Navigation Links
Researchers Discover Method for Identifying How Cancer Evades the,Immune System

key anti-immunity genes, which tumors promote. They studied the expression of these genes in five mouse tumor models for breast cancer, leukemia, colon cancer, lung cancer and renal cell carcinoma. They then compared two of these immune signatures with corresponding human tumors, eight cases of human ductal carcinoma and 11 cases of colorectal cancer.


Remarkably, the researchers found that the immune signatures of each of the human breast cancer cases nearly matched that of mice. In all cases, the researchers saw a suppression of CD83 and CD28, two genes that affect activation of immune cells, and over-production of B7-H4, a gene whose protein product inhibits immune activation. The human colorectal cancers, however, showed variations in their immune signatures, which researchers saw as an indication of the need to understand the signature for each patient’s individual cancer.


“I see it as the beginning stages of personalized medicine, where we develop tactics for treating the unique genetic make-up of a specific tumor,” Epstein said. “It becomes even more necessary when we look at all the immunotherapies that are becoming available or are beginning to emerge from research.”


In time, Epstein believes, it will be possible to study the immune signatures for most, if not all, forms of cancer. In addition, rtPCR technology allows for a relatively inexpensive and rapid analysis on equipment available at most medical centers, researchers said. “For now, we need to better understand the immune signatures for the most common human cancers in order to identify the most important targets for immunotherapy,” Epstein said.


The study was funded by the Philip Morris External Research program by Philip Morris USA, Inc., Philip Morris International and by support provided by Cancer Therapeutics Laboratories, Inc.


# # #

The mission of the American Association for Ca
'"/>




Page: 1 2 3

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Researchers Discover Gene For Rare Skin Disorder
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
6. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
7. Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report
8. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
9. Researchers Urge Caution in Using ESAs for Cancer-Related Anemia
10. Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
11. Abbott Researchers Focus on New Cutting-Edge Approaches in the Fight Against Cancer
Post Your Comments:
(Date:4/17/2015)... , April 17, 2015 ... Market Research Report on Global and China Lysine ... is a professional and the deep research report ... introduces Lysine basic information including definition, classification specifications, ... as US, Europe , ...
(Date:4/17/2015)... 17, 2015 Inivata, a ... that their presence at the 2015 American Association for Cancer ... co-founder Nitzan Rosenfeld and a poster presentation. ... th - 22 nd . The presentation, ... , forms part of a session on ...
(Date:4/17/2015)... CVS Health Corporation (NYSE: CVS ) ... 1, 2015, at 8:30 a.m. (EDT) with analysts and ... An audio webcast of the conference call will ... the CVS Health website for all interested parties. To ... will be archived and available on the web site ...
Breaking Medicine Technology:Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5Inivata Co-founder Nitzan Rosenfeld to Present at AACR Annual Meeting 2
... , DES MOINES, Iowa, Oct. 12 Briggs, a ... reduce operating costs in the home care market, today ... mandated by the Centers for Medicare & Medicaid Services ... proprietary documentation for all OASIS assessment forms as well ...
... 12 The University of Kansas Hospital has deployed ... provide physicians, nurses, and pharmacy staff in its neonatal ... and reference information. , The University of ... specializes in heart disease, cancer treatment and prevention, neurology, ...
Cached Medicine Technology:Regulatory Leader in OASIS Documentation Introduces OASIS-C Products 2University of Kansas Hospital Deploys NeoFax from Thomson Reuters for Electronic Neonatal Drug Dosing to Support Medication Safety 2University of Kansas Hospital Deploys NeoFax from Thomson Reuters for Electronic Neonatal Drug Dosing to Support Medication Safety 3
(Date:4/17/2015)... Riviera Magazine has featured board ... the Gallery of Cosmetic Surgery in Newport Beach, California ... The publication focused on his expertise in the lower ... eyelid surgery, laser resurfacing and rhinoplasty. , Dr. Sadati’s ... resulted in thousands of satisfied patients across the globe. ...
(Date:4/17/2015)... 17, 2015 From the day Dr. Todd ... Texas non-profit organization has empowered young people to create meaningful ... bring fresh water and the Gospel to all of ... Between March 17 and 27, students, faculty and staff raised ... with fresh water and the Good News of Jesus. ...
(Date:4/17/2015)... 17, 2015 Enthusiasts of gourmet cuisine and ... April 25, 2015. The event will be held in the ... (201 Monroe Ave NW, Grand Rapids, MI 49503) and will ... Michigan area. Patrons are encouraged to savor the food and ... , This year’s event will feature seven chefs, including:, ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Testosterone ... this class of prescription medications increases the likelihood ... stroke or other life-threatening cardiovascular event continue to ... District Court, Northern District of Illinois. According to ... Judicial Panel on Multidistrict Litigation (JPML) on April ...
(Date:4/17/2015)... Francisco, CA (PRWEB) April 17, 2015 The American ... House event and Free Application Day on April 29. The event ... ACTCM Pioneer Square, located at 555 DeHaro St. in San Francisco, ... 11 a.m. – Check in at the DeHaro campus (room F), ... – Tour of campus, Noon – Light lunch with current students, ...
Breaking Medicine News(10 mins):Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... By Serena Gordon HealthDay Reporter , TUESDAY, Oct. ... an advance directive may raise the odds that you,ll receive ... care, a new study indicates. An advance directive, sometimes ... your wishes for the type of care you would like ...
... By Randy Dotinga HealthDay Reporter , TUESDAY, Oct. 4 ... develop breast cancer tend to have more advanced cases than women ... statistics are adjusted for factors such as age, men with breast ... are. The findings shed light on a rare disease in ...
... News) --, People may be learning while they sleep, dramatically ... Although the effects on memory vary greatly and ... findings reinforce the need for a good night,s sleep -- ... the U.S. National Sleep Foundation. "We speculate that we ...
... , TUESDAY, Oct. 4 (HealthDay News) -- ... a recurrence of the disease and improve their overall ... The group pointed out that physical activity has many ... reduced fatigue and improved mood. To help mark ...
... Salamon HealthDay Reporter , TUESDAY, Oct. 4 (HealthDay ... of nature versus nurture, it appears that kids unlucky enough ... sunnier outlooks when they,re parented in a warm, positive manner. ... through 15 with a gene variation predisposing them to lower ...
... at Virginia G. Piper Cancer Center Clinical Trials at ... participate in a clinical trial to determine the safety, ... combination consisting of a standard drug called gemcitabine and ... cancer. The results of this study, ...
Cached Medicine News:Health News:Advance Directives Might Curb Cost of End-of-Life Care 2Health News:Advance Directives Might Curb Cost of End-of-Life Care 3Health News:Breast Cancer Appears Less Deadly for Men Than Women 2Health News:Exercise Tips for Breast Cancer Survivors 2Health News:Happy Kids a Product of Genes, Parenting, Study Finds 2Health News:Happy Kids a Product of Genes, Parenting, Study Finds 3Health News:TGen/Virginia G. Piper Cancer Center publish results of new drug for pancreatic cancer patients 2
... is an endoscopic urethral implant for ... Upon implantation, the Tegress™ Implant solution ... in a Dimethyl Sulfoxide (DMSO) carrier ... reinforces the integrity of the urethras ...
... (VZ) test system is intended ... detection of VZ IgG antibody ... indirect fluorescent antibody (IFA) technique. ... confirm a recent infection or ...
... Captia™ Varicella-Zoster Virus (VZV) IgM ... intended for the detection of ... in human serum as an ... primary infection or reactivation. For ...
... Biotech Captia™ Varicella-Zoster Virus (VZV) IgG Enzyme-linked ... detection and quantitative determination of IgG antibody ... specimens may be used for the determination ... convalescent, may be used to demonstrate seroconversion ...
Medicine Products: