Navigation Links
Resveratrol Studies Suggest Broad Implications for SIRT1 Activation,in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 26, 2007 - Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced today that activation of SIRT1, a member of the sirtuin family of enzymes, was shown to protect against neurodegenerative diseases such as Alzheimer's Disease and Amyotrophic Lateral Sclerosis in animal models. These findings appear in an article published in Volume 26, Number 13 of The European Molecular Biology Organization Journal (EMBO), Kim et al., 2007 entitled "SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis" which is also available now in the advance online publication.

It is well established that a progressive loss of neurons with age underlies a variety of debilitating neurological disorders including Alzheimer's Disease and Amyotrophic Lateral Sclerosis (ALS), neurodegenerative diseases which have been associated with reduced mitochondrial function. Sirtuins are a recently discovered class of enzymes that appear to affect the aging process in mammals and increase the number and function of mitochondria.

According to the findings in this paper, resveratrol, a SIRT1 activator, reduced the loss of neuronal function in the brain (hippocampus) and prevented learning impairment in a well established animal model of Alzheimer's Disease. This response was associated with SIRT1 dependent deacetylation of PGC1a. Resveratrol also promoted neuronal survival in cell based models of Alzheimer's Disease and ALS.

The three senior authors of the EMBO article include Sirtris co-founder and co-chair of the Scientific Advisory Board (SAB), David A. Sinclair, Ph.D., Department of Pathology and Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, and Sirtris SAB members Li-Huei Tsai
'"/>




Page: 1 2 3

Related medicine technology :

1. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
2. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
3. Studies of Drug Resistance May Lead to Individual Therapy for Rare Cancers
4. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
5. Insmed Inc. Welcomes Studies Linking IGFBP-3 to Prevention of Blindness in Premature Infants
6. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
7. Phosphagenics Announces Positive Proof of Concept Results from Studies Utilizing Companys Dermal Drug Delivery Technology
8. New Data from Multiple Studies Show Galvus Delivers Consistent and Robust Blood Sugar Control in Patients with Type 2 Diabetes
9. Eurands Zentase Effective in Treating Exocrine Pancreatic Insufficiency, Studies Show
10. Three Studies Suggest Abbotts Humira (adalimumab) May Improve Work Productivity in Patients with Rheumatoid Arthritis
11. Neurogen Proprietary Insomnia Compound Data for Two Studies Presented at Associated Professional Sleep Societies Annual Meeting
Post Your Comments:
(Date:12/24/2014)... , Dec. 24, 2014  Conkwest, Inc., the ... the proprietary Natural Killer (NK) cell-line platform, Neukoplast® ... Patrick Soon-Shiong , NantWorks founder, physician scientist ... agreement to purchase approximately $48 million of the ... the investment, he will be named Co-Chairman of ...
(Date:12/24/2014)... YORK and LONDON , ... global orthopedic industry are expected to grow at an ... in terms of value and volume. Hip, knee and ... developed world while in emerging economies they have a ... rates are challenging the use of composites. Non-metallic orthopedic ...
(Date:12/24/2014)... 2014  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), ... the development of brachytherapy devices and medical isotopes ... it has filed a de novo ... for marketing clearance for its patented Y-90 RadioGel(TM) ... Food, Drug and Cosmetic Act (the "Act").  ...
Breaking Medicine Technology:Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... further study on meningococcal infection. He suggests that an ... to better understand, and further prevent, the bacterial infection. ... since its introduction in 2003, but the disease incidence ... could do better," Dr Patel said. ,In ...
... affects the bacterial composition of the oral cavity even in ... high intake is needed to counteract the production of acid ... that is produced by reduction of the sugar xylose, or ... as pears and strawberries. It is used in sugarless sweets, ...
... morbidity rate in the Indian capital is 17 per thousand ... government study said Thursday. ,The report - Morbidity, ... by the directorate of economics and statistics of the state ... the lowest among all the states. ,"The morbidity ...
... Hopkins brain scientists have found why some powerful drugs ... weight rather than develop complications like diabetes and heart ... of antipsychotics to natural brain chemicals that trigger appetite,” ... the Johns Hopkins School of Medicine. “Our identification of ...
... could not be prouder to announce it will launch ... a fetus with a known birth defect. Set to ... Unit will offer comprehensive medical care, from prenatal diagnosis ... eight-bed labor and delivery unit will allow Children’s Hospital’s ...
... A latest research suggests that human brain can continuously produce ... the treatment of diseases like Alzheimer’s.// This research was undertaken ... the Sahlgrenska Academy in Sweden. ,Stem cells reside ... team observed in human beings that these cells move to ...
Cached Medicine News:Health News:More Research on Meningococcal Infection Called for 2Health News:Xylitol Fights Oral Bacteria 2Health News:Delhi's Morbidity Rate Nearly One-sixth of National Average 2Health News:Scientists Uncover Cause of Antipsychotic Drug Weight Gain 2Health News:Special Delivery Unit for Pregnant Moms With Birth Defects in Fetus 2
CCR Medical conventional laryngoscope handles....
... Wire-Reinforced LMA ™ Airway., ,The ... tube which allows it to be ... while maintaining a good seal. This ... and dental surgery, or other procedures ...
... Airway. , ,Developed for cardiopulmonary resuscitation ... the LMA Fastrach™ has been designed to ... or neck. The LMA Fastrach™ allows continuous ... by emergency teams worldwide including NASA for ...
... in the production of airway ... an integrated solution to all ... single-use Portex Soft Seal Laryngeal ... to this wide portfolio of ...
Medicine Products: