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Research Results on FluMist Presented at National Association of,Pediatric Nurse Practitioners Conference

and nursing, medical and pharmacy schools. Licensed health professionals were trained to administer FluMist. Over the course of three days, more than 5,000 schoolchildren and nearly 450 staff members were vaccinated.

Cooperation between government, academic, and corporate partners enabled quick and effective design and implementation of a large-scale influenza vaccination campaign using predominantly local medical and lay volunteers. The outcome of this program is being used to create a curriculum to teach undergraduate and advanced practice students the skills needed to effectively participate in a rapid mass-immunization program.

Study Results Demonstrated 55 Percent Fewer Cases of Flu in Young Children Vaccinated with FluMist Compared with the Flu Shot

This Phase 3 study evaluated the incidence of influenza illness among young children vaccinated with FluMist compared to those vaccinated with the flu shot. The study of 8,475 children, between 6 months and 59 months of age, was conducted at 249 sites across the United States, Europe, Asia and the Middle East by MedImmune during the 2004-2005 influenza season. Children immunized with FluMist experienced 55 percent fewer cases of influenza compared to children who received the flu shot (153 vs. 338 cases, P<0.001). In the study, FluMist also demonstrated protection against influenza strains that were both matched and mismatched to the vaccine. The research was published in The New England Journal of Medicine on February 15, 2007.

Generally, both vaccines were well-tolerated. In children 6 months to 11 months of age, FluMist was associated with statistically significantly more hospitalizations for any cause. A non-significant trend toward more hospitalizations in the FluMist group was seen in children 12 months to 59 months of age with a past history of wheezing. These observations require additional study. Until further information is available, MedImmune is presently not seeking an indic
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