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Researchers Discover a Common Variation in a Gene Segment that,Increases the Risk for Prostate Cancer

ng of a different variant, marked by SNP rs1447295, is also associated with prostate cancer. The rs1447295 SNP is located nearby on the same arm of chromosome 8. The old and the new susceptibility loci, or gene locations, appear to act independently; a change in one region did not affect the degree of risk conferred by the other. We now have two significant regions in the same general area that convey risk for prostate cancer. This will undoubtedly focus multidisciplinary studies on this stretch of DNA, called 8q24, said Meredith Yeager, Ph.D., lead author on the study.

The rs1447295 location could be responsible for about seven percent of prostate cancer cases in white men of north European descent. Thus, taken together with rs6983267, these two genetic changes could account for as much as one quarter of prostate cancer cases in white men. The increased risk conferred by these loci was observed for all age groups studied.

CGEMS allows us to look systematically across the entire human genome and search for common genetic variations that confer risk for prostate cancer, a very common and very complex disease said Stephen Chanock, M.D., director of NCIs Core Genotyping Facility in the Advanced Technology Center.

Identification of new regions like 8q24 furthers efforts to uncover the genetic basis of prostate cancer, which may eventually lead to more insights into cancer causation in general," added Gilles Thomas, M.D., Ph.D., lead scientist of CGEMS.

An initial genome-wide association study was conducted in 2,329 men from across the United States who are participating in the NCIs Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) that began in 1993. The PLCO analysis compared 1,172 men with prostate cancer to 1,157 who did not have cancer.

CGEMS results were further confirmed by a number of other studies, including the American Cancer Society Cancer Prevention Study II, the Health Professionals Follow-up Study, the
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