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Research Supported by Samuel Waxman Cancer Research Foundation,Discovers Mode of Action of Arsenic-Based Drugs in Destroying,Cancer Cells

ard treatment for APL. Recent information indicates that the combination of the vitamin A derivative retinoic acid, arsenic and chemotherapy may cure over 90% of APL patients, which may result in extending the lives of an estimated 50,000 people a year.

About SWCRF

Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies with minimal toxicity, such as differentiation therapy. Two drugs developed through Foundation-supported research, and now used worldwide, have proven the effectiveness of non-toxic differentiation in the treatment of acute promyelocytic leukemia (APL).

Since its inception, SWCRF has trained and supported more than 170 scientists with research grants exceeding $60 million. Based in New York City at The Mount Sinai Medical Center, the Foundation funds highly collaborative basic, translational and clinical research groups throughout the United States, Canada, China, Europe and Israel. SWCRF grant applicants are established investigators who agree to collaborate with other SWCRF investigators on all research projects funded by the Foundation.

Functioning as an "Institute Without Walls" the Foundation currently enables the collaboration of accomplished scientists in 28 different world-renown cancer research centers around the world. SWCRF hosts international conferences that bring together differentiation therapy investigators in a major forum to share their findings with the scientific community. Foundation-supported projects are reviewed and evaluated annually by an independent external committee of eminent scientists.

The Foundation derives most of its support from individual contributions. For the third consecutive year, Charity Navigator has awarded SWCRF its coveted four-star rating, indicating that the Foundation operates in the most fiscal
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