Navigation Links
Researchers Discover a Common Variation in a Gene Segment that,Increases the Risk for Prostate Cancer

ng of a different variant, marked by SNP rs1447295, is also associated with prostate cancer. The rs1447295 SNP is located nearby on the same arm of chromosome 8. The old and the new susceptibility loci, or gene locations, appear to act independently; a change in one region did not affect the degree of risk conferred by the other. We now have two significant regions in the same general area that convey risk for prostate cancer. This will undoubtedly focus multidisciplinary studies on this stretch of DNA, called 8q24, said Meredith Yeager, Ph.D., lead author on the study.

The rs1447295 location could be responsible for about seven percent of prostate cancer cases in white men of north European descent. Thus, taken together with rs6983267, these two genetic changes could account for as much as one quarter of prostate cancer cases in white men. The increased risk conferred by these loci was observed for all age groups studied.

CGEMS allows us to look systematically across the entire human genome and search for common genetic variations that confer risk for prostate cancer, a very common and very complex disease said Stephen Chanock, M.D., director of NCIs Core Genotyping Facility in the Advanced Technology Center.

Identification of new regions like 8q24 furthers efforts to uncover the genetic basis of prostate cancer, which may eventually lead to more insights into cancer causation in general," added Gilles Thomas, M.D., Ph.D., lead scientist of CGEMS.

An initial genome-wide association study was conducted in 2,329 men from across the United States who are participating in the NCIs Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) that began in 1993. The PLCO analysis compared 1,172 men with prostate cancer to 1,157 who did not have cancer.

CGEMS results were further confirmed by a number of other studies, including the American Cancer Society Cancer Prevention Study II, the Health Professionals Follow-up Study, the
'"/>




Page: 1 2 3 4

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Researchers Discover Method for Identifying How Cancer Evades the Immune System
4. Researchers Discover Gene For Rare Skin Disorder
5. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
6. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
7. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
8. Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report
9. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
10. Researchers Urge Caution in Using ESAs for Cancer-Related Anemia
11. Researchers Identify New Genetic Risk Factors for Type 2 Diabetes

Post Your Comments:
(Date:11/24/2009)...Newswire/--Inadditiontofamily,friendsandhealth,can...toherThanksgivinggratitudelist. ,, "Theyheardth...esaidofMonday,sverdictstotaling$103millionindamage...g12,000womennationwidewhohavesuedWyethandPfizerpha...nandPrempro.Wisneskiandtheothervictimsofhormonethe...
(Date:11/24/2009)...swire/--Accumetrics,Inc.,aprivately-helddevelopera...andeasy-to-usediagnosticsystemformeasuringanindivi...vix®andaspirin),announcedtodaythatTimothyI.St...tts,ChiefFinancialOfficerofAccumetrics,willbeprese...HealthCareConferencebeingheldinNewYorkCityonDecemb...
(Date:11/24/2009)...RNewswire/--PharmaceuticalInstitute,aleadingprovid...alandbiotechindustry,todayannouncedthelaunchofanew...alMarketplace e-courseisthenewestadditiontothecomp...ensiveseriesofe-coursesdesignedtofillthecriticalne...mercialprofessionals. ,, Thenewthreemodule Hosp...
Breaking Medicine Technology:Maryland Woman Thankful for Wyeth Verdicts 2Accumetrics to Present at the 21st Annual Piper Jaffray Health Care Conference 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2SNMs Clinical Trials Network expands European membership of PET biomarker manufacturers 52568 1SNMs Clinical Trials Network expands European membership of PET biomarker manufacturers 52568 2Noise pollution negatively affects woodland bird communities says CU Boulder study 9334 1Noise pollution negatively affects woodland bird communities says CU Boulder study 9334 2Noise pollution negatively affects woodland bird communities says CU Boulder study 9334 3EPA grant to University of Chicago for research on food allergy triggers 9332 1
...e start of TRILOGY ACS clinical trial to study ... ACS patients, TOKYO and INDIANAPOLIS, June 23 D... Lilly and Company (NYSE: LLY ),said that the U.S...the,review period for the prasugrel new drug appli...vided during the review period. This three,month e...
...fers Tips for Benefits/HR Managers, DALLAS, June ...departments can play an important role in preventi... heart attacks, according to a,leading prevention ...disease prevention., Dr. Boyd Lyles, corporate me...,s not uncommon for heart attacks to strike indivi...
Other Medicine Technology:FDA Extends Review Period for Daiichi Sankyo, Lilly Investigative Antiplatelet Drug, Prasugrel 2FDA Extends Review Period for Daiichi Sankyo, Lilly Investigative Antiplatelet Drug, Prasugrel 3FDA Extends Review Period for Daiichi Sankyo, Lilly Investigative Antiplatelet Drug, Prasugrel 4U.S. Prevention Medicine: Employers Can Help Workers Avoid Heart Attacks 2U.S. Prevention Medicine: Employers Can Help Workers Avoid Heart Attacks 3
(Date:11/25/2009)... KANSASCITY,Mo.,Nov.25/PRNewswire/--TheBartleHallC...gestmedicalcliniconDec.9-10,whenKansasCityhoststhe...ple. ,, "Thisfreecliniceventhasthepotentialtobe...teadofjustoneandbeheldonweekdaysinsteadofoveraweek...eHealthClinicandpresidentoftheNationalAssociationo...
(Date:11/25/2009)... LONGBEACH,Calif.,Nov.25/PRNewswire/--Thanksgiving...eniorsinthegreaterLongBeachareathankstoFaithInActi...endenceatHome(IAH),adivisionofSCANHealthPlan.Formo...sofvolunteerstodeliverwarmThanksgivingmealstosenio...outhLosAngelesandsurroundingcities. ,, "Ourwarm...
(Date:11/25/2009)... BroadPoliticalEndorsements,Business,andPressJoin...wire-USNewswire/--Onceagain,theNationalBipolarFoun...onendorsingtheir"Safe,tilStable"program,whichisnow...orbipolardisorder.Today,theNationalBipolarFoundati...essPriorityMailfromtheLt.GovernorofLouisianaMitchL...
(Date:11/25/2009)...stress increase blood pressure? This simple quest...y years. New Stress-related gene Modulates High B... blood pressure? This simple question has been th...ew research has for the first time established a l... pressure response to stress in mice as well as hu...
(Date:11/25/2009)..., forgetfulness could lead mothers to overlook nee.... 25 (HealthDay News) -- A mother,s depression can...found. , Their six-month study of 262 black mot...mothers had more depressive symptoms had more freq...th fewer depressive symptoms had less frequent ast...
Breaking Medicine News(10 mins):Health News:Kansas City Prepares for Largest Free Health Clinic 2Health News:SCAN Employees and Community Volunteers to Help Deliver One Thousand Thanksgiving Meals to Homebound Seniors 2Health News:First Time-Door is Open for Family Discussion of Bipolar Disorder 2Health News:First Time-Door is Open for Family Discussion of Bipolar Disorder 3Health News:New stress-related gene modulates high blood pressure in mice and men 2Health News:Mom's Depression May Worsen Child's Asthma 2
...the drug isotretinoin zaps acne , The most poten...is retinoic acid (13-cis RA; also known as isotret...sm by which it acts. Insight into the mechanisms b...y, who analyzed skin biopsies from patients with a...
...yzer World,s First UPLC PAT System, Tied Directly ...cy, NEW ORLEANS, March 3 Driven by the vision of...ouldn,t previously be,solved, Waters Corporation (...2008 in New Orleans that expand the,boundaries of ...
...e of Diabetes and Digestive and Kidney Diseases (N...formation to raise awareness about diabetes, diges...ong people not yet diagnosed with these illnesses....s. NIDDK is one of the National Institutes of Heal...
...rk Dental, a Twin Cities area,group dental practic...,community for 40-years, announced today that it h...ts practice from its Boston, Massachusetts-based,a...he doctors of Park Dental and a related group call...
...Raise Awareness, Support Families Affected by,Auti...f America, the nation,s leading grassroots autism ... and fastest-growing franchise of giant indoor,inf... combines family fun with raising awareness and su...
...trating its commitment to growth,and innovation, S...manager,and owner of seniors housing communities n...d chief executive officer. His position includes t...unded the company more than 20,years ago -- will c...
Other Medicine News:Health News:JCI online early table of contents: March 3, 2008 2Health News:JCI online early table of contents: March 3, 2008 3Health News:JCI online early table of contents: March 3, 2008 4Health News:JCI online early table of contents: March 3, 2008 5Health News:JCI online early table of contents: March 3, 2008 6Health News:JCI online early table of contents: March 3, 2008 7Health News:JCI online early table of contents: March 3, 2008 8Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 2Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 3Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 4Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 5Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 6Health News:Park Dental Announces Separation From Its Administrative Service Provider 2Health News:Park Dental Announces Separation From Its Administrative Service Provider 3Health News:Pump It Up and Autism Society of America Launch 'Bounce for Autism' 2Health News:Pump It Up and Autism Society of America Launch 'Bounce for Autism' 3Health News:Senior Lifestyle Corporation Names John Cobb as President and CEO 2
Determine HBsAg - Whole blood (includes chase buffer)
Clearview EASY LH (CE marked)
Clearview Strep A
Inverness Medical Testpack+Plus Strep A with OBC (40 Tests)
Medicine Products: