) patients treated with Rituxan in clinical studies of up to 24 weeks were infection and infusion reactions. Among non-Hodgkin's lymphoma patients treated with Rituxan in clinical studies, the most common adverse events were infusion reactions and cytopenias (low blood cell counts).

The majority of patients experiencing an infusion-related reaction do so during their first Rituxan infusion. These symptoms include but are not limited to: flu-like illness, fever, chills/rigors, nausea, urticaria, headache, bronchospasm, angioedema, hypotension and hypoxia. These symptoms vary in severity and generally are reversible.

Severe infusion reactions have been reported in patients treated with Rituxan, some with fatal outcomes. These severe reactions typically occur during the first infusion. The most severe manifestations and sequelae include hypoxia, pulmonary infiltrates, acute respiratory distress syndrome, myocardial infarction, ventricular fibrillation and cardiogenic shock.

Acute renal failure requiring dialysis with instances of fatal outcome has been reported in the setting of tumor lysis syndrome following treatment with Rituxan in patients wi
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