Navigation Links
Research Supported by Samuel Waxman Cancer Research Foundation,Discovers Mode of Action of Arsenic-Based Drugs in Destroying,Cancer Cells

NEW YORK--(BUSINESS WIRE)--Apr 16, 2007 - Arsenic, a naturally occurring element, has been used in therapeutic compounds for over 2,000 years, and even now remains a venerable constituent of the traditional Chinese pharmacopeia.

Today, due in measure to the efforts of investigators supported by grants from the Samuel Waxman Cancer Research Foundation's (SWCRF) "Institute Without Walls," an arsenic derivative is being utilized in therapy for the treatment of certain types of acute leukemia.

In an important new development that holds promise for wider use of arsenic for treatment of other forms of cancer, the January 3, 2007 issue of the Journal of the National Cancer Institute published the results of research describing a new mode of action of arsenite (a form of the metal arsenic) in the treatment of acute promyelocytic leukemia (APL).

The research, conducted by Dr. Ethan Dmitrovsky, and his colleagues at Dartmouth Medical School, determined that arsenite selectively destroys APL cells. It was observed that arsenite causes a form of cell "suicide" in which digestive enzymes usually sequestered within the cancer cell are released into the cell at large.

Dr. Samuel Waxman, Founder and Scientific Director of SWCRF, notes "This discovery of a new mode of action of arsenic-based therapies establishes a new pathway that can lead to broader use of arsenic in developing therapies for treating other forms of cancer. It most certainly presents a new platform of knowledge that can stimulate new ideas that may ultimately increase the cure rate of APL to near 100%."

SWCRF provided grants supporting the research program led by Dr. Dmitrovsky, who is the Andrew G. Wallace Professor of Medicine and Pharmacology and Chairman, Pharmacology and Toxicology of Dartmouth Medical School, and also serves as Associate Scientific Director of SWCRF.

Arsenic and its derivatives are now part of the stand ard treatment for APL. Recent information indicates that the combination of the vitamin A derivative retinoic acid, arsenic and chemotherapy may cure over 90% of APL patients, which may result in extending the lives of an estimated 50,000 people a year.

About SWCRF

Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies with minimal toxicity, such as differentiation therapy. Two drugs developed through Foundation-supported research, and now used worldwide, have proven the effectiveness of non-toxic differentiation in the treatment of acute promyelocytic leukemia (APL).

Since its inception, SWCRF has trained and supported more than 170 scientists with research grants exceeding $60 million. Based in New York City at The Mount Sinai Medical Center, the Foundation funds highly collaborative basic, translational and clinical research groups throughout the United States, Canada, China, Europe and Israel. SWCRF grant applicants are established investigators who agree to collaborate with other SWCRF investigators on all research projects funded by the Foundation.

Functioning as an "Institute Without Walls" the Foundation currently enables the collaboration of accomplished scientists in 28 different world-renown cancer research centers around the world. SWCRF hosts international conferences that bring together differentiation therapy investigators in a major forum to share their findings with the scientific community. Foundation-supported projects are reviewed and evaluated annually by an independent external committee of eminent scientists.

The Foundation derives most of its support from individual contributions. For the third consecutive year, Charity Navigator has awarded SWCRF its coveted four-star rating, indicating that the Foundation operates in the most fiscal ly responsible way possible to utilize its resources to attain its goal of a world without cancer.

For more information, visit www.waxmancancer.org.

Contact

Broadford & Maloney Inc.
Martin Maloney, 203-661-2900
m.maloney@bmcorp.com
or
Samuel Waxman Cancer Research Institute
Merle Duskin Kailas, 212-241-1760
mkailas@waxmancancer.org


'"/>




Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Suven Life Sciences Presenting Pre-clinical data of their NCE’s SUVN-502 and SUVN-507at International Brain Research Organization (IBRO) 2007 World Congress of Neuroscience
4. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
5. Researchers Discover Method for Identifying How Cancer Evades the Immune System
6. Infertile Voice Supports Stem Cell Research: RESOLVE Calls for Patient Options in Using Frozen Embryos
7. Fact Sheet: Advancing Stem Cell Research While Respecting Moral Boundaries
8. President Bush Ignores Americas Plea for Support of Stem Cell Research
9. Researchers Discover Gene For Rare Skin Disorder
10. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
11. Research on New Treatment for Neglected Disease Published in The New England Journal of Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... 2016  Avista Pharma Solutions ("Avista Pharma") announced today ... Financial Officer (CFO). Mr. Setzer is a finance and ... various roles within growing technology and life science companies. ... Executive Director of Finance at INC Research, a publicly ... . Previously, Mr. Setzer served as CFO of ...
(Date:2/8/2016)... 2016 Vestagen Technical Textiles, Inc., a medical ... healthcare and other demanding applications, today announced it has ... replaces Dale Pfost , PhD, who was serving ... also joining Vestagen,s Board of Directors. ® ... barrier technologies that combines fluid repellent, antimicrobial and breathability ...
(Date:2/8/2016)... , Feb. 8, 2016  Astellas Pharma Inc. President ... the promotion of James Robinson as president, Americas ... operations in North and South America , ... Pharma US, representing the commercial organization in the ... 2013. Masao Yoshida , who is retiring ...
Breaking Medicine Technology:
(Date:2/8/2016)... ... 2016 , ... Brenton Engineering , powered by Pro ... wrapped products at WestPack 2015, February 9-11, in Anaheim, California. This new solution ... or fully-automatic case packing with a small footprint, rugged, highly flexible, and cost-effective ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... community enrichment program serving the greater Venice, FL area, has initiated a fundraiser ... in a car accident just four days after Christmas. To support this beautiful ...
(Date:2/8/2016)... ... February 08, 2016 , ... FileHold's document management software has ... a cloud hosted environment for FileHold software that is pay per user subscription-based ... applications using the FileHold web services API. DocuSyst also advises clients on fully ...
(Date:2/8/2016)... ... February 08, 2016 , ... Joshua ... on how healthcare companies can use newly released government data on populations and ... population and intervene and capture the value they create to succeed in new ...
(Date:2/7/2016)... ... February 07, 2016 , ... Women's Excellence staff, in all four ... National Wear Red Day is the first Friday each February and a day ... cause 1 in 3 deaths among women each year – more than all cancers ...
Breaking Medicine News(10 mins):