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Research on New Treatment for Neglected Disease Published in The,New England Journal of Medicine

SAN FRANCISCO & NEW DELHI, India--(BUSINESS WIRE)--Jun 21, 2007 - The Institute for OneWorld Health, a US-based non-profit pharmaceutical company, today announced that Phase 3 research related to its first approved drug product, Paromomycin IM Injection (Paromomycin), was published in the current issue of The New England Journal of Medicine (NEJM). This clinical trial shows that the medicine paromomycin is safe, effective, and well suited to curing visceral leishmaniasis (VL), the world's second most deadly parasitic disease after malaria.

The Institute for OneWorld Health, working closely with the Indian Council for Medical Research (ICMR) sponsored the clinical trial in collaboration with the Special Programme for Research and Training in Tropical Diseases (TDR), a Geneva-based international organization sponsored by UNICEF, UNDP, the World Bank and the World Health Organization. The clinical trial was established with funding from the Bill & Melinda Gates Foundation.

Gland Pharma Limited, the Hyderabad, India-based drug manufacturer, working with OneWorld Health and other collaborators, received regulatory approval from the Drug-Controller General - India (DCGI) for Paromomycin IM Injection as a treatment for VL on August 31, 2006. Gland Pharma has agreed to act as the global manufacturer of Paromomycin to ensure access to all those that need it, and at a markedly reduced cost -- currently, approximately $10 USD per 21-day course of therapy.

"The results of this study underscore the potential of Paromomycin to treat VL -- and save lives -- at very low cost and in safe and practical ways," said Dr. Ahvie Herskowitz, co-founder and chief medical officer of the Institute for OneWorld Health. "This research is essential to increasing access to new therapies for this neglected disease, also known as kala-azar and black fever."

With approximately 500,000 new cases occurring annually wo
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