Navigation Links
Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV,Activity

Rigel Program to be Presented at Keystone Scientific Meeting

SOUTH SAN FRANCISCO, Calif., March 27, 2007 /PRNewswire-FirstCall/ -- Rigel today announced that Yonchu Jenkins, Ph.D., Associate Director of Virology, will be presenting on the company's efforts to develop a small molecule therapeutic to treat patients with the Human Immunodeficiency Virus (HIV) infection at the Keystone Symposium in British Columbia on March 27th and 29th. Dr. Jenkins will present both a poster and an oral presentation entitled, the Identification of Novel Antiretroviral Compounds by Targeting HIV Vif Function.

Dr. Jenkins and her colleagues at Rigel are investigating ways to inhibit Vif, a specific viral protein produced by HIV that is essential for its replication. Inside HIV-infected cells, the invading protein, Vif, neutralizes the potent anti-viral activity of a host human protein called Apobec3G. By recruiting Apobec3G into an ubiquitin ligase complex, Vif enables the subsequent degradation of Apobec3G, thus eradicating it from HIV-infected cells. When Vif is absent, Apobec3G's potent anti-viral activity renders HIV virus particles non-infectious. Rigel is exploring a number of small molecule compounds aimed at modulating the intracellular ubiquitin ligase signaling pathways utilized by Vif so that Apobec3G will remain active in the presence of HIV and impede the virus from replicating.

"Our approach focuses on restoring the body's natural ability to fight the virus by means of a ubiquitin ligase target. By focusing on a host target, rather than a viral target we may create a new class of anti-retroviral therapeutics," said Donald G. Payan, M.D., Executive Vice President and Chief Scientific Officer of Rigel. "Rigel is uniquely positioned to pursue this target given our extensive experience in the ubiquitin ligase field and in the virology area," he added.

For further information on Rigel's HIV program, Dr
'"/>




Page: 1 2 3

Related medicine technology :

1. Rigel to Present New Research Programs at AACR Meeting
2. Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP, Rheumatoid Arthritis and Lymphoma
3. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
4. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
5. Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
6. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
7. Amylin Pharmaceuticals to Present New Data from Broad Diabetes and Obesity Programs at ADA 2007
8. Ambrilia Highlights Encouraging Data for its HIV Integrase Inhibitor Program and Recent Developments at Annual Meeting
9. CuraGen Presents Update on Clinical Development Program for Belinostat
10. Hana Biosciences Presents Data On Two Programs At the American Society of Clinical Oncology Annual Meeting
11. Diatos Announces Positive Clinical Results for its DTS-201 Doxorubicin Prodrug Program
Post Your Comments:
(Date:1/23/2015)... 2015  iMD Companies, Inc. (ICBU) has repositioned itself as a ... grab a foothold in the hydroponic, hemp and medical marijuana ... presence in the sector, and recently partnering with the Chippewa ... and medical marijuana, iMD is committing to bring its vision ...
(Date:1/23/2015)... 23, 2015   Leatt Corporation  (OTCQB: LEAT), a global ... all forms of sports, including extreme motor sports, and ... today that the UISP Lega Motociclismo Lombardia, an Italian ... to wear a neck brace during its racing competitions.  ...
(Date:1/23/2015)... Ala. , Jan. 23, 2015 Gem Pharmaceuticals ... patients have been enrolled into the Company,s Phase 2 ... and safety of Gem,s lead compound, GPX-150 (an investigational ... advanced or metastatic disease. Logo - ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
(Date:1/23/2015)... AZ (PRWEB) January 23, 2015 Hastings and ... injury matters, reports a record number of legal representation client ... speaking, there has been a steady rise in the number ... work and at home throughout the Valley. With that said, ... accident be reviewed by an experienced law firm. Hastings and ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The City of West ... 10 a.m., to commemorate the 42nd anniversary of the Supreme Court ... , “It’s been 42 years since the Roe vs. Wade decision ... still as present as ever,” said City of West Hollywood Councilmember ...
(Date:1/22/2015)... 22, 2015 The Incredible Bulk is a ... to increase lean muscle by up to 30lbs in less ... attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , ... a step-by-step, scientific diet formula that allows the body to ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... has released a new blog post presenting the basic features ... Purchasing an accidental death and dismemberment rider for a car ... provides benefits if the insured dies in an accident. Accidental ... life insurance. , AD&D is not expensive and can ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... Trust (PCT) has been asked by a court to reconsider giving ... Court was told that// the drug had not been approved for ... that it was not legal that the NHS refuses to fund ... to raise false hopes to have a trial and then say ...
... psychiatrists here who have come up with innovative ways of ... of flooding.// ,A team of psychiatrists is urging people ... motivational song when they can. ,While the song ... have convinced mobile telephone companies to offer it and similar ...
... that women going in for alternative therapies to treat ... are at the risk of harming themselves.// ,The ... the therapies may not be very effective. Though, there ... there is also a risk of stomach upset and ...
... possibility of adverse effects with the use of the new ... new study that is set to appear in this month’s ... the use of the new group of drugs known as ... osteoporosis. They have claimed to find in their research that ...
... new study has revealed that most people are eating and drinking ... In fact even the extra orange juice we consume could add ... up with the idea of replicating a portion-size study from 20 ... "typical portion" of meal items from a buffet table. The responses ...
... shows that COX-2 inhibitor 'Rofecoxib' might be effective ... ,According to a new, 'A Randomized Trial ... being published in Gastroenterology, the journal for the ... (COX-2) inhibitor Rofecoxib cuts the risk of colorectal ...
Cached Medicine News:Health News:Songs Could Help to Overcome Flood Trauma 2Health News:Alternative therapy – an alternative to HRT 2Health News:Alternative therapy – an alternative to HRT 3Health News:Estrens For Osteoporosis Might Have Adverse effects 2Health News:Risk Of Colorectal Polyps Recurrence Can Be Controlled By Rofecoxib 2Health News:Risk Of Colorectal Polyps Recurrence Can Be Controlled By Rofecoxib 3Health News:Risk Of Colorectal Polyps Recurrence Can Be Controlled By Rofecoxib 4
The Livewire steerable electrophysiology catheter is uniquely designed with an ergonomic handle and patented steering mechanism to provide smooth, precise catheter tip movement, even during lengthy e...
The Livewire cannulator offers improved access to the coronary sinus by combining the ergonomic Livewire steering mechanism with numerous specialized features....
Trilogy Pacemakers incorporates the clinically proven Omniscence™ accelerometer sensor with it's automatic alogorithms. The Trilogy family of pacemakers feature an array of products for bradyar...
... The Identity pacemaker family, ... dual-chamber pacemaker, provides clinicians with ... available, including the revolutionary AF ... only U.S. commercially approved algorithm ...
Medicine Products: