Navigation Links
Researchers Identify Intracellular Pathway of Alfacell's Onconase

Paper Published in Journal of Cell Science Shows ONCONASE Uptake in Cells Differs from other RNases

BLOOMFIELD, N.J., April 05, 2007 /PRNewswire-FirstCall/ -- Alfacell Corporation today announced that European researchers have identified the pathway that ONCONASE (ranpirnase) follows to enter cells.

Published in the Journal of Cell Science (2007; 120: 1405-1411), a paper based on studies conducted at the University of Girona in Spain and the University of Montpellier II in France shows that ONCONASE enters cells using AP-2/clathrin-mediated endocytosis, enabling its subsequent delivery to the cytosol. The published data indicate that unlike other RNases, the ONCONASE endocytosis pathway is not targeted to lysosomes.

"ONCONASE has a very specific property in that it is selectively toxic to malignant cells," said Kuslima Shogen, Alfacell's chairman and chief executive officer. "The Journal of Cell Science paper is another reflection of the strong interest that the scientific and medical communities have in understanding ONCONASE's performance. Ongoing independent research like this at leading institutions is providing us with further data that is useful in our efforts to expand the potential therapeutic opportunities for our technology platform."

About ONCONASE(R)

ONCONASE is a first-in-class therapeutic product candidate based on Alfacell's proprietary ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been shown in the laboratory and clinic to target cancer cells while sparing normal cells. ONCONASE triggers apoptosis, the natural death of cells, via multiple molecular mechanisms of action.

About Alfacell Corporation

Alfacell Corporation is the first company to advance a biopharmaceutical product candidate that works in a manner similar to RNA interference (RNAi) through late-stage clinical trials. The product candidate, ONCO
'"/>




Page: 1 2 3

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Researchers Discover Method for Identifying How Cancer Evades the Immune System
4. Researchers Discover Gene For Rare Skin Disorder
5. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
6. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
7. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
8. Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report
9. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
10. Researchers Urge Caution in Using ESAs for Cancer-Related Anemia
11. Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
Post Your Comments:
(Date:6/2/2015)... Research and Markets ( http://www.researchandmarkets.com/research/w3n5p6/drug_delivery_in ) ... report "Drug Delivery in Central Nervous System ... their offering. The delivery of drugs ... in the treatment of neurological disorders. Drugs may ... systematically (e.g., by intravenous injection) for targeted action ...
(Date:6/2/2015)... June 2, 2015 The Canadian Society for Vascular ... tests, treatments or procedures that are commonly ordered ... part of Choosing Wisely Canada.  The list identifies ... conversations between patients and physicians about what care ... for Vascular Surgery,s list identified the following five ...
(Date:6/2/2015)... , June 02, 2015 Research and Markets ( ... Archiving and Communication Systems (PACS) - Global Strategic Business Report" ... separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Latin America ... and forecasts are provided for the period 2014 through 2020. ...
Breaking Medicine Technology:Global Drug Delivery in Central Nervous System Diseases Report 2015-2024 - Technologies, Markets and Companies 2Global Drug Delivery in Central Nervous System Diseases Report 2015-2024 - Technologies, Markets and Companies 3As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 2As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 3As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 4Picture Archiving and Communication Systems (PACS) - Global Strategic Business Report 2015: User Demand Favors Integrated RIS/PACS Solutions 2
... Bend Research Inc. ( www.bendresearch.com ), a leading independent ... McLeod has joined the company as Chief Financial Officer. ... McLeod was formerly Director of Business Development with ... strategic vision is credited with improving many different parts ...
... 2011 Comprehensive Care Corporation (OTC BB: CHCR), which ... services for managed care companies throughout the U.S., today ... been praised by the Chamber of Commerce of the ... Advisory Council in "helping to shape and drive the ...
Cached Medicine Technology:Bend Research Announces New Chief Financial Officer 2Comprehensive Care Corporation CEO Clark A. Marcus Praised for U.S. Chamber of Commerce Service 2
(Date:6/2/2015)... The Down Syndrome Association of Wisconsin (DSAW) is ... Glee as the keynote speaker for its June 6, ... The event aims to raise funds to support programs ... counties. , "We couldn't be more ... event," says Dawn Nuoffer, DSAW Executive Director. "She's a ...
(Date:6/2/2015)... New Jersey (PRWEB) June 02, 2015 ... (Horizon BCBSNJ) announced today that its Walking and Wellness ... Classic Presented by Acer, has raised another $3,000 for ... Natalie Gulbis undertook the challenge, recording 32,000 steps on ... at Stockton Seaview Hotel & Golf Club in Galloway ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 “ Radaris ” ... which takes a look at the latest and coolest applications ... the host of AppWatch and technology expert, conducted the app ... the data they need on a person. , According to ... publication even goes on to explain that curiosity is a ...
(Date:6/2/2015)... October 1, 2015 the transition to ICD-10 will happen ... Monday, June 1st Congressman Kevin Brady, chairman of ... Committee, and 12 members of the Committee sent a ... the administration to provide a smooth transition for local ... newest coding system for healthcare professionals to code diseases, ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Claflin ... distributor, has announced the acquisition of RSI ... distributor, effective May 29th, 2015. , With CME’s recent ... this latest acquisition joins three premier organizations which specialize ... hospitals and healthcare facilities. By combining forces, they now ...
Breaking Medicine News(10 mins):Health News:Glee star Lauren Potter helps Down Syndrome Association of WI raise awareness, support 2Health News:LPGA’s Natalie Gulbis Raises an Additional $3,000 for the Boys & Girls Club of Atlantic City Through Horizon BCBSNJ’s Walking and Wellness Challenge 2Health News:A Comprehensive People Search Application Was Featured on NewsWatch Television 2Health News:HomeTown Health Launches a “100 Day Countdown” in Response to ICD-10 Survey 2Health News:HomeTown Health Launches a “100 Day Countdown” in Response to ICD-10 Survey 3Health News:HomeTown Health Launches a “100 Day Countdown” in Response to ICD-10 Survey 4Health News:Claflin Medical Equipment (CME) Announces Acquisition of RSI Equipment, Inc. 2
... , AUGUSTA, Ga. Scientists want to protect the optic nerve ... a car wreck. It,s called traumatic optic nerve damage when ... gets rattled, resulting in swelling and inflammation that can destroy its ... loss and blindness. "The optic nerve is not completely straight ...
... has named Takeo Kanade, the U.A. and Helen Whitaker ... Mellon University, the 2010 winner of the ACM/AAAI Allen ... and robotics. , The Newell Award, named for one ... Computer Science, recognizes career contributions that have breadth within ...
... lead-based ammunition as a potential health and environmental hazard, ... material for bullets tungsten may not be ... accumulates in major structures of the immune system in ... Toxicology . Jose Centeno and colleagues explain that ...
... 2011) Breast cancer is the second most common cancer ... Being exposed to estrogen over a long period of time ... developing the disease. One way a woman can combat ... tamoxifen, which interferes with the activity of estrogen. Now, ...
... not really be compatible with current beauty ideals, but, to a ... our body. However, it is a different matter if the organism ... This is a clear sign of a metabolic disorder. ... which is regarded a typical characteristic of the dangerous metabolic syndrome. ...
... , TUESDAY, April 5 (HealthDay News) -- In the ... researchers report that risks to postmenopausal women who were ... the treatment. The study found that when ... blood clots, which were elevated while they were on ...
Cached Medicine News:Health News:Better treatment sought for blinding traumatic optic nerve damage 2Health News:CMU's Takeo Kanade wins ACM/AAAI Award for career contributions to computer vision, robotics 2Health News:Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen 2Health News:Fatty liver -- how a serious problem arises 2Health News:Risks of Estrogen Hormone Therapy Seen to Fade After Treatment Ends 2Health News:Risks of Estrogen Hormone Therapy Seen to Fade After Treatment Ends 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: